Results 81 to 90 of about 46,185 (207)
Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta
Scientific Reports, 2017 The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is involved in the synthesis of active steroid hormones. Two human 3β-HSD isoforms are expressed in a tissue-specific pattern.
Tsai-Chun Lai +5 more
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The GATA-3 gene is expressed during human kidney embryogenesis
Kidney International, 1995 GATA-3 is a transcription factor involved in the differentiation of T lymphocytes and additionally expressed in several chicken and mouse embryonic tissues. Using in situ hybridization, we found that the human GATA-3 gene is selectively expressed in the developing kidney. GATA-3 mRNA is first detected in the Wolffian duct from the time of its emergence
Labastie, Marie-Claude +3 more
openaire +2 more sources
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】 构建GATA-3基因正义?反义重组质粒,为进一步研究GATA-3在T细胞发育分化中的作用提供基础?【方法】 采用PCR技术扩增GATA-3基因,通过酶切?连接?转化等分子生物学技术,将该全长基因亚克隆至表达载体pCDNA3,构建质粒后转染大肠杆菌,并在大肠杆菌中扩增?同时用脂质体法感染大鼠脑细胞?【结果】 从大鼠脑细胞中成功地克隆出全长1335 bp的GATA-3基因,并经序列分析筛选证实GATA-3基因以正向?反向重组转染入载体,且在大肠杆菌中得到扩增,同时用RT ...
杨培增, 黄祥坤, 纪淑兴
doaj
A MULTI-OMICS REVIEW OF GATA-3
Journal of Student ResearchBreast cancer is a prevalent mutation-caused disease that affects millions of people worldwide. One such gene that is related to causing the cancer is GATA3. This gene is a regulator of t-cell development and is also involved with causing luminal breast cancer when altered.
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Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions
Allergy, EarlyView.Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira +13 more
wiley +1 more source
Basic and Clinical Neuroscience, 2018 Introduction: Multiple Sclerosis (MS) is an inflammatory disorder caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. The Th1 and Th2 cell differentiation are regulated by specific transcription factors, especially T-bet and ...
Zahra Etesam +6 more
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BJU International, Volume 135, Issue 4, Page 648-656, April 2025.Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong +14 more
wiley +1 more source
The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics
Clinical Genetics, EarlyView.The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree +18 more
wiley +1 more source
Diagnostic utility of GATA3 immunohistochemical expression in urothelial carcinoma
Indian Journal of Pathology and Microbiology, 2019 Aims: This study aims to explore the utility of GATA binding protein 3, a zinc finger transcription factor, expression in genitourinary carcinoma, especially urothelial carcinoma.
Harshita Agarwal +7 more
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