Results 91 to 100 of about 10,355,186 (284)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
T-bet and EOMES expression among antigen-inexperienced memory-phenotype αβ T cells, cell numbers.
, 2019 T-bet and EOMES expression among antigen-inexperienced memory-phenotype αβ T cells, cell numbers.
Andrew Getahun (314428) +7 more
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Frontiers in Immunology, 2017 We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly,
Jennifer L. Hope +18 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Regulation of T-bet Translation in the YT Cell Line by Secondary Structures of the 5’ and 3’UTR
, 2010 自然殺手細胞 (NK cell) 是一種存在於先天免疫系統 (innate immune system) 中具有毒殺細胞能力的淋巴球，它們能夠抵禦癌細胞以及被病毒感染的細胞。目前所知NK 細胞所表現的細胞激素除了TNF-α、GM-CSF 之外，也會分別表現不同的細胞激素而分類為 type II、type 0 及 type I 三個亞群，它們表現的細胞激素分別為 IL13+ / IL5+、IL13+ / IFN-γ+、IFN-γ++。另一方面，若以細胞表面分子 CD56 來定義 NK 細胞發育的成熟度 ...
賴怡安, Lai, I-An
core
, 2019 T-bet and EOMES expression among antigen-inexperienced memory-phenotype αβ T cells, cell frequencies.
Andrew Getahun (314428) +7 more
core +1 more source
The Calculus of Integrating Differentiation: Timing Control of T-Bet [PDF]
Immunity, 2009 In this issue of Immunity, Schulz et al. (2009) use mathematical modeling to elucidate a signaling network controlling Ifng gene expression, thereby showing the importance of an Interleukin-12-dependent, Interferon-gamma-independent second phase of inducing the transcription factor T-bet.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source