Results 31 to 40 of about 14,321,563 (290)

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation [PDF]

, 2012
SummaryThe evolutionary conserved Foxo transcription factors are important regulators of quiescence and longevity. Although, Foxo1 is known to be important in regulating CD8+ T cell trafficking and homeostasis, its role in functional differentiation of ...
Bupp, Melanie R. Gubbels, Shrikant, Protul A., Rao, Rajesh R., Li, Qingsheng   +3 more
core   +1 more source

Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2006
The reasons for variable sensitivity among and within species to lung injury and fibrosis caused by bleomycin (BLM) are unknown. Because T helper (Th) 1 and 2 (Th1 and Th2) polarization of CD4+T lymphocytes is one of the factors that affects the BLM response, we hypothesized that preventing expression of the Th1 transcription factor T-bet would render ...
Jianguo, Xu, Ana L, Mora, John, LaVoy, Kenneth L, Brigham, Mauricio, Rojas   +4 more
openaire   +2 more sources

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +2 more sources

T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

Cell Reports, 2016
The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood.
Arnulf Hertweck, Catherine M. Evans, Malihe Eskandarpour, Jonathan C.H. Lau, Kristine Oleinika, Ian Jackson, Audrey Kelly, John Ambrose, Peter Adamson, David J. Cousins, Paul Lavender, Virginia L. Calder, Graham M. Lord, Richard G. Jenner   +13 more
doaj   +1 more source

Erratum: Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet [PDF]

Nature, 2017
This corrects the article DOI: 10.1038/nature22360.
Andrew G, Levine, Alejandra, Mendoza, Saskia, Hemmers, Bruno, Moltedo, Rachel E, Niec, Michail, Schizas, Beatrice E, Hoyos, Ekaterina V, Putintseva, Ashutosh, Chaudhry, Stanislav, Dikiy, Sho, Fujisawa, Dmitriy M, Chudakov, Piper M, Treuting, Alexander Y, Rudensky   +13 more
openaire   +2 more sources

Signal Transducer and Activator of Transcription 4 Is Required for the Transcription Factor T-bet to Promote T Helper 1 Cell-Fate Determination [PDF]

, 2008
SummaryTranscriptional regulatory networks direct the development of specialized cell types. The transcription factors signal tranducer and activator of transcription 4 (Stat4) and T-bet are required for the interleukin-12 (IL-12)-stimulated development ...
Chang, Hua-Chen, Yu, Qing, Kaplan, Mark H., Yeh, Norman, Nguyen, Evelyn T., Thieu, Vivian T., Sehra, Sarita   +6 more
core   +1 more source

T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

Nature Communications, 2016
How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 ...
Thomas Krausgruber, Chris Schiering, Krista Adelmann, Oliver J. Harrison, Agnieszka Chomka, Claire Pearson, Philip P. Ahern, Matthew Shale, Mohamed Oukka, Fiona Powrie   +9 more
doaj   +1 more source

T-bet-dependent ILC1- and NK cell-derived IFN-γ mediates cDC1-dependent host resistance against Toxoplasma gondii.

PLoS Pathogens, 2021
Host resistance against intracellular pathogens requires a rapid IFN-γ mediated immune response. We reveal that T-bet-dependent production of IFN-γ is essential for the maintenance of inflammatory DCs at the site of infection with a common protozoan ...
Américo H López-Yglesias, Elise Burger, Ellie Camanzo, Andrew T Martin, Alessandra M Araujo, Samantha F Kwok, Felix Yarovinsky   +6 more
doaj   +1 more source

Transcription factor T-bet is a diagnostic marker for necrotizing enterocolitis development in premature newborns

Modern pediatrics. Ukraine, 2022
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease that mainly affects preterm infants. The non-specificity of the clinical picture and the high percentage of complications determine the need for early diagnosis and prevention of the disease.
O.E. Abaturov, A.O. Tovarnytska
openaire   +3 more sources

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

Cell Reports, 2017
Summary: Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate ...
Dana Piovesan, Jessica Tempany, Andrea Di Pietro, Inge Baas, Callisthenis Yiannis, Kristy O’Donnell, Yunshun Chen, Victor Peperzak, Gabrielle T. Belz, Charles R. Mackay, Gordon K. Smyth, Joanna R. Groom, David M. Tarlinton, Kim L. Good-Jacobson   +13 more
doaj   +1 more source