Results 101 to 110 of about 46,185 (207)

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

T-bet and GATA-3 Gene Expression in Children with Allergic Asthma and Healthy Controls

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Allergic asthma is a chronic inflammatory disorder with increased inflammation and bronchial over react to stimulants. Th1 and Th2 cells are the main cells involved in the pathophysiology of asthma.
Mostafa Kardan, Javad Ghaffari, Reza Valadan, Alireza Rafiei, Mostafa Soltani, Meysam Aghajani, Marziyeh Mohammadi   +6 more
doaj  

Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression. [PDF]

J Immunol, 2022
Thompson PK, Chen ELY, de Pooter RF, Frelin C, Vogel WK, Lee CR, Venables T, Shah DK, Iscove NN, Leid M, Anderson MK, Zúñiga-Pflücker JC.   +11 more
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity. [PDF]

Int J Mol Sci, 2022
Al-Jaber H, Mohamed NA, Govindharajan VK, Taha S, John J, Halim S, Alser M, Al-Muraikhy S, Anwardeen NR, Agouni A, Elhissi A, Al-Naemi HA, Al-Mansoori L, Elrayess MA.   +13 more
europepmc   +1 more source

A quantitative dissection of the DNA‐binding properties of pathogenic GATA1 mutants

The FEBS Journal, EarlyView.
Transcription factor activity is influenced by cell context, accessibility of target sequences, and co‐factor recruitment. Quantitatively characterizing the consequences of individual mutations in the transcription factors or their target sequences remains technically challenging. Zambo et al. use mutant GATA1‐ATP2B4 binding to illustrate an innovation
Kaoru Takasaki
wiley   +1 more source

GATA-3 in Atlantic salmon (Salmo salar): Tissue distribution and its regulation of IL-4/13a promoter. [PDF]

Front Cell Infect Microbiol, 2022
Chi H, Meng X, Dalmo RA.
europepmc   +1 more source

NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury

Journal of Diabetes Investigation, EarlyView.
In diabetic kidney disease (DKD), the acetyltransferase NAA10 mediates the acetylation of CREBRF, promoting its recognition and binding by the E3 ubiquitin ligase BTRC, thereby enhancing the ubiquitination level of CREBRF and accelerating its degradation.
Sitian Fang, Jing Ning, Jinjing Huang, Yanxia Chen   +3 more
wiley   +1 more source

Comparison of GATA-3, Mammaglobin and GCDFP-15 Expression in Primary, Metastatic and Triple Negative Breast Carcinomas: An Indian Scenario. [PDF]

Asian Pac J Cancer Prev, 2023
Rao M, Khade S, Chaudhary R, Singh P, Yadav G, Elhence P, Nalwa A, Sharma R, Goel AD.   +8 more
europepmc   +1 more source

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, EarlyView.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source