Results 21 to 30 of about 11,020,373 (290)
Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18. [PDF]
J Immunol, 2023 CD4 tissue-resident memory T cells (TRMs) allow robust protection of barrier surfaces against pathogens. We investigated the role of T-bet in the formation of liver CD4 TRMs using mouse models.
Depew CE +5 more
europepmc +2 more sources
Temporal Dissection of T-bet Functions [PDF]
The Journal of Immunology, 2007 Abstract T-bet is a transcription factor of the T-box family that regulates the expression of numerous immune system-associated genes. T-bet directs the acquisition of the Th1-associated genetic program in differentiating CD4+ lymphocytes.
Jennifer L, Matsuda +3 more
openaire +2 more sources
Asthma: T-bet — A Master Controller? [PDF]
Current Biology, 2002 The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma.
Robinson, Douglas S, Lloyd, Clare M
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Anti-proliferative Activity of T-bet [PDF]
Immune Network, 2015 T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4(+) precursor cells. Since T-bet directly binds to the promoter of the IFN-γ gene and activates its transcription, T-bet deficiency impairs IFN-γ production in Th1 cells.
Oh, Yeon Ji +3 more
openaire +2 more sources
A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity
Cell Reports, 2023 Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions.
Masaaki Okamoto +7 more
doaj +1 more source
T-bet−/− RAG2−/− ulcerative colitis: The role of T-bet as a peacekeeper of host–commensal relationships [PDF]
Cytokine, 2009 Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig. 1].
Wendy S, Garrett, Laurie H, Glimcher
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T‐bet as a key regulator of mucosal immunity [PDF]
Immunology, 2016 SummaryInitially understood to be a key regulator of interferon‐γ‐producing helper T cells, our knowledge of T‐bet's functional roles has expanded to encompass a growing range of cellular lineages. In addition to regulating other interferon‐γ‐producing adaptive immune cells, it is now clear that T‐bet plays a fundamental role in the regulation of ...
Mohamed, Rami, Lord, Graham M.
openaire +4 more sources
Expression Regulation and Function of T-Bet in NK Cells. [PDF]
Front Immunol, 2021 Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-γ, IL-12, IL-15 and IL-21 through the respective cytokine receptors ...
Huang C, Bi J.
europepmc +5 more sources
Cell Metabolism, 2013 Although increasing adiposity is usually associated with adipose tissue infiltration by inflammatory cells and systemic insulin resistance, Stolarczyk et al. (2013) report in this issue that mice deficient in the T-box transcription factor, T-bet, display a dissociated phenotype with enhanced perigonadal adipose but enhanced insulin sensitivity.
openaire +2 more sources
The evolving role of T-bet in resistance to infection [PDF]
Nature Reviews Immunology, 2019 The identification of T-bet as a key transcription factor associated with the development of IFNγ-producing CD4+ T cells predicted a crucial role for T-bet in cell-mediated immunity and in resistance to many intracellular infections. This idea was reinforced by initial reports showing that T-bet-deficient mice were more susceptible to pathogens that ...
Gretchen Harms, Pritchard +2 more
openaire +2 more sources