Results 31 to 40 of about 10,355,186 (284)

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

Cell Reports, 2019
Summary: Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular helper (TFH) cells express the prototypical T helper 1 transcription factor T-bet ...
Amania A. Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C. Duckworth, Nicholas D. Huntington, James J. Moon, Marc Pellegrini, Stephen L. Nutt, Gabrielle T. Belz, Kim L. Good-Jacobson, Joanna R. Groom   +12 more
doaj   +1 more source

T-bet Orchestrates CD8αα IEL Differentiation [PDF]

Immunity, 2014
Very little is known about the transcription factor network that regulates the development of intestinal intraepithelial lymphocytes (IELs). In this issue of Immunity, Klose et al. (2014b) and Reis et al. (2014) demonstrate an essential role for T-bet in regulating the CD8αα IEL differentiation program.
Kwong, Brandon, Lazarevic, Vanja
openaire   +2 more sources

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. [PDF]

PLoS ONE, 2013
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
Gang Li, Qianting Yang, Yibei Zhu, Hong-Rui Wang, Xinchun Chen, Xueguang Zhang, Binfeng Lu   +6 more
doaj   +1 more source

T-Bet Polymorphisms are Associated with Asthma and Airway Hyperresponsiveness [PDF]

American Journal of Respiratory and Critical Care Medicine, 2006
Abstract Rationale T-bet (TBX21 or T-box 21) is a critical regulator of T-helper 1 lineage commitment and IFN-γ production. Knockout mice lacking T-bet develop airway hyperresponsiveness (AHR) to methacholine, peribronchial eosinophilic and lymphocytic inflammation, and increased type III ...
Raby, B. A., Hwang, E. S., Van Steen, Kristel, Tantisira, K., Peng, S., Litonjua, A., Lazarus, R., Giallourakis, C., Rioux, J. D., Sparrow, D., Silverman, E. K., Glimcher, L. H., Weiss, S. T.   +12 more
openaire   +2 more sources

Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation

Frontiers in Immunology, 2019
Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation. Previous studies suggest transcription factor T-bet plays an important role in inflammatory arthritis.
Qi-Bin Yang, Yong-Long He, Yong-Long He, Quan-Bo Zhang, Qing-Sheng Mi, Jing-Guo Zhou   +5 more
doaj   +1 more source

T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells

Frontiers in Immunology, 2022
Type 3 innate lymphoid cells (ILC3s) are characterized by RORγt expression and they produce IL-22 upon activation. ILC3s play a role in maintenance of barrier integrity in the intestine.
Laura Kiekens, Laura Kiekens, Sigrid Wahlen, Sigrid Wahlen, Eva Persyn, Eva Persyn, Zenzi De Vos, Zenzi De Vos, Tom Taghon, Tom Taghon, Bart Vandekerckhove, Bart Vandekerckhove, Georges Leclercq, Georges Leclercq   +13 more
doaj   +1 more source

The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection

Clinical and Developmental Immunology, 2013
Background. Previous data showed that the predominance of intraglomerular T-bet or GATA3 is correlated with different mechanisms of rejection, suggesting that the ratio of T-bet/GATA3 might be used to distinguish antibody-mediated rejection (ABMR) and T ...
Xue Li, Qiquan Sun, Mingchao Zhang, Jinsong Chen, Zhihong Liu   +4 more
doaj   +1 more source

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells

Frontiers in Immunology, 2021
T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and EOMES expression results in dysfunctional NK cells and failure to control tumor growth. In contrast
Laura Kiekens, Laura Kiekens, Wouter Van Loocke, Wouter Van Loocke, Sylvie Taveirne, Sylvie Taveirne, Sigrid Wahlen, Sigrid Wahlen, Eva Persyn, Eva Persyn, Els Van Ammel, Els Van Ammel, Zenzi De Vos, Zenzi De Vos, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Tom Taghon, Pieter Van Vlierberghe, Pieter Van Vlierberghe, Bart Vandekerckhove, Bart Vandekerckhove, Georges Leclercq, Georges Leclercq   +23 more
doaj   +1 more source

T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells

Frontiers in Immunology, 2021
Innate lymphoid cells (ILC) play a significant immunological role at mucosal surfaces such as the intestine. T-bet-expressing group 1 innate lymphoid cells (ILC1) are believed to play a substantial role in inflammatory bowel disease (IBD).
Jan-Hendrik Schroeder, Katrin Meissl, Dominika Hromadová, Jonathan W. Lo, Jonathan W. Lo, Joana F. Neves, Jane K. Howard, Helena Helmby, Nick Powell, Birgit Strobl, Graham M. Lord, Graham M. Lord   +11 more
doaj   +1 more source

T-bet expression is upregulated in active Behcet's disease [PDF]

British Journal of Ophthalmology, 2003
To investigate T-bet mRNA and protein expression on peripheral blood mononuclear cells (PBMC) in patients with Behçet's disease with active uveitis.Blood samples were taken from 24 patients with Behçet's disease who had active uveitis and 16 healthy individuals. PBMC were subjected to analysis of T-bet mRNA and protein expression using semiquantitative
B, Li, P, Yang, H, Zhou, Z, Zhang, C, Xie, X, Lin, X, Huang, A, Kijlstra   +7 more
openaire   +2 more sources