Results 21 to 30 of about 10,355,186 (284)
Scientific Reports, 2021 T-bet is a key transcription factor for the T helper 1 lineage and its expression level is negatively correlated to inflammation in patients with rheumatoid arthritis (RA).
Masaru Shimizu +8 more
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Immunity, 2017 In this issue of Immunity, Iwata et al. (2017) report that the transcription factor T-bet acts as a selective repressor of the type I interferon (IFN) transcriptional program in response to IFN-γ signaling.
Vanja, Lazarevic +2 more
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Zdorovʹe Rebenka, 2023 Background. Breast milk (BM) is an optimal nutritional product for newborns and a source of exogenous microRNAs (miR). MiR-148a is one of the most highly expressed miR of BM. Currently, there is a lack of data on the miR-148a effect on the development of
O.E. Abaturov, A.O. Tovarnytska
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Temporal Dissection of T-bet Functions [PDF]
The Journal of Immunology, 2007 Abstract T-bet is a transcription factor of the T-box family that regulates the expression of numerous immune system-associated genes. T-bet directs the acquisition of the Th1-associated genetic program in differentiating CD4+ lymphocytes.
Jennifer L, Matsuda +3 more
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Asthma: T-bet — A Master Controller? [PDF]
Current Biology, 2002 The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma.
Robinson, Douglas S, Lloyd, Clare M
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Anti-proliferative Activity of T-bet [PDF]
Immune Network, 2015 T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4(+) precursor cells. Since T-bet directly binds to the promoter of the IFN-γ gene and activates its transcription, T-bet deficiency impairs IFN-γ production in Th1 cells.
Oh, Yeon Ji +3 more
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A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity
Cell Reports, 2023 Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions.
Masaaki Okamoto +7 more
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T-bet−/− RAG2−/− ulcerative colitis: The role of T-bet as a peacekeeper of host–commensal relationships [PDF]
Cytokine, 2009 Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig. 1].
Wendy S, Garrett, Laurie H, Glimcher
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T‐bet as a key regulator of mucosal immunity [PDF]
Immunology, 2016 SummaryInitially understood to be a key regulator of interferon‐γ‐producing helper T cells, our knowledge of T‐bet's functional roles has expanded to encompass a growing range of cellular lineages. In addition to regulating other interferon‐γ‐producing adaptive immune cells, it is now clear that T‐bet plays a fundamental role in the regulation of ...
Mohamed, Rami, Lord, Graham M.
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The evolving role of T-bet in resistance to infection [PDF]
Nature Reviews Immunology, 2019 The identification of T-bet as a key transcription factor associated with the development of IFNγ-producing CD4+ T cells predicted a crucial role for T-bet in cell-mediated immunity and in resistance to many intracellular infections. This idea was reinforced by initial reports showing that T-bet-deficient mice were more susceptible to pathogens that ...
Gretchen Harms, Pritchard +2 more
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