Results 11 to 20 of about 160,112 (257)
Interleukin-33/ST2: A new signaling pathway in immunity and immunopathology [PDF]
Vojnosanitetski Pregled, 2012 nema
Pavlović Slađana +5 more
doaj +1 more source
Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity. [PDF]
PLoS ONE, 2013 Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear.
Tetsuya Sasaki +9 more
doaj +1 more source
Increased Proportion of Dual-Positive Th2–Th17 Cells Promotes a More Severe Subtype of Asthma
Canadian Respiratory Journal, 2021 Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma’s pathophysiological changes. Dual-positive Th2–Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce
Wenjin Sun +9 more
doaj +1 more source
Eosinophils: Cells known for over 140 years with broad and new functions
Allergology International, 2021 Eosinophils are multifunctional leukocytes, being involved in the host defense against helminth infection, tissue homeostasis and repair of injured tissue.
Ami Aoki +3 more
doaj +1 more source
Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment
Frontiers in Immunology, 2021 The function of T cells is critically dependent on their ability to generate metabolic building blocks to fulfil energy demands for proliferation and consecutive differentiation into various T helper (Th) cells.
Simon Schreiber +10 more
doaj +1 more source
Phenotypic Analysis of Nasal CD69 CD4 Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps [PDF]
Journal of RhinologyBackground and Objectives Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease, classified into eosinophilic and non-eosinophilic subtypes. Although CD4+ tissue-resident memory T (TRM) cells play diverse roles in tissue homeostasis, their
Min-Seok Rha, Gyeongyeob Kim, Sol Lee
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 Infections by the soil-transmitted threadworm Strongyloides stercoralis affect 30–100 million people worldwide, predominantly in tropic and sub-tropic regions. Here we assessed the T helper cell phenotypes in threadworm-infected patients and experimental
Cristin N. Bock +12 more
doaj +1 more source
Regulation of Th2 Cell Immunity by Dendritic Cells [PDF]
Immune Network, 2016 Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell ...
Na, Hyeongjin +2 more
openaire +2 more sources
JID Innovations, 2021 Group 2 innate lymphoid cells (ILCs) are thought to contribute to the pathogenesis of atopic dermatitis (AD). IL-4 stimulates T helper type 2 (Th2) cells and ILC2s to proliferate and produce cytokines. Dupilumab, an antibody against the IL-4 receptor, is
Yasutomo Imai +4 more
doaj +1 more source
Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells [PDF]
The Journal of Immunology, 2017 Abstract Posttranslational modifications of histones are well-established epigenetic modifications that play an important role in gene expression and regulation. These modifications are partly mediated by the Trithorax group (TrxG) complex, which regulates the induction or maintenance of gene transcription.
Atsushi Onodera +8 more
openaire +2 more sources