Revisiting the Th1/Th2 Paradigm [PDF]
Scandinavian Journal of Immunology, 1998 The identification of subsets of CD4 + helper cells producing distinct pattern of cytokines has provided a valuable framework for understanding how different effector populations of immune cells can be recruited in vivo during infection.
Muraille, Eric, Leo, Oberdan
openaire +3 more sources
Markers of Th1 polarized Th17 cells (literature review) [PDF]
Acta Biomedica Scientifica, 2023 T helpers (Th) producing IL-17 (Th17) have high plasticity and under the influence of external conditions are able to redifferentiate into cells with a different phenotype, primarily in Th1-lymphocytes, forming a population that combines the ...
E. M. Kuklina, N. S. Glebezdina
doaj +2 more sources
Enhanced Rg3 negatively regulates Th1 cell responses
Journal of Ginseng Research, 2019 Background: Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities.
Minkyoung Cho +3 more
doaj +2 more sources
Common Features of Regulatory T Cell Specialization During Th1 Responses [PDF]
Frontiers in Immunology, 2018 CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control ...
Katharina Littringer +14 more
doaj +2 more sources
Gut Microbiota-Derived Indole-3-Acetaldehyde Contributes to the Disease-Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis. [PDF]
Adv Sci (Weinh)Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Han X +11 more
europepmc +2 more sources
Th1-cell epitopes predicted for the Mtb antigens.
, 2022 Th1-cell epitopes predicted for the Mtb antigens.
Mohsina Akhter (13883935) +3 more
core +1 more source
The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype. [PDF]
, 2003 T helper cell (Th1 and Th2) associated responses were examined following a primary infection with the gastrointestinal nematode Heligmosomoides polygyrus in five inbred strains of mice with different resistance phenotypes.
Lammas, David +7 more
core +1 more source
Th1 cytokines are essential for placental immunity to Listeria monocytogenes [PDF]
, 2005 The fetal allograft poses an immunological challenge: how is it protected while immunity to pathogens, particularly those that replicate in the placenta, is maintained?
Pollard, Jeffrey W +5 more
core +1 more source
Lymphocyte subsets and the role of Th1/Th2 balance in stressed chronic pain patients [PDF]
, 2007 Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of ...
Beyer, Antje +7 more
core +1 more source
In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]
, 2002 We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M. +38 more
core +1 more source