Results 11 to 20 of about 198,196 (300)

IL-10-producing Th1 cells possess a distinct molecular signature in malaria. [PDF]

J Clin Invest, 2023
Control of intracellular parasites responsible for malaria requires host IFN-γ+T-bet+CD4+ T cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this inflammatory response.
Edwards CL, Ng SS, de Labastida Rivera F, Corvino D, Engel JA, Montes de Oca M, Bukali L, Frame TC, Bunn PT, Chauhan SB, Singh SS, Wang Y, Na J, Amante FH, Loughland JR, Soon MS, Waddell N, Mukhopadhay P, Koufariotis LT, Johnston RL, Lee JS, Kuns R, Zhang P, Boyle MJ, Hill GR, McCarthy JS, Kumar R, Engwerda CR.   +27 more
europepmc   +3 more sources

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells

Cells, 2017
During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell ...
Andrea Duechting, Anna Przybyla, Stefanie Kuerten, Paul V. Lehmann   +3 more
doaj   +4 more sources

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection. [PDF]

, 2015
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised.
Ed C. Lavelle (237659), Joan A. Geoghegan, O'Halloran, Dara P, Joan A. Geoghegan (7934549), Alison G Murphy, Micheál Mac Aogáin (4872235), Timothy J. Foster, O'Keeffe, Kate M, Claire H. Hearnden (552564), Jérôme P. Fennell, Deirdre Fitzgerald Hughes (7895360), Jérôme P. Fennell (822610), Ed C. Lavelle, Keenan A. Lacey (822607), Tavakol, Mehri, McLoughlin, Rachel M, Willem J van Wamel, Kate M. O’Keeffe (822605), Willem J. van Wamel (822611), Thomas R. Rogers, Timothy J Foster, Geoghegan, Joan A; id_orcid, Rogers, Thomas R, Kate M. O'Keeffe (7934531), Alison G. Murphy (339426), Brown, Aisling F, Ed C. Lavelle (6758882), Mehri Tavakol (106145), Kate M. O’Keeffe, Leech, John M, Keenan A Lacey, Rachel M. McLoughlin (109534), Claire H. Hearnden, John M. Leech (822604), Joan A. Geoghegan (109518), Foster, Timothy J, Deirdre Fitzgerald-Hughes, Fennell, Jérôme P, Keenan A. Lacey (7934537), Timothy J. Foster (47141), Hearnden, Claire H, Aisling F. Brown, Aisling F. Brown (822602), John M. Leech, Hilary Humphreys (822609), Alison G. Murphy (7934522), Hilary Humphreys (7895573), John M. Leech (7934528), Lalor, Stephen J, Stephen J. Lalor, Claire H. Hearnden (7934540), Fitzgerald-Hughes, Deirdre, Mehri Tavakol, Stephen J Lalor, Jérôme P Fennell, Deirdre Fitzgerald-Hughes (822608), Keenan A. Lacey, Aisling F. Brown (7934519), Humphreys, Hilary, Dara P. O'Halloran (7934534), Lacey, Keenan A, Aisling F Brown, Kate M O'Keeffe, John M Leech, Stephen J. Lalor (822603), Willem J. van Wamel (7934546), Joan A Geoghegan, Dara P. O’Halloran, Rachel M. McLoughlin, Stephen J. Lalor (7934525), Ed C Lavelle, Thomas R Rogers, Dara P. O’Halloran (822606), van Wamel, Willem J, Micheál Mac Aogáin, Thomas R. Rogers (215491), Alison G. Murphy, Lavelle, Ed C, Dara P O'Halloran, Jérôme P. Fennell (7934543), Murphy, Alison G, Hilary Humphreys, Willem J. van Wamel, Rachel M. McLoughlin (7633589), Claire H Hearnden, Rachel M McLoughlin, Mac Aogáin, Micheál   +86 more
core   +5 more sources

Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice. [PDF]

PLoS Pathog, 2022
Protective immune responses to Chlamydia infection within the female reproductive tract (FRT) are incompletely understood. MHC class II-restricted CD4 Th1 responses are believed to be vital for bacterial clearance due to their capacity to secrete IFN-γ ...
Rixon JA, Depew CE, McSorley SJ.
europepmc   +3 more sources

Innate acting memory Th1 cells modulate heterologous diseases. [PDF]

Proc Natl Acad Sci U S A
Through immune memory, infections have a lasting effect on the host. While memory cells enable accelerated and enhanced responses upon rechallenge with the same pathogen, their impact on susceptibility to unrelated diseases is unclear.
Rakebrandt N, Yassini N, Kolz A, Schorer M, Lambert K, Goljat E, Estrada Brull A, Rauld C, Balazs Z, Krauthammer M, Carballido JM, Peters A, Joller N.   +12 more
europepmc   +3 more sources

Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells [PDF]

, 2012
T helper17 (Th17) lymphocytes represent a third arm of the CD4+ T-cell effector responses, in addition to Th1 and Th2 cells. Th17 cells have been found to exhibit high plasticity because they rapidly shift into the Th1 phenotype in inflammatory sites. In
Rossi Maria Caterina, Maggi Laura, Mazzoni Alessio, Cimaz Rolando, Capone Manuela, Maggi Enrico, Liotta Francesco, De Palma Raffaele, Querci Valentina, Cosmi Lorenzo, Annunziato Francesco, Santarlasci Veronica, Romagnani Sergio   +12 more
core   +2 more sources

Th1 cells in cancer-associated inflammation [PDF]

, 2017
WOS: 000394539800003The immune system is not only evolved to protect the body from pathogens, but it also recognizes and eliminates cancer cells. CD4+ helper T (Th) lymphocytes are central intercessors differentiated according to the character of ...
Akbulut Dinç, Güneş, Güneş ESENDAĞLI, Ozkazanc, Didem, Esendagli, Gunes, Güneş DİNÇ AKBULUT, Didem ÖZKAZANÇ, Dinc Akbulut, Gunes, Esendağlı, Güneş   +7 more
core   +1 more source

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142

Brazilian Journal of Medical and Biological Research, 2019
The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins
Xiao Chen, Xue-ling Zhang, Guo-hua Zhang, Ying-fang Gao   +3 more
doaj   +1 more source

Th1/Th2 Balance in Young Subjects: Relationship with Cytokine Levels and Metabolic Profile

Journal of Inflammation Research, 2021
Ines Matia-Garcia,1 Eduardo Vadillo,2 Rosana Pelayo,3 José F Muñoz-Valle,4 Mariel García-Chagollán,4 Jaqueline Loaeza-Loaeza,1 Amalia Vences-Velázquez,1 Lorenzo Salgado-Goytia,1 Samuel García-Arellano,4 Isela Parra-Rojas1 1Facultad de Ciencias Químico ...
Matia-Garcia I, Vadillo E, Pelayo R, Muñoz-Valle JF, García-Chagollán M, Loaeza-Loaeza J, Vences-Velázquez A, Salgado-Goytia L, García-Arellano S, Parra-Rojas I   +9 more
doaj  

Common Features of Regulatory T Cell Specialization During Th1 Responses

Frontiers in Immunology, 2018
CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control ...
Katharina Littringer, Claudia Moresi, Nikolas Rakebrandt, Xiaobei Zhou, Xiaobei Zhou, Michelle Schorer, Tamas Dolowschiak, Florian Kirchner, Felix Rost, Christian W. Keller, Donal McHugh, Salomé LeibundGut-Landmann, Mark D. Robinson, Mark D. Robinson, Nicole Joller   +14 more
doaj   +1 more source