Microbial antigens-loaded myeloma cells enhance Th2 cell proliferation and myeloma clonogenicity via Th2–myeloma cell interaction [PDF]
BMC Cancer, 2019 Background Myeloma cells retain B cell functions, considered to be potential antigen presenting cells, yet there is little information regarding promoting Th2 cell proliferation or the direct effects to myeloma on the Th2 cells stimulated by microbial ...
Faqing Tian +8 more
doaj +3 more sources
The Metabolic Requirements of Th2 Cell Differentiation [PDF]
Frontiers in Immunology, 2019 Upon activation, naïve CD4+ T cells differentiate into a number of specialized T helper (Th) cell subsets. Th2 cells are central players in immunity to helminths and are implicated in mediating the inflammatory pathology associated with allergies.
Julian M. Stark +2 more
doaj +3 more sources
Increased Proportion of Dual-Positive Th2–Th17 Cells Promotes a More Severe Subtype of Asthma
Canadian Respiratory Journal, 2021 Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma’s pathophysiological changes. Dual-positive Th2–Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce
Wenjin Sun +9 more
doaj +1 more source
TCR takedown in TH2 cells [PDF]
Nature Reviews Immunology, 2016 Yvonne Bordon
openaire +3 more sources
Eosinophils: Cells known for over 140 years with broad and new functions
Allergology International, 2021 Eosinophils are multifunctional leukocytes, being involved in the host defense against helminth infection, tissue homeostasis and repair of injured tissue.
Ami Aoki +3 more
doaj +1 more source
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]
, 2017 IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri +8 more
core +1 more source
Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment
Frontiers in Immunology, 2021 The function of T cells is critically dependent on their ability to generate metabolic building blocks to fulfil energy demands for proliferation and consecutive differentiation into various T helper (Th) cells.
Simon Schreiber +10 more
doaj +1 more source
Cellular networks controlling Th2 polarization in allergy and immunity [PDF]
, 2012 In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam +2 more
core +1 more source
CD11a polymorphisms regulate TH2 cell homing and TH2-related disease [PDF]
Journal of Allergy and Clinical Immunology, 2014 TH2-dependent diseases vary in severity according to genotype, but relevant gene polymorphisms remain largely unknown. The integrin CD11a is a critical determinant of allergic responses, and allelic variants of this gene might influence allergic phenotypes.We sought to determine major CD11a allelic variants in mice and human subjects and their ...
Knight, John +6 more
openaire +3 more sources
Phenotypic Analysis of Nasal CD69 CD4 Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps [PDF]
Journal of RhinologyBackground and Objectives Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease, classified into eosinophilic and non-eosinophilic subtypes. Although CD4+ tissue-resident memory T (TRM) cells play diverse roles in tissue homeostasis, their
Min-Seok Rha, Gyeongyeob Kim, Sol Lee
doaj +1 more source