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, 2019 9th Bet Debora Conference "Jewish Women: Being Present, Bringing Change" covered following topics: contemporary women’s perspectives on Jewish tradition; advocacy for other minority groups: activism against antisemitism, antiziganism, racism, and ...
core +6 more sources
Cell Reports, 2019 Summary: Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular helper (TFH) cells express the prototypical T helper 1 transcription factor T-bet ...
Amania A. Sheikh +12 more
doaj +1 more source
T-bet Orchestrates CD8αα IEL Differentiation [PDF]
Immunity, 2014 Very little is known about the transcription factor network that regulates the development of intestinal intraepithelial lymphocytes (IELs). In this issue of Immunity, Klose et al. (2014b) and Reis et al. (2014) demonstrate an essential role for T-bet in regulating the CD8αα IEL differentiation program.
Kwong, Brandon, Lazarevic, Vanja
openaire +2 more sources
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. [PDF]
PLoS ONE, 2013 Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
Gang Li +6 more
doaj +1 more source
T-Bet Polymorphisms are Associated with Asthma and Airway Hyperresponsiveness [PDF]
American Journal of Respiratory and Critical Care Medicine, 2006 Abstract Rationale T-bet (TBX21 or T-box 21) is a critical regulator of T-helper 1 lineage commitment and IFN-γ production. Knockout mice lacking T-bet develop airway hyperresponsiveness (AHR) to methacholine, peribronchial eosinophilic and lymphocytic inflammation, and increased type III ...
Raby, B. A. +12 more
openaire +2 more sources
T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells
Frontiers in Immunology, 2022 Type 3 innate lymphoid cells (ILC3s) are characterized by RORγt expression and they produce IL-22 upon activation. ILC3s play a role in maintenance of barrier integrity in the intestine.
Laura Kiekens +13 more
doaj +1 more source
T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells
Frontiers in Immunology, 2021 T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and EOMES expression results in dysfunctional NK cells and failure to control tumor growth. In contrast
Laura Kiekens +23 more
doaj +1 more source
The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice [PDF]
, 2017 Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag-/- mice requires expression of the transcription factor T-bet by the T cells.
Riedel, René +39 more
core +2 more sources
Frontiers in Immunology, 2019 Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation. Previous studies suggest transcription factor T-bet plays an important role in inflammatory arthritis.
Qi-Bin Yang +5 more
doaj +1 more source
T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells
Frontiers in Immunology, 2021 Innate lymphoid cells (ILC) play a significant immunological role at mucosal surfaces such as the intestine. T-bet-expressing group 1 innate lymphoid cells (ILC1) are believed to play a substantial role in inflammatory bowel disease (IBD).
Jan-Hendrik Schroeder +11 more
doaj +1 more source