Results 71 to 80 of about 10,355,186 (284)
T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation. [PDF]
, 2021 The generation of lymphoid tissues during embryogenesis relies on group 3 innate lymphoid cells (ILC3) displaying lymphoid tissue inducer (LTi) activity and expressing the master transcription factor RORγt. Accordingly, RORγt-deficient mice lack ILC3 and
Willis, Claire +15 more
core +1 more source
T‐bet is essential for the progression of experimental autoimmune encephalomyelitis
Immunology, 2006 SummaryExperimental autoimmune encephalomyelitis (EAE) is mediated by myelin‐specific CD4+ T helper 1 (Th1) cells, while recovery from the disease is associated with the presence of Th2 cells. Here we used animals with targeted deletion of the T‐bet gene to determine its role in the progression of EAE.
Narender, Nath +4 more
openaire +3 more sources
mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation [PDF]
The Journal of Immunology, 2017 Abstract CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. To test this hypothesis, we employed targeted mass-
Olesya Chornoguz +6 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survivorship care plans (SCPs) summarize cancer treatment and guide risk‐based follow‐up for cancer survivors, yet remain difficult to create, share, and use. Stakeholder perspectives are needed to inform usable approaches.
Molly S. Talman +4 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source
T-bet expression sustains cytolytic potential following degranulation.
, 2017 A) Flow cytometry plots of T-bet and CD107a staining in CD8+ T cells following in vitro SIV peptide (Tat-TL8 or Gag-CM9) stimulation at the indicated time points from blood and sLN.
Emily R. Roberts (3609527) +5 more
core +1 more source
Cell Reports, 2019 Summary: Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center (GC)
Ann Ly +14 more
doaj +1 more source
Characterization of T-Bet and Eomes in Peripheral Human Immune Cells [PDF]
Frontiers in Immunology, 2014 The T-box transcription factors T-bet and Eomesodermin (Eomes) have been well defined as key drivers of immune cell development and cytolytic function. While the majority of studies have defined the roles of these factors in the context of murine T-cells, recent results have revealed that T-bet, and possibly Eomes, are expressed in other immune cell ...
Knox, James J. +3 more
openaire +3 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source
Journal of Immunology Research, 2014 T-Bet (T-box protein expressed in T cells, also called as TBX21) was originally cloned as a key transcription factor involved in the commitment of T helper (Th) cells to the Th1 lineage.
Sera Oh, Eun Sook Hwang
doaj +1 more source