Results 11 to 20 of about 4,912,109 (290)

Single-Cell RNA Sequencing Reveals T Helper Cells Synthesizing Steroids De Novo to Contribute to Immune Homeostasis [PDF]

Cell Reports, 2014
T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2 signaling molecules.
Bidesh Mahata, Xiuwei Zhang, Aleksandra A. Kolodziejczyk, Valentina Proserpio, Liora Haim-Vilmovsky, Angela E. Taylor, Daniel Hebenstreit, Felix A. Dingler, Victoria Moignard, Berthold Göttgens, Wiebke Arlt, Andrew N.J. McKenzie, Sarah A. Teichmann   +12 more
doaj   +2 more sources

Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
Infections by the soil-transmitted threadworm Strongyloides stercoralis affect 30–100 million people worldwide, predominantly in tropic and sub-tropic regions. Here we assessed the T helper cell phenotypes in threadworm-infected patients and experimental
Cristin N. Bock, Subash Babu, Subash Babu, Minka Breloer, Anuradha Rajamanickam, Yukhti Boothra, Marie-Luise Brunn, Anja A. Kühl, Roswitha Merle, Max Löhning, Max Löhning, Susanne Hartmann, Sebastian Rausch   +12 more
doaj   +2 more sources

The Metabolic Requirements of Th2 Cell Differentiation [PDF]

Frontiers in Immunology, 2019
Upon activation, naïve CD4+ T cells differentiate into a number of specialized T helper (Th) cell subsets. Th2 cells are central players in immunity to helminths and are implicated in mediating the inflammatory pathology associated with allergies.
Julian M. Stark, Christopher A. Tibbitt, Jonathan M. Coquet   +2 more
doaj   +3 more sources

The Primary Responses of Murine Neonatal Lymph Node CD4+ Cells are Th2-skewed and are Sufficient for the Development of Th2-biased Memory [PDF]

Clinical and Developmental Immunology, 2003
Exposure of neonatal mice to antigen often results in Th2-biased responses in later life. Examples of this Th2 tendency are (a) secondary antibody responses dominated by the Th2-associated IgG1 isotype and (b) Th2-mediated tolerance to alloantigens.
Becky Adkins, Yurong Bu, Vladimir Vincek, Patricia Guevara   +3 more
doaj   +2 more sources

Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response

Journal of Immunology Research, 2022
Th2 immune response is essential for providing protection against pathogens and orchestrating humoral immunity. However, excessive Th2 immune response leads to the pathogenesis of Th2 inflammation diseases, including asthma, allergic rhinitis, and atopic
Guo Liu, Feng Liu
doaj   +3 more sources

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells [PDF]

Cells, 2017
During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell ...
Andrea Duechting, Anna Przybyla, Stefanie Kuerten, Paul V. Lehmann   +3 more
doaj   +3 more sources

T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]

, 2012
Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F., James eAlexander, Frank Brombacher, Frank eBrombacher, Alexander, J., James Alexander   +5 more
core   +4 more sources

Eosinophils: Cells known for over 140 years with broad and new functions

Allergology International, 2021
Eosinophils are multifunctional leukocytes, being involved in the host defense against helminth infection, tissue homeostasis and repair of injured tissue.
Ami Aoki, Kiyoshi Hirahara, Masahiro Kiuchi, Toshinori Nakayama   +3 more
doaj   +1 more source

In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]

, 2002
We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M., Robert L. Coffman, André Boonstra, Richards, David F, Richards, D.F., Catherine M. Hawrylowicz, Savelkoul, H.F.J., Savelkoul, HFJ (Huub), Crain, Chad, Anne O'Garra, O' Garra, A, Coffman, R.L., O'Garra, Anne, Cua, D.J., Chad Crain, Cua, DJ, Huub F. Savelkoul, Coffman, RL, Waal-Malefyt, R., de, Cua, Daniel J, Savelkoul, Huub F, Barrat, Franck J, de Waal-Malefyt, René, de Waal-Malefyt, R, Hawrylowicz, Catherine M; id_orcid, Crain, C., Barrat, FJ, Barrat, F.J., Crain, C, Coffman, Robert L, Boonstra, P.A., Daniel J. Cua, Hawrylowicz, CM, Franck J. Barrat, David F. Richards, O'Garra, A., René de Waal-Malefyt, Richards, DF, Boonstra, Andre   +38 more
core   +1 more source

CD4CD25 Regulatory Cells Contribute to the Regulation of Colonic Th2 Granulomatous Pathology Caused by Schistosome Infection [PDF]

, 2011
Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity.
Adrian P. Mountford, Aynsley, Sarah A, Sarah A. Aynsley, Cook, Peter C, Hogg, Karen G., Karen G. Hogg, Peter C. Cook, Mark C. Coles, Cook, Peter C; id_orcid, Peter C Cook, Cook Peter C., Cook, Peter C., Aynsley, Sarah A., Mountford Adrian P., Joseph D. Turner, Gavin R Jenkins, Aynsley Sarah A., Mountford, Adrian P, Paveley, Ross A., Ross A Paveley, Ross A. Paveley, Coles, Mark C, Turner, Joseph, Karen G Hogg, Hogg Karen G., Jenkins, Gavin R., Adrian P Mountford, Turner, Joseph D, Sarah A Aynsley, Paveley Ross A., Coles Mark C., Gavin R. Jenkins, Paveley, Ross A, Jenkins, Gavin R, Mark C Coles, Coles, Mark C., Hogg, Karen G, Joseph D Turner, Jenkins Gavin R., Mountford, Adrian P., Turner Joseph D.   +40 more
core   +1 more source