Transactivation of human osteoprotegerin promoter by GATA-3. [PDF]
Sci Rep, 2015 AbstractOsteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations in OPG are involved in a variety of human diseases. We have shown that cochlear spiral ganglion cells secrete OPG at high levels and lack of OPG causes sensorineural hearing loss in addition to the previously described conductive hearing loss.
Kao SY, Stankovic KM.
europepmc +8 more sources
GATA-3 Stimulates Proliferation of Endometriotic Cells [PDF]
Ginekologia Polska, 2019 This study aimed to investigate whether there was a correlation between the expression of GATA binding protein 3 (GATA-3) and the proliferation of endometrium cells from women with endometriosis.Endometrial tissue was collected from 20 women with endometriosis (experimental group) and 10 women without endometriosis (control group).
Peng, Chen, Fang, Ren, Dan-Bo, Wang
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GATA-3 Function in Innate and Adaptive Immunity [PDF]
Immunity, 2014 The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression. More recently, GATA-3 was shown to contribute to type 2 immunity through regulation of group 2 innate lymphoid cell (ILC2) development and ...
Tindemans, Irma +3 more
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Caveolin-1, GATA-3, and Ki67 expressions and their correlation with pathological findings in canine bladder urothelial carcinoma [PDF]
Frontiers in Veterinary Science, 2022 The bladder urothelial carcinoma (UC) represents ~2% of malignant neoplasms in dogs and is a therapeutic challenge in veterinary medicine. Although it is considered the most common bladder cancer in dogs, few previous studies have investigated different ...
Verônica Mollica Govoni +9 more
doaj +2 more sources
Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells [PDF]
Mediators of Inflammation, 2016 Decreased Th1/Th2 ratio is one of the major characteristics of immunosuppression in sepsis. Both membrane adhesive protein Annexin-A1 (ANXA1) and transcription factor GATA-3 have been reported to play important roles in T cell differentiation.
Peng Huang +3 more
doaj +2 more sources
Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice [PDF]
Molecules, 2021 Cicadae Periostracum (CP), derived from the slough of Cryptotympana pustulata, has been used as traditional medicine in Korea and China because of its diaphoretic, antipyretic, anti-inflammatory, antioxidant, and antianaphylactic activities.
Seung-Hyung Kim +5 more
doaj +2 more sources
Double cocktail immunostains with high molecular weight cytokeratin and GATA-3: useful stain to discriminate in situ involvement of prostatic ducts or acini from stromal invasion by urothelial carcinoma in the prostate [PDF]
Journal of Pathology and Translational Medicine, 2020 Background Distinguishing prostatic stromal invasion (PSI) by urothelial carcinoma (UC) from in situ UC involving prostatic ducts or acini with no stromal invasion (in situ involvement) may be challenging on hematoxylin and eosin stained sections ...
Junghye Lee +5 more
doaj +2 more sources
Down-regulated GATA-1 up-regulates interferon regulatory factor 3 in lung adenocarcinoma
Scientific Reports, 2017 Interferon regulatory factor 3 (IRF-3) is widely known for its prompt response against viral infection by activating the interferon system. We previously reported that E2F1, Sp1 and Sp3 regulated transcriptional activity of IRF-3.
Lu-Lu Wang +9 more
doaj +2 more sources
Critical Roles for Transcription Factor GATA-3 in Thymocyte Development [PDF]
Immunity, 2003 The transcription factor GATA-3 is expressed at every stage of thymic development, but its role in thymocyte differentiation is unknown. The fact that RAG chimeric animals lacking GATA-3 cannot generate early thymocytes from common lymphoid progenitors has thus far precluded investigation of the function of GATA-3 in the thymus.
Pai, Sung-Yun +5 more
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Partial Rescue of GATA-3 by Yeast Artificial Chromosome Transgenes [PDF]
Developmental Biology, 1998 GATA-3 is essential for murine embryonic development, but elucidating the genetic controls over the complex temporal and tissue-specific transcriptional regulatory pattern of this transcription factor gene has been problematic. Here we report the isolation and characterization of two yeast artificial chromosomes (YACs) bearing the murine GATA-3 gene ...
Lakshmanan, G +3 more
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