Results 51 to 60 of about 10,355,186 (284)

Distinct Effector Programs of Brain-Homing CD8⁺ T Cells in Multiple Sclerosis

Cells, 2022
The effector programs of CD8+ memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8+ memory T cells in multiple sclerosis (MS) remains unknown. To address this, we analyzed blood, CSF
Steven C. Koetzier, Jamie van Langelaar, Marie-José Melief, Annet F. Wierenga-Wolf, Cato E. A. Corsten, Katelijn M. Blok, Cindy Hoeks, Bieke Broux, Beatrijs Wokke, Marvin M. van Luijn, Joost Smolders   +10 more
doaj   +1 more source

T-bet: a bridge between innate and adaptive immunity [PDF]

Nature Reviews Immunology, 2013
Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that ...
Lazarevic, Vanja, Glimcher, Laurie H., Lord, Graham M.   +2 more
openaire   +3 more sources

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source

Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2

Clinical and Developmental Immunology, 2012
T-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx.
Yan Xu, Jingjing Gao, Zhaoliang Su, Xiaoli Dai, Yazhen Li, Yingzhao Liu, Jianguo Chen, Jia Tong, Yun Zhang, Chaoyang Wu, Dong Zheng, Shengjun Wang, Huaxi Xu   +12 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection

, 2022
Manuscript:Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infectionBartsch et al. 2022Mouse: C57BL/6 IL17ACrexRosa26eYFPOrgan: KidneyCells: FACS-sorted CD45+CD3+CD4+eYFP+Single Cell
Yu Zhao (104852), Henning Büttner (709971), Richard Flavell (17498), Tobias B. Huber (8170776), Nikhat Shaikh (371845), Stefan Bonn (2619949), Ulf Panzer (156912), Jan-Eric Turner (469199), Holger Rohde (273755), Patricia Bartsch (9232721), Christoph Kilian (10526366), Hans-Willi Mittrücker (511801), Alina Borchers (12239163), Nicola Gagliani (193299), Christian F. Krebs (12239178), Thorsten Wiech (4102858), Malte Hellmig (12239162), Hans-Joachim Paust (9232709), Milagros N. Wong (12239172), Samuel Huber (56057), Amirrtavarshi Sivayoganathan (12239165), Leon Enk (12239166)   +21 more
core   +2 more sources

c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

eLife, 2020
RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)−17 and IL-22.
Caroline Tizian, Annette Lahmann, Oliver Hölsken, Catalina Cosovanu, Michael Kofoed-Branzk, Frederik Heinrich, Mir-Farzin Mashreghi, Andrey Kruglov, Andreas Diefenbach, Christian Neumann   +9 more
doaj   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

Frontiers in Immunology
Virus-specific CD4+ T cells typically undergo T helper (Th) 1 differentiation and contribute to a type 1 immune response in infection with lymphocytic choriomeningitis virus (LCMV).
Valerie Plajer, Valerie Plajer, Adrián Madrigal-Avilés, Adrián Madrigal-Avilés, Maria Dzamukova, Maria Dzamukova, Nayar Durán-Hernández, Nayar Durán-Hernández, Philippe Saikali, Philippe Saikali, Vivien Holecska, Vivien Holecska, Isabel Panse, Isabel Panse, Katrin Lehmann, Jinfang Zhu, Mir-Farzin Mashreghi, Mir-Farzin Mashreghi, Ahmed N. Hegazy, Ahmed N. Hegazy, Caroline Peine, Caroline Peine, Max Löhning, Max Löhning   +23 more
doaj   +1 more source

Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice.

PLoS Pathogens, 2022
Protective immune responses to Chlamydia infection within the female reproductive tract (FRT) are incompletely understood. MHC class II-restricted CD4 Th1 responses are believed to be vital for bacterial clearance due to their capacity to secrete IFN-γ ...
Jordan A Rixon, Claire E Depew, Stephen J McSorley   +2 more
doaj   +1 more source