Results 11 to 20 of about 320,868 (298)

Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists [PDF]

, 2015
Alpha-Galactosyl Ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro ...
ASPESLAGH, SANDRINE, Elewaut, Dirk, Guillaume, Joren, Pauwels, Nora, Van Calenbergh, Serge, Zajonc, Dirk   +5 more
core   +1 more source

Imbalances in T Cell-Related Transcription Factors Among Patients with Hashimoto’s Thyroiditis

Sultan Qaboos University Medical Journal, 2017
Objectives: Imbalances in effector T cell functioning have been associated with a number of autoimmune diseases, including Hashimoto’s thyroiditis (HT).
Vahid Safdari, Ebrahim Alijani, Maryam Nemati, Abdollah Jafarzadeh   +3 more
doaj   +1 more source

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]

, 2014
During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne, Chen, Jonathan H, Cui, Weiguo, Kaech, Susan M, Laidlaw, Brian J, Lang, Philipp A, Marshall, Heather D, Ohashi, Pamela, Parish, Ian A, Perry, Curtis, Staron, Matthew M, Tsui, Yao-Chen, Weaver, Casey T   +12 more
core   +1 more source

Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis

Autoimmunity, 2017
Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease.
Weshely Kujur, Rama Krishna Gurram, Sudeep K. Maurya, Sajid Nadeem, Sathi Babu Chodisetti, Nargis Khan, Javed Naim Agrewala   +6 more
doaj   +1 more source

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]

, 2017
IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri, Dent, Alexander L., Hummel, Sarah A., Janga, Sarath Chandra, Kaplan, Mark H., Khan, Ibrahim, Meuris, Brice, Olson, Matthew R., Ulrich, Benjamin J.   +8 more
core   +1 more source

Molecular characterization of human CD4+ IL-10-producing regulatory cells [PDF]

, 2014
Previous studies in the group led to the identification of CD4+FOXP3- cells with regulatory functions in human blood that coproduce IL-10 and IFN-gamma.
De Simone, Marco <1975>
core   +1 more source

Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps

Radiology and Oncology, 2019
Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery.
Soklic Tanja Kosak, Rijavec Matija, Silar Mira, Koren Ana, Kern Izidor, Hocevar-Boltezar Irena, Korosec Peter   +6 more
doaj   +1 more source

Interactomic inhibition of Eomes in the nucleus alleviates EAE via blocking the conversion of Th17 cells into non-classic Th1 cells

Immunological Medicine, 2022
Th17 cells are implicated in the pathogenesis of several autoimmune diseases. During the inflammation, Th17 cells exposed to IL-12 can shift towards the Th1 phenotype. These shifted cells are defined as ‘non-classic Th1 cells’.
Bo-Young Shin, Su-Hyeon Lee, Yuna Kim, Jaekyeung An, Tae-Yoon Park, Sang-Kyou Lee   +5 more
doaj   +1 more source

Immunogenicity of targeted lentivectors [PDF]

, 2014
To increase the safety and possibly efficacy of HIV-1 derived lentivectors (LVs) as an anti-cancer vaccine, we recently developed the Nanobody (Nb) display technology to target LVs to antigen presenting cells (APCs).
Adotévi, Bennett, Bevan, Bhardwaj, Bhardwaj, Bhardwaj, Blander, Bonehill, Bonehill, Breckpot, Breckpot, Breckpot, Charleston, Chuah, Collins, Collins, Collins, Collins, Cosset, Diebold, Donckier, Eggermont, Enk, Figdor, Gajewski, Garcia, Groettrup, Inaba, Kast, Lahoutte, Lévy, McCullough, Medzhitov, Melief, Mellman, Mortha, Moser, Moser, Munn, Naldini, Neyns, Noguiez-Hellin, Nussenzweig, Palena, Raes, Reis e Sousa, Reiser, Reiser, Richardson, Romani, Roncarolo, Sakuma, Schroyens, Semesyuk, Song, Storm, Thielemans, Thielemans, Thielemans, Thielemans, Torretta, Turk, Van Kooyk, Wang, Wang, Yamaguchi, Yewdell, Yu   +67 more
core   +3 more sources

IL-2–mTORC1 signaling coordinates the STAT1/T-bet axis to ensure Th1 cell differentiation and anti-bacterial immune response in fish

PLoS Pathogens, 2022
Utilization of specialized Th1 cells to resist intracellular pathogenic infection represents an important innovation of adaptive immunity. Although transcriptional evidence indicates the potential presence of Th1-like cells in some fish species, the ...
Kete Ai, Kang Li, Xinying Jiao, Yu Zhang, Jiaqi Li, Qian Zhang, Xiumei Wei, Jialong Yang   +7 more
doaj   +2 more sources