Results 21 to 30 of about 46,185 (207)

GATA-3 Function in Innate and Adaptive Immunity [PDF]

Immunity, 2014
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression. More recently, GATA-3 was shown to contribute to type 2 immunity through regulation of group 2 innate lymphoid cell (ILC2) development and ...
Tindemans, Irma, Serafini, Nicolas, Di Santo, James P, Hendriks, Rudi W   +3 more
openaire   +3 more sources

Can GATA3 Immunocytochemistry be Utilized as a Reliable Diagnostic Marker for Metastatic Breast Carcinoma in Cytological Materials? A Comparative Study with Mammaglobin and GCDFP-15 Expression [PDF]

Türk Patoloji Dergisi, 2018
Objective: Cytomorphologic differentiation of metastatic breast carcinoma from non breast metastases in cytological materials can be difficult. Current breast immunocytochemical markers have low sensitivities.
Nesreen H. HAFEZ, HebatAllah M. SHAABAN
doaj   +1 more source

GATA‐binding protein 3 and gross cystic disease fluid protein 15 as a potential diagnostic marker for extramammary Paget's disease

Journal of Cutaneous Immunology and Allergy, 2021
Objectives The aim of this study was to evaluate the expression of GCDFP15 and GATA‐binding protein 3 (GATA‐3) in extramammary Paget's disease (EMPD) skin and serum samples and to assess their availability as tumor markers for the diagnosis and ...
Soichiro Kado, Koji Kamiya, Meijuan Jin, Miho Kimura, Md Razib Hossain, Takeo Maekawa, Mayumi Komine, Mamitaro Ohtsuki   +7 more
doaj   +1 more source

GATA-3 and the regulation of the mammary luminal cell fate [PDF]

Current Opinion in Cell Biology, 2008
The GATA family of transcription factors plays essential roles in the specification and maintenance of differentiated cell types. GATA-3 was identified in a microarray screen of the mouse mammary gland as the most highly expressed transcription factor in the mammary epithelium and is expressed exclusively in the luminal epithelial cell population ...
Hosein, Kouros-Mehr, Jung-whan, Kim, Seth K, Bechis, Zena, Werb   +3 more
openaire   +2 more sources

Transcription factor GATA‐3 is essential for lens development [PDF]

Developmental Dynamics, 2009
AbstractDuring vertebrate lens development, the anterior, ectoderm‐derived lens vesicle cells differentiate into a monolayer of epithelial cells that retain proliferative potential. Subsequently, they exit the cell cycle and give rise to posterior lens fiber cells that form the lens body.
Maeda, Atsuko, Moriguchi, Takashi, Hamada, Michito, Kusakabe, Manabu, Fujioka, Yuki, Nakano, Takako, Yoh, Keigyou, Lim, Kim-Chew, Engel, James Douglas, Takahashi, Satoru   +9 more
openaire   +3 more sources

Embryonic expression and cloning of the murine GATA-3 gene [PDF]

Development, 1994
ABSTRACT We describe the embryonic expression pattern as well as the cloning and initial transcriptional regulatory analysis of the murine (m) GATA-3 gene. In situ hybridization shows that mGATA-3 mRNA accumulation is temporally and spatially regulated during early development: although found most abundantly in the placenta prior to 10 ...
K M, George, M W, Leonard, M E, Roth, K H, Lieuw, D, Kioussis, F, Grosveld, J D, Engel   +6 more
openaire   +2 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Aberrant Gata-3 Expression in Human Pancreatic Cancer [PDF]

Journal of Histochemistry & Cytochemistry, 2006
Gata-3 has been shown to specifically alter its expression patterns in different types of cancers. Recent evidence suggests that an interference of Gata-3 exists in the TGF-β signaling pathway. To determine the role of Gata-3 in pancreatic cancer, pancreatic cancer samples were analyzed in comparison to normal pancreatic tissues.
Antanas, Gulbinas, Pascal O, Berberat, Zilvinas, Dambrauskas, Thomas, Giese, Nathalia, Giese, Frank, Autschbach, Joerg, Kleeff, Stefan, Meuer, Markus W, Büchler, Helmut, Friess   +9 more
openaire   +2 more sources

Embryonic expression of the human GATA-3 gene

Mechanisms of Development, 1999
The spatial and temporal analysis of GATA-3 expression pattern in the human embryo revealed its expression in new anatomical sites. These include the endoderm of the primitive foregut, pharynx and allantois, the branchial arches and the mesenchymal cells surrounding the stomach and dorsal aorta.
Debacker, Cécile, Catala, Martin, Labastie, Marie-Claude   +2 more
openaire   +2 more sources

GATA-3 EXPRESSION IN PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH BRONCHIAL ASTHMA

Медицинская иммунология, 2014
The aim of the study is to establish the features of expression of GATA-3 in peripheral lymphocytes from bronchial asthma patients (BA). Material and methods.
V. N. Mineev, L. N. Sorokina, M. A. Nyoma, V. I. Trofimov   +3 more
doaj   +1 more source