The immune cell transcription factor T-bet [PDF]
Adipocyte, 2013 Obesity-associated insulin resistance is accompanied by an alteration in the Th1/Th2 balance in adipose tissue. T-bet (Tbx21) is an immune cell transcription factor originally described as the master regulator of Th1 cell development, although is now recognized to have a role in both the adaptive and innate immune systems.
Stolarczyk, Emilie +2 more
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Transcription Factor T-bet Regulates Intraepithelial Lymphocyte Functional Maturation [PDF]
Immunity, 2014 The intestinal epithelium harbors large populations of activated and memory lymphocytes, yet these cells do not cause tissue damage in the steady state. We investigated how intestinal T cell effector differentiation is regulated upon migration to the intestinal epithelium. Using gene loss- and gain-of-function strategies, as well as reporter approaches,
Reis, Bernardo S. +3 more
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Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa [PDF]
Gut, 2004 Background: In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown. Aims:
MONTELEONE, IVAN +6 more
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The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1 [PDF]
Frontiers in Immunology, 2017 We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly,
Jennifer L. Hope +18 more
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Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor T-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis [PDF]
Mediators of Inflammation, 2015 Sarcoidosis is an inflammatory granulomatous disease with unknown etiology driven by cytokines and chemokines. There is limited information regarding the regulation of cytokine/chemokine-receptor network in bronchoalveolar lavage (BAL) cells in pulmonary
Tereza Dyskova +7 more
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Transcription factor T-bet in Atlantic salmon: Characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection [PDF]
Frontiers in Immunology, 2015 The T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive ...
Jaya eKumari +9 more
doaj +3 more sources
The activated glucocorticoid receptor inhibits the transcription factor T‐bet by direct protein‐protein interaction [PDF]
The FASEB Journal, 2007 ABSTRACT Glucocorticoids (GCs) immunosuppression acts via regulation of several transcription factors (TF), including activating protein (AP)‐1, NF‐κB, and NFAT. GCs inhibit Th1 cytokines and promote a shift toward Th2 differentiation. Th1 phenotype depends on TF T‐bet.
Liberman, Ana Clara +6 more
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T‐bet, a Th1 transcription factor regulates the expression of Tim‐3 [PDF]
European Journal of Immunology, 2010 AbstractT‐cell immunoglobulin, mucin domain‐3 (Tim‐3) is a membrane protein expressed at late stages of IFN‐γ secreting CD4+ Th1 cell differentiation and constitutively on DC. Ligation of Tim‐3 on Th1 cells terminates Th1 immune responses. In addition, Tim‐3 plays a role in tolerance induction, although the mechanism by which this is accomplished has ...
Anderson, Ana C +6 more
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The zinc finger transcription factor Early Growth Response 2 (Egr-2) is an intrinsic regulator of T cell tolerance and homeostasis [PDF]
, 2009 PhDTolerance of T cells to self-antigen is crucial to prevent the development of autoimmune disease. How self-tolerance is controlled at the transcriptional level is, however, unknown. We discovered that the transcription factor Early Growth Response 2
Symonds, Alistair
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Endothelial injury in transplant glomerulopathy is correlated with transcription factor T-bet expression [PDF]
Kidney International, 2012 Transplant glomerulopathy is an important cause of late graft loss. Inflammatory lesions including glomerulitis and peritubular capillaritis, suggestive of endothelial injury, are prominent in this condition but the mechanism underlying this inflammation remains unclear.
Sun, Qiquan +6 more
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