Results 51 to 60 of about 14,321,563 (290)

Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells [PDF]

Journal of Clinical Investigation, 2006
The transcription factor T-bet (Tbx21) plays a major role in adaptive immunity and is required for optimal IFN-gamma production by DCs. Here we demonstrate an essential function for T-bet in DCs in controlling inflammatory arthritis. We show that collagen antibody-induced arthritis (CAIA), a model of human RA, is a bipartite disease characterized by an
Jingsong, Wang, John W, Fathman, Geanncarlo, Lugo-Villarino, Lucila, Scimone, Ulrich, von Andrian, David M, Dorfman, Laurie H, Glimcher   +6 more
openaire   +2 more sources

Bayesian model-based inference of transcription factor activity [PDF]

, 2007
<b>Background:</b> In many approaches to the inference and modeling of regulatory interactions using microarray data, the expression of the gene coding for the transcription factor is considered to be an accurate surrogate for the true ...
Rogers, S, Girolami, M, Rogers, Simon, Girolami, Mark, Khanin, R, Khanin, Raya   +5 more
core   +1 more source

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

PLoS Genetics, 2017
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity.
Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Claudia Giambartolomei, Stephen Henderson, Rami Mohamed, Rimma Goldberg, Esperanza Perucha, Lude Franke, Javier Herrero, Vincent Plagnol, Richard G Jenner, Graham M Lord   +12 more
doaj   +1 more source

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells [PDF]

, 2012
This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Copyright @ 2012 Elsevier Inc.Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However,
Miao, T, Bhullar, P, Ghaffari, Emma, Liu, Mengya, Liu, M, Wang, Ping, Miao, Tizong, Li, Suling, Wang, P, Sebastian, M, Ghaffari, E, Sebastian, Meera, Symonds, Alistair L.J., Li, S, Symonds, ALJ, Bhullar, Punamdip   +15 more
core   +1 more source

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway [PDF]

Nature Immunology, 2013
NKp46+ innate lymphoid cells (ILCs) serve important roles in regulating the intestinal microbiota and defense against pathogens. Whether NKp46+ ILCs arise directly from lymphoid tissue-inducer (LTi) cells or represent a separate lineage remains controversial.
Rankin, Lucille C., Groom, Joanna R., Chopin, Michael, Herold, Marco J., Walker, Jennifer A., Mielke, Lisa A., McKenzie, Andrew N. J., Carotta, Sebastian, Nutt, Stephen L., Belz, Gabrielle T.   +9 more
openaire   +4 more sources

T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis

Frontiers in Immunology, 2020
Background: Interferon-gamma (IFN-γ) is a key mediator of sarcoidosis-related granulomatous inflammation. Previous findings of IFN-γ-producing Th17 cells in bronchoalveolar lavage fluid from sarcoidosis patients invokes the transition of Th17.0 cells to ...
Nicholas K. Arger, Siddharth Machiraju, Isabel E. Allen, Prescott G. Woodruff, Laura L. Koth   +4 more
doaj   +1 more source

IMMUNOTHERAPEUTIC ACTION OF T-BET GENE MODIFIED DENDRITIC CELLS [PDF]

, 2013
T-bet is a Type-1 transcription factor that regulates the development of Type-1 T cell and Type-1 anti-tumor immunity. T-bet expression in Dendritic Cells (DC) is required for the ability of these antigen-presenting cells (APC) to prime Type-1-polarized ...
Chen, Lu
core  

Immune regulation of herpes simplex virus type 2 infection: Special emphasis on the transcription factor T-bet [PDF]

, 2007
Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa as well as local sensory neurons. It is the most common cause of genital ulcer disease in humans.
Bellner, Lars,, Magnusson, Mattias,, Mattias Magnusson, Svensson, Alexandra,, Lars Bellner, Kristina Eriksson, Eriksson, Kristina,, Svensson, Alexandra, Alexandra Svensson   +8 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

Cell Reports, 2016
Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across ...
Yue Zhao, Qi Liu, Pankaj Acharya, Kristy R. Stengel, Quanhu Sheng, Xiaofan Zhou, Hojoong Kwak, Melissa A. Fischer, James E. Bradner, Stephen A. Strickland, Sanjay R. Mohan, Michael R. Savona, Bryan J. Venters, Ming-Ming Zhou, John T. Lis, Scott W. Hiebert   +15 more
doaj   +1 more source