Results 31 to 40 of about 4,589,213 (294)

IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]

, 2014
IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M., Katherine A. Smith, Maizels, Rick M, Rick M. Maizels, Smith, Katherine A., Smith, Katherine A   +5 more
core   +1 more source

Helminth-induced Th2 cell dysfunction is distinct from exhaustion and is maintained in the absence of antigen.

PLoS Neglected Tropical Diseases, 2019
T cell-intrinsic regulation, such as anergy, adaptive tolerance and exhaustion, is central to immune regulation. In contrast to Type 1 and Type 17 settings, knowledge of the intrinsic fate and function of Th2 cells in chronic Type 2 immune responses is ...
Johanna A Knipper, Alasdair Ivens, Matthew D Taylor   +2 more
doaj   +1 more source

Chitinase and Fizz family members are a generalized feature of nematode infection with selective Upregulation of Ym1 and F10.1 by antigen-presenting cells [PDF]

, 2005
Ym1 and Fizz1 are secreted proteins that have been identified in a variety of Th2-mediated inflammatory settings. We originally found Ym1 and Fizz1 as highly expressed macrophage genes in a Brugia malayi infection model.
Coulson, P.S., Allen, J.E., Wilson, R.A., Gallagher, Iain J, Patricia S. Coulson, Judith E. Allen, Wilson, R A, P'ng Loke, Maizels, Rick M, Loke, P., Loke, P'ng, Taylor, M.D., Allen, Judith E, Nair, Meera G, Meera G. Nair, Nair, M.G., Taylor, Matthew D, Maizels, R.M., Matthew D. Taylor, Gallagher, L.J., Rick M. Maizels, Coulson, Patricia S, Iain J. Gallagher, R. A. Wilson   +23 more
core   +1 more source

The function and origin of the CD4+ T cell in the classical Hodgkin lymphoma microenvironment [PDF]

, 2012
PhDClassical Hodgkin lymphoma (CHL) is a germinal centre B cell malignancy where the bulk of the tumour comprises a non-clonal immune infiltrate enriched for CD4+ T cells.
Greaves, Paul
core   +4 more sources

The Concept of Pathogenic TH2 Cells: Collegium Internationale Allergologicum Update 2021. [PDF]

, 2021
T helper (TH) cells have evolved into distinct subsets that mediate specific immune responses to protect the host against a myriad of infectious and noninfectious challenges.
Bertschi, Nicole L., Schlapbach, Christoph, Bazzini, Cecilia   +2 more
core   +1 more source

Beyond CCR7: dendritic cell migration in type 2 inflammation

Frontiers in Immunology
Conventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues
Audrey Meloun, Audrey Meloun, Beatriz León   +2 more
doaj   +1 more source

Thymic Stromal Lymphopoietin and Cancer: Th2-Dependent and -Independent Mechanisms

Frontiers in Immunology, 2020
The thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine originally cloned from a murine thymic stromal cell line, and subsequently a human homolog was identified using database search methods.
Maria Pia Protti, Maria Pia Protti, Lucia De Monte, Lucia De Monte   +3 more
doaj   +1 more source

Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells. [PDF]

PLoS ONE, 2009
Inducible Costimulator (ICOS) is an important regulator of Th2 lymphocyte function and a potential immunotherapeutic target for allergy and asthma. A SNP in the ICOS 5' promoter in humans is associated with increased atopy and serum IgE in a founder ...
Bryan S Clay, Rebecca A Shilling, Hozefa S Bandukwala, Tamson V Moore, Judy L Cannon, Andrew A Welcher, Joel V Weinstock, Anne I Sperling   +7 more
doaj   +1 more source

Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory Disease

Frontiers in Medicine, 2017
There is an absolute requirement for Th2 cells in the pathogenesis of allergen-driven eosinophil-rich type 2 inflammation. Although Th2 cells are generally regarded as a homogeneous population, in the past decade there has been increasing evidence for a ...
Alyssa Mitson-Salazar, Calman Prussin
doaj   +1 more source

Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis

Frontiers in Immunology, 2017
Enhancer of zeste homolog 2 (Ezh2) has been shown to play a role in the differentiation of T helper (Th) 1 and 2 cells in mice studies using Ezh2-deficient T cells.
Tsung-Yun Hou, Tsung-Yun Hou, Tsung-Yun Hou, Ming-Rong Chen, Yu-Ching Chou, Po-Chieh Kan, Yi-Ta Tsai, Yi-Ta Tsai, Tai-Lung Cha, Tai-Lung Cha, Tai-Lung Cha   +10 more
doaj   +1 more source