Results 111 to 120 of about 11,020,373 (290)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2008 目的包装携带人T细胞转录因子T-bet基因的重组腺病毒,为研究T-bet在人鼻黏膜中作用的分子机制奠定基础。方法采用RT-PCR方法从健康人PBMC中扩增出转录因子T-bet的cDNA序列,构建重组穿梭载体pDC316-T-bet;采用阳离子脂质体介导将重组穿梭载体pDC316 T-bet与pBHGloxΔE1,3C re质粒共转染293细胞,包装出携带T-bet基因的重组腺病毒rAdT-bet,空斑纯化,PCR鉴定阳性rAdT-bet。结果以空斑纯化后的rAdT-bet为模板 ...
孙克巍 +4 more
doaj
, 2018 AT-box-containing protein expressed in T cells (T-bet) is a key transcription factor involved in the regulation of Th cell differentiation. Although T-bet-deficient CD4+ T cells fail to produce IFN-γ and typically differentiate into Th2 cells in vitro ...
황은숙
core +1 more source
Ikaros Silences T-bet Expression and Interferon-γ Production during T Helper 2 Differentiation [PDF]
, 2010 CD4+ T cells can be instructed by nonantigen-specific signals to differentiate into functionally distinct lineages with mutually exclusive patterns of cytokine production.
Taylor, J. +6 more
core +1 more source
T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
Nature Communications, 2016 How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 ...
Thomas Krausgruber +9 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
In Search of a Fair Bet in the Lottery [PDF]
Although state-operated lotto games have the worst average expected payoffs among common games of chance, because the jackpot can accumulate, the maximum expected payoff is potentially unlimited.
Kent Grote, Victor Matheson
core +2 more sources
Frontiers in Immunology, 2015 The T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive ...
Jaya eKumari +9 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Frequencies of γδ T cells expressing transcription factors EOMES and/or T-bet.
, 2019 At indicated time points, three to five animals were subjected to necropsy. After preparation of single cell suspensions from nasal mucosa and BAL, flow cytometric analyses were performed to determine frequency of T-bet+/EOMES-, T-bet+/EOMES+ and T-bet ...
Theresa Schwaiger (6849761) +9 more
core +1 more source