Results 81 to 90 of about 18,362,222 (202)
Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions
Allergy, EarlyView.Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira +13 more
wiley +1 more source
OncoImmunology, 2019 Intravesical Bacille Calmette-Guérin (BCG) remains the most effective treatment for high-risk non-muscle-invasive bladder cancer (NMIBC), unfortunately there is no validated biomarker to predict clinical outcome.
Roberto Martínez +12 more
doaj +1 more source
GATA-3 suppresses IFN-γ promoter activity independently of binding to cis-regulatory elements [PDF]
, 2004 The regulatory mechanism by which GATA-3 suppresses IFN-γ gene expression was investigated. A reduction of GATA-3 using RNA interference technology enhanced, whereas overexpression of GATA-3 suppressed IFN-γ mRNA expression.
Kazunari Taira +15 more
core +1 more source
Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination
Allergy, EarlyView.We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera +14 more
wiley +1 more source
, 2013 Both T-bet and GATA-3, Th1/Th2 lineage-specific transcription factors, play important roles in the development of T cells and Th1/Th2 differentiation. In this study, T-bet and GATA-3 genes were cloned from grass carp (Ctenopharyngodon idellus).
Guo, Qionglin +5 more
core +1 more source
Spindle Cell Lesions of the Breast: A 12‐Year Experience
ANZ Journal of Surgery, EarlyView.This 12‐year, single‐centre study examined 30 core‐biopsy‐diagnosed breast spindle cell lesions (BrSCL), classified as atypical (ASCL, n = 10) or bland (BSCL, n = 20). Following excision, 80% of ASCLs proved malignant, comprising sarcoma, malignant phyllodes tumour and metaplastic carcinoma.
Shalvin Jassal +4 more
wiley +1 more source
BJU International, Volume 135, Issue 4, Page 648-656, April 2025.Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong +14 more
wiley +1 more source
Recurrence of Breast Cancer With Scalp Metastasis
The Kaohsiung Journal of Medical Sciences, EarlyView.
Yi‐Nan Zhu +3 more
wiley +1 more source
Cancer Science, EarlyView.ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba +21 more
wiley +1 more source
针刺研究, 2012 Objective To observe the effect of autoblood acupoint-injection(ABAI) on expression levels of pulmonary transacting T-cell-specific transcription factor GATA 3(involving Th 2 cytokine expression),Th 1-specific T-box transcription factor T-box expressed ...
MO Lü +6 more
doaj +2 more sources