Results 61 to 70 of about 4,589,213 (294)

Resting respiratory tract dendritic cells preferentially stimulate T helper cell Type 2(Th2) responses and require obligatory cytokine signals for induction of Th1 immunity [PDF]

, 1998
Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity.
Venaille, T.J., Lee, P.T., Stumbles, P.A., Pimm, C.L., Proksch, S., Holt, P.G., Thomas, J.A.   +6 more
core  

TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma [PDF]

, 2013
PURPOSE: In leukemic cutaneous T-cell lymphoma (L-CTCL), malignant T cells accumulate in the blood and give rise to widespread skin inflammation. Patients have intense pruritus, increased immunoglobulin E (IgE), and decreased T-helper (TH)-1 responses ...
Kupper, Thomas S., Clark, Rachael A., Desimone, Jennifer A, Schaekel, Knut, Dowlatshahi, Mitra, Fisher, David C., Watanabe, Rei, Desimone, Jennifer A., Teague, Jessica E, Rook, Alain H., Fisher, David C, Teague, Jessica E., Guenova, Emmanuella; https://orcid.org/, Clark, Rachael A, Tawa, Marianne, Schlapbach, Christoph, Guenova, Emmanuella, Jiang, Ying, Rook, Alain H, Kupper, Thomas S   +19 more
core   +2 more sources

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.

PLoS ONE, 2011
BackgroundAlthough in vitro IL-4 directs CD4 T cells to produce T helper 2 (Th2)-cytokines, these cytokines can be induced in vivo in the absence of IL-4-signalling. Thus, mechanism(s), different from the in vitro pathway for Th2-induction, contribute to
Karine Serre, Cécile Bénézech, Guillaume Desanti, Saeeda Bobat, Kai-Michael Toellner, Roger Bird, Susan Chan, Philippe Kastner, Adam F Cunningham, Ian C M Maclennan, Elodie Mohr   +10 more
doaj   +1 more source

Autonomous Folding of Soft Matter From Living Polymers

Advanced Materials, EarlyView.
Origami structures are endowed with “living” polymer creases that grow, remodel, and stiffen in response to nutrient solutions. This post‐fabrication growth enables autonomous folding, iterative regrowth, and mechanical tuning involving origami assemblies, such as cranes, Miura‐ori tessellations, rigid and non‐rigid square‐twist patterns, establishing ...
Jiahe Huang, Tuo Zhao, Shixi Zang, Deep Malu, Huajian Ji, Glaucio H. Paulino, Yuhang Hu   +6 more
wiley   +1 more source

The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype [PDF]

, 2013
We previously demonstrated inhibition of ovalbumin (OVA)-induced allergic airway hyper-responsiveness in the mouse using ES-62, a phosphorylcholine-containing glycoprotein secreted by the filarial nematode, Acanthocheilonema viteae.
Al-Riyami, Lamyaa, Kean, Dorothy, McSharry, Charles, Rzepecka, Justyna, Siebeke, Ivonne, Harnett, Margaret, Coltherd, Jennifer, Steiger, Christina, Harnett, William   +8 more
core   +4 more sources

Cellular immunity of naïve and BCG vaccinated neonates [PDF]

, 2010
Includes abstract.Includes bibliographical references (leaves 153-187).Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa.
Watkins, Marcia Linda Vivienne
core   +1 more source

Imbalance of helper T cell type 1, helper T cell type 2 and associated cytokines in patients with systemic lupus erythematosus: A meta-analysis

Frontiers in Pharmacology, 2022
Objective: Th1 and Th2 cells and their associated cytokines function in the pathogenesis of systemic lupus erythematosus (SLE), but their exact roles are uncertain.
Shate Xiang, Jingjing Zhang, Mengge Zhang, Suhai Qian, Rongyun Wang, Yao Wang, Yingshi Xiang, Xinghong Ding   +7 more
doaj   +1 more source

An Imaging‐Guided, Patient‐Specific Guiding Aid (RWNGuide) for Safe and Reproducible Inner Ear Drug Delivery

Advanced Materials Technologies, EarlyView.
A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo, Shanshan Jiang, Yimian Luo, Adele Moatti, Farnaz Matin‐Mann   +4 more
wiley   +1 more source