Results 71 to 80 of about 11,020,373 (290)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau +8 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2017 Background/Aims: T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human ...
Yun Xu +9 more
doaj +1 more source
T‐bet is essential for the progression of experimental autoimmune encephalomyelitis
Immunology, 2006 SummaryExperimental autoimmune encephalomyelitis (EAE) is mediated by myelin‐specific CD4+ T helper 1 (Th1) cells, while recovery from the disease is associated with the presence of Th2 cells. Here we used animals with targeted deletion of the T‐bet gene to determine its role in the progression of EAE.
Narender, Nath +4 more
openaire +3 more sources
mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation [PDF]
The Journal of Immunology, 2017 Abstract CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. To test this hypothesis, we employed targeted mass-
Olesya Chornoguz +6 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
wiley +1 more source
PLoS Pathogens, 2022 Protective immune responses to Chlamydia infection within the female reproductive tract (FRT) are incompletely understood. MHC class II-restricted CD4 Th1 responses are believed to be vital for bacterial clearance due to their capacity to secrete IFN-γ ...
Jordan A Rixon +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess +5 more
wiley +1 more source
Compound A inhibits T-bet transcriptional activity.
, 2013 A, EL4 cells were transfected with 9 µg of a reporter plasmid which contains T-bet response elements upstream of the luciferase gene (T-bet-RE-Luc) with or without 9 µg of T-bet and GR expression vectors.
Carla N. Castro (327064) +11 more
core +1 more source
Cell Reports, 2019 Summary: Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center (GC)
Ann Ly +14 more
doaj +1 more source
Characterization of T-Bet and Eomes in Peripheral Human Immune Cells [PDF]
Frontiers in Immunology, 2014 The T-box transcription factors T-bet and Eomesodermin (Eomes) have been well defined as key drivers of immune cell development and cytolytic function. While the majority of studies have defined the roles of these factors in the context of murine T-cells, recent results have revealed that T-bet, and possibly Eomes, are expressed in other immune cell ...
Knox, James J. +3 more
openaire +3 more sources