Results 21 to 30 of about 14,321,563 (290)

T-bet syndrome-associated bronchial asthma phenotype

Медицинская иммунология, 2020
We aimed to evaluate a significance of T-bet transcription factor in bronchial asthma (BA). A total of 102 patients with BA were examined. The control group was represented by healthy subjects (21 people).
L. N. Sorokina, V. N. Mineev, A. V. Eremeeva, M. A. Nyoma   +3 more
doaj   +1 more source

A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

Cell Reports, 2023
Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions.
Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B. Wing, Shimon Sakaguchi, Masahiro Yamamoto   +7 more
doaj   +1 more source

Expression Regulation and Function of T-Bet in NK Cells

Frontiers in Immunology, 2021
Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is ...
Chen Huang, Jiacheng Bi
doaj   +1 more source

Stability and function of regulatory T cells expressing the transcription factor T-bet [PDF]

Nature, 2017
Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (TH1), TH2, and TH17) defined by expression of the key transcription factors T-bet, GATA3, and RORγt, respectively.
Levine, Andrew G., Medoza, Alejandra, Hemmers, Saskia, Moltedo, Bruno, Niec, Rachel E., Schizas, Michail, Hoyos, Beatrice E., Putintseva, Ekaterina V., Chaudhry, Ashutosh, Dikiy, Stanislav, Fujisawa, Sho, Chudakov, Dmitriy M., Treuting, Piper M., Rudensky, Alexander Y.   +13 more
openaire   +2 more sources

Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells

Frontiers in Immunology, 2023
The T-box transcription factors T-bet and Eomesodermin regulate type 1 immune responses in innate and adaptive lymphocytes. T-bet is widely expressed in the immune system but was initially identified as the lineage-specifying transcription factor of Th1 ...
Benedikt Thelen, Vincent Schipperges, Paulina Knörlein, Jonas F. Hummel, Frederic Arnold, Frederic Arnold, Frederic Arnold, Laurence Kupferschmid, Christoph S. N. Klose, Sebastian J. Arnold, Sebastian J. Arnold, Melanie Boerries, Melanie Boerries, Yakup Tanriver, Yakup Tanriver   +14 more
doaj   +1 more source

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

Cell Reports, 2019
Summary: Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular helper (TFH) cells express the prototypical T helper 1 transcription factor T-bet ...
Amania A. Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C. Duckworth, Nicholas D. Huntington, James J. Moon, Marc Pellegrini, Stephen L. Nutt, Gabrielle T. Belz, Kim L. Good-Jacobson, Joanna R. Groom   +12 more
doaj   +1 more source

T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

Cell Reports, 2022
Summary: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB.
Nicole L. Grant, Pauline Maiello, Edwin Klein, Philana Ling Lin, H. Jacob Borish, Jaime Tomko, L. James Frye, Alexander G. White, Denise E. Kirschner, Joshua T. Mattila, JoAnne L. Flynn   +10 more
doaj   +1 more source

IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet [PDF]

The Journal of Immunology, 2013
Abstract CD8+ T cells are fundamental for immune-mediated clearance of viral infections and contribute to immune pathology in autoimmune diseases such as type 1 diabetes. To execute these functions, CD8+ T cells must differentiate into CTLs, a process that is precisely regulated by a variety of cytokines, costimulatory molecules, and ...
Andrew P R, Sutherland, Nicole, Joller, Monia, Michaud, Sue M, Liu, Vijay K, Kuchroo, Michael J, Grusby   +5 more
openaire   +2 more sources

T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of RORγt expression and function

Scientific Reports, 2021
T-bet is a key transcription factor for the T helper 1 lineage and its expression level is negatively correlated to inflammation in patients with rheumatoid arthritis (RA).
Masaru Shimizu, Yuya Kondo, Reona Tanimura, Kotona Furuyama, Masahiro Yokosawa, Hiromitsu Asashima, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida   +8 more
doaj   +1 more source

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity [PDF]

Journal of Clinical Investigation, 2017
B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a promising strategy for treating autoimmune disorders. Better understanding of the B cell subsets that are responsible for the development of autoimmunity will be critical for developing efficient therapies.
Kira, Rubtsova, Anatoly V, Rubtsov, Joshua M, Thurman, Johanna M, Mennona, John W, Kappler, Philippa, Marrack   +5 more
openaire   +2 more sources