Results 41 to 50 of about 11,020,373 (290)

T-bet expression is upregulated in active Behcet's disease [PDF]

British Journal of Ophthalmology, 2003
To investigate T-bet mRNA and protein expression on peripheral blood mononuclear cells (PBMC) in patients with Behçet's disease with active uveitis.Blood samples were taken from 24 patients with Behçet's disease who had active uveitis and 16 healthy individuals. PBMC were subjected to analysis of T-bet mRNA and protein expression using semiquantitative
B, Li, P, Yang, H, Zhou, Z, Zhang, C, Xie, X, Lin, X, Huang, A, Kijlstra   +7 more
openaire   +2 more sources

Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.

, 2017
T-bet is important for differentiation of cytotoxic CD8 and Th1 CD4 T cells. We have discovered that Egr2 and 3 are potent inhibitors of T-bet function in CD4 and CD8 effector T cells.
Miao, T, Singh, R, Omodho, B, Wang, P, Symonds, AL, Li, S   +5 more
core   +2 more sources

T-bet as a possible therapeutic target in autoimmune disease [PDF]

Expert Opinion on Therapeutic Targets, 2002
The prominent role of pro-inflammatory cytokines produced by T helper-1 (T(H1)) cells in regulating autoimmune responses in vitro and in vivo has been demonstrated. Recent observations of T cell polarisation by regulatory transcription factors--especially T-bet (T-box expressed in T cells)--raise the question of their influence in controlling ...
Benno, Weigmann, Markus F, Neurath
openaire   +2 more sources

Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival

BMC Cancer, 2018
Background We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome.
Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull, Irene L. Andrulis   +7 more
doaj   +1 more source

Genetic copy number variation of TLR7, T-bet, IL12B, and FcγRIIIB in Egyptian ankylosing spondylitis patients

African Journal of Laboratory Medicine
Background: Ankylosing spondylitis (AS) is a polygenic disorder. Copy number variations (CNVs) alter the expression of TLR7, T-bet, IL-12B, and FcγRIIIB genes, contributing to AS development via their immune system roles.
Nora M. Said, Enas M. Mekkawy, Dina Said, Dina G. Abdelhamed, Alia A. El Shahawy, Eman A. Abdelaziz, Fatma Z. Kamel, Alshymaa A. Ahmed   +7 more
doaj   +1 more source

T-bet expression sustains cytolytic potential following degranulation.

, 2017
A) Flow cytometry plots of T-bet and CD107a staining in CD8+ T cells following in vitro SIV peptide (Tat-TL8 or Gag-CM9) stimulation at the indicated time points from blood and sLN.
Emily R. Roberts (3609527), Michael R. Betts (111925), Hui Li (32376), Diane G. Carnathan (234414), Guido Silvestri (94156), George M. Shaw (50361)   +5 more
core   +1 more source

IL-18 receptor marks functional CD8+ T cells in non-small cell lung cancer

OncoImmunology, 2017
IL-18 is an inflammasome-related cytokine, member of the IL-1 family, produced by a wide range of cells in response to signals by several pathogen- or damage-associated molecular patterns. It can be highly represented in tumor patients, but its relevance
Eleonora Timperi, Chiara Focaccetti, Daniela Gallerano, Mariangela Panetta, Sheila Spada, Enzo Gallo, Paolo Visca, Federico Venuta, Daniele Diso, Arsela Prelaj, Flavia Longo, Francesco Facciolo, Paola Nisticò, Vincenzo Barnaba   +13 more
doaj   +1 more source

Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells

Frontiers in Immunology, 2020
Recent reports have shown the importance of IFN-γ and T-bet+ B cells in the pathology of SLE, suggesting the involvement of IFN-γ-producing T-bet+ CD4+ cells, i.e., Th1 cells.
Shigeru Iwata, Mingzeng Zhang, Mingzeng Zhang, He Hao, He Hao, Gulzhan Trimova, Gulzhan Trimova, Maiko Hajime, Yusuke Miyazaki, Naoaki Ohkubo, Yurie Satoh Kanda, Yasuyuki Todoroki, Hiroko Miyata, Masanobu Ueno, Atsushi Nagayasu, Shingo Nakayamada, Kei Sakata, Kei Sakata, Yoshiya Tanaka   +18 more
doaj   +1 more source

T-bet binding at polymorphic sites.

, 2017
A. Heat map showing T-bet occupancy around SNPs located within T-bet binding sites (T-bet hit-SNPs). Each row is centred on a single SNP, with T-bet binding shown across the genomic region stretching 2 kb up and downstream.
Stephen Henderson (372155), Rami Mohamed (3740710), Richard G. Jenner (193140), Rimma Goldberg (3740713), Javier Herrero (10236), Lude Franke (102406), Katrina Soderquest (3740707), Graham M. Lord (471625), Arnulf Hertweck (695996), Vincent Plagnol (50600), Claudia Giambartolomei (142605), Esperanza Perucha (429856)   +11 more
core   +1 more source

Signals that drive T-bet expression in B cells [PDF]

Cellular Immunology, 2017
Transcription factors regulate various developmental and functional aspects of B cells. T-bet is a recently appreciated transcription factor associated with "Age-associated B cells" or ABCs, the development of autoimmunity, and viral infections. T-bet expression is favored by nucleic acid-containing antigens and immune complexes and is regulated by ...
Arpita, Myles, Patricia J, Gearhart, Michael P, Cancro   +2 more
openaire   +2 more sources