Results 21 to 30 of about 198,196 (300)

Interactomic inhibition of Eomes in the nucleus alleviates EAE via blocking the conversion of Th17 cells into non-classic Th1 cells

Immunological Medicine, 2022
Th17 cells are implicated in the pathogenesis of several autoimmune diseases. During the inflammation, Th17 cells exposed to IL-12 can shift towards the Th1 phenotype. These shifted cells are defined as ‘non-classic Th1 cells’.
Bo-Young Shin, Su-Hyeon Lee, Yuna Kim, Jaekyeung An, Tae-Yoon Park, Sang-Kyou Lee   +5 more
doaj   +1 more source

Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells

Frontiers in Immunology, 2022
Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th-cell lineages, hybrid phenotypes such
Philipp Burt, Philipp Burt, Michael Peine, Michael Peine, Caroline Peine, Caroline Peine, Zuzanna Borek, Zuzanna Borek, Zuzanna Borek, Sebastian Serve, Sebastian Serve, Sebastian Serve, Michael Floßdorf, Ahmed N. Hegazy, Ahmed N. Hegazy, Ahmed N. Hegazy, Thomas Höfer, Max Löhning, Max Löhning, Kevin Thurley, Kevin Thurley, Kevin Thurley   +21 more
doaj   +1 more source

IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection

, 2020
Inflammation is critical for controlling pathogens, but also responsible for symptoms of infectious diseases. IL-27 is an important regulator of inflammation and can limit development of IFNγ-producing Tbet+ CD4+ T (Th1) cells.
Edwards, Chelsea L, Uzonna, Jude E, Frame, Teija CM, Ng, Susanna S, Wang, Yulin, Kabat, Agnieszka, Kuns, Rachel D, Winterford, Clay, de Labastida Rivera, Fabian, Engwerda, Christian R, Amante, Fiona H, Montes de Oca, Marcela, Zhang, Ping, et al., Bukali, Luzia   +14 more
core   +1 more source

IL-2–mTORC1 signaling coordinates the STAT1/T-bet axis to ensure Th1 cell differentiation and anti-bacterial immune response in fish

PLoS Pathogens, 2022
Utilization of specialized Th1 cells to resist intracellular pathogenic infection represents an important innovation of adaptive immunity. Although transcriptional evidence indicates the potential presence of Th1-like cells in some fish species, the ...
Kete Ai, Kang Li, Xinying Jiao, Yu Zhang, Jiaqi Li, Qian Zhang, Xiumei Wei, Jialong Yang   +7 more
doaj   +2 more sources

The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis

Turkish Archives of Otorhinolaryngology, 2015
Objective:With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and ...
Erol Keleş, Şule Özkara, Nevin İlhan, Hilal Güngör, Turgut Karlıdağ, Şinasi Yalçın   +5 more
doaj   +1 more source

CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter

Cell Reports, 2021
Summary: Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must efficiently locate antigen-presenting cells (APC) for peripheral activation.
Hen Prizant, Nilesh Patil, Seble Negatu, Noor Bala, Alexander McGurk, Scott A. Leddon, Angela Hughson, Tristan D. McRae, Yu-Rong Gao, Alexandra M. Livingstone, Joanna R. Groom, Andrew D. Luster, Deborah J. Fowell   +12 more
doaj   +1 more source

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.

PLoS ONE, 2010
BackgroundThere is consensus that experimental autoimmune encephalomyelitis (EAE) can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the contribution of either subset to the pathogenic process has remained controversial ...
Helena S Domingues, Marsilius Mues, Hans Lassmann, Hartmut Wekerle, Gurumoorthy Krishnamoorthy   +4 more
doaj   +1 more source

Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis

JCI Insight, 2021
Oligoarticular juvenile idiopathic arthritis (oligo JIA) is the most common form of chronic inflammatory arthritis in children, yet the cause of this disease remains unknown. To understand immune responses in oligo JIA, we immunophenotyped synovial fluid
Amélie M. Julé, Kacie J. Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, Maria L. Taylor, Julie Ng, James A. Lederer, Siobhan M. Case, Margaret H. Chang, Ezra M. Cohen, Fatma Dedeoglu, Melissa M. Hazen, Jonathan S. Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, Mindy S. Lo, Esra Meidan, Jordan E. Roberts, Mary Beth F. Son, Robert P. Sundel, Pui Y. Lee, Talal Chatila, Peter A. Nigrovic, Lauren A. Henderson   +24 more
doaj   +1 more source

Fludarabine Ameliorates Lupus Nephritis by Inhibiting T Cell Infiltration through STAT1 in R848-induced Mice Models

Korean Journal of Clinical Laboratory Science
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease caused by both genetic and environmental factors. Fludarabine is a selective inhibitor of signal transducer and activator of transcription 1 (STAT1). Recently, STAT1 inhibitors have been
Se Gwang JANG
doaj   +1 more source

Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease

BMC Pulmonary Medicine, 2019
Background Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental plasticity, giving rise to Th17 ...
Weihan Xu, Ruimin Li, Yongchang Sun
doaj   +1 more source