A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment [PDF]
Cell, 2000 Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 cytokine, IFNgamma. T-bet expression correlates with IFNgamma expression in Th1 and NK cells.
Laurie Glimcher +2 more
exaly +5 more sources
Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation [PDF]
Frontiers in Immunology, 2019 Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation. Previous studies suggest transcription factor T-bet plays an important role in inflammatory arthritis.
Qi-Bin Yang +5 more
doaj +5 more sources
Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria [PDF]
Cell Reports, 2019 Summary: Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center (GC)
Ann Ly +14 more
doaj +4 more sources
Identification and Characterization of a Master Transcription Factor of Th1 Cells, T-bet, Within Flounder (Paralichthys olivaceus) [PDF]
Frontiers in Immunology, 2021 T-bet, a T-box family member, is a transcription factor essential for the differentiation of naive CD4+ T cells into Th1 cells that are involved in both innate and adaptive immune responses.
Hongfei Tian +8 more
doaj +3 more sources
The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation [PDF]
Immunity, 2012 Natural killer (NK) cells play critical roles defending against tumors and pathogens. We show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop NK cells. Developmental stability of immature NK cells constitutively expressing the death ligand TRAIL depended on T-bet.
Joseph Sun +2 more
exaly +3 more sources
Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells [PDF]
Genes and Immunity, 2008 T-box transcription factor, T-bet, has a central role in the differentiation of T-helper (Th) progenitor cells to Th1 or Th2 effector cells, partly by regulating the expression of genes such as interferon-gamma (IFN-gamma). However, the direct target genes, especially those mediating the transcriptional network initiated by T-bet, are not yet fully ...
Shinjiro Hamano, M Sonoda, K Furuno
exaly +3 more sources
Identification of the T-box transcription factor t-bet in chickens and its role in immune response
Poultry ScienceT-bet (T-box transcription factor TBX21), encoded by the Tbx21 gene, is a key regulator of T helper 1 (Th1) cell differentiation and cellular immunity. However, the role of T-bet in avian species remains elusive. To investigate the role of T-bet in avian
Yuxin Guo +9 more
doaj +4 more sources
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells [PDF]
Immunity, 2019 Christopher Scharer +2 more
exaly +2 more sources
T-bet: biological functions, molecular mechanisms, and therapeutic applications: a systematic review [PDF]
Frontiers in ImmunologyT-bet is a transcription factor predominantly expressed in immune cells, and it has been associated with a range of physiological and pathological processes, including the differentiation of various immune cell types, the development of immune-related ...
Xiaowen Yang +4 more
doaj +2 more sources
The Th1 cell regulatory circuitry is largely conserved between human and mouse
Life Science Alliance, 2021 Comparison of the binding sites of the Th1 lineage-specifying transcription factor T-bet between human and mouse reveals differences in binding sites but that the most of the target genes are shared.
Stephen Henderson +6 more
doaj +1 more source