Results 41 to 50 of about 10,355,186 (284)

The role of BET attenuation in melanoma [PDF]

, 2022
Bromodomain and extra-terminal (BETs) proteins function as epigenetic readers by docking onto acetylated lysine residues (Kac) on histone tails via tandem bromodomains (BRDs), and recruiting protein binding partners via an extra-terminal recruitment ...
Henderson, Elizabeth K
core   +1 more source

Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival

BMC Cancer, 2018
Background We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome.
Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull, Irene L. Andrulis   +7 more
doaj   +1 more source

T-bet as a possible therapeutic target in autoimmune disease [PDF]

Expert Opinion on Therapeutic Targets, 2002
The prominent role of pro-inflammatory cytokines produced by T helper-1 (T(H1)) cells in regulating autoimmune responses in vitro and in vivo has been demonstrated. Recent observations of T cell polarisation by regulatory transcription factors--especially T-bet (T-box expressed in T cells)--raise the question of their influence in controlling ...
Benno, Weigmann, Markus F, Neurath
openaire   +2 more sources

Genetic copy number variation of TLR7, T-bet, IL12B, and FcγRIIIB in Egyptian ankylosing spondylitis patients

African Journal of Laboratory Medicine
Background: Ankylosing spondylitis (AS) is a polygenic disorder. Copy number variations (CNVs) alter the expression of TLR7, T-bet, IL-12B, and FcγRIIIB genes, contributing to AS development via their immune system roles.
Nora M. Said, Enas M. Mekkawy, Dina Said, Dina G. Abdelhamed, Alia A. El Shahawy, Eman A. Abdelaziz, Fatma Z. Kamel, Alshymaa A. Ahmed   +7 more
doaj   +1 more source

Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa [PDF]

, 2004
Background: In coeliac disease ( CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown.
PALLONE, FRANCESCO, Cucchiara, S, G. Monteleone, G. Del Vecchio Blanco, Del Vecchio Blanco, G, MONTELEONE, GIOVANNI, DEL VECCHIO BLANCO, GIOVANNA, MONTELEONE, IVAN, P. Vavassori, T. T. Macdonald, Monteleone I., Monteleone G., Del Vecchio Blanco G., Vavassori P., Cucchiara S., MacDonald T.T., Pallone F., MacDonald T. T., CUCCHIARA, Salvatore, Monteleone, I, Monteleone, G, Pallone, F, I. Monteleone, MacDonald, T, Cucchiara S., Vavassori, P, F. Pallone, Vavassori P.   +21 more
core   +1 more source

IL-18 receptor marks functional CD8+ T cells in non-small cell lung cancer

OncoImmunology, 2017
IL-18 is an inflammasome-related cytokine, member of the IL-1 family, produced by a wide range of cells in response to signals by several pathogen- or damage-associated molecular patterns. It can be highly represented in tumor patients, but its relevance
Eleonora Timperi, Chiara Focaccetti, Daniela Gallerano, Mariangela Panetta, Sheila Spada, Enzo Gallo, Paolo Visca, Federico Venuta, Daniele Diso, Arsela Prelaj, Flavia Longo, Francesco Facciolo, Paola Nisticò, Vincenzo Barnaba   +13 more
doaj   +1 more source

Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells

Frontiers in Immunology, 2020
Recent reports have shown the importance of IFN-γ and T-bet+ B cells in the pathology of SLE, suggesting the involvement of IFN-γ-producing T-bet+ CD4+ cells, i.e., Th1 cells.
Shigeru Iwata, Mingzeng Zhang, Mingzeng Zhang, He Hao, He Hao, Gulzhan Trimova, Gulzhan Trimova, Maiko Hajime, Yusuke Miyazaki, Naoaki Ohkubo, Yurie Satoh Kanda, Yasuyuki Todoroki, Hiroko Miyata, Masanobu Ueno, Atsushi Nagayasu, Shingo Nakayamada, Kei Sakata, Kei Sakata, Yoshiya Tanaka   +18 more
doaj   +1 more source

Signals that drive T-bet expression in B cells [PDF]

Cellular Immunology, 2017
Transcription factors regulate various developmental and functional aspects of B cells. T-bet is a recently appreciated transcription factor associated with "Age-associated B cells" or ABCs, the development of autoimmunity, and viral infections. T-bet expression is favored by nucleic acid-containing antigens and immune complexes and is regulated by ...
Arpita, Myles, Patricia J, Gearhart, Michael P, Cancro   +2 more
openaire   +2 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

IMMUNOTHERAPEUTIC ACTION OF T-BET GENE MODIFIED DENDRITIC CELLS [PDF]

, 2013
T-bet is a Type-1 transcription factor that regulates the development of Type-1 T cell and Type-1 anti-tumor immunity. T-bet expression in Dendritic Cells (DC) is required for the ability of these antigen-presenting cells (APC) to prime Type-1-polarized ...
Chen, Lu
core