Results 21 to 30 of about 18,242,260 (289)

IL-4Rα drives IL-4- and IL-13-mediated signal transduction.

, 2022
N1 immortalized human prostate fibroblasts were treated with vehicle, IL-4 (20ng/ml), or IL-13 (20 ng/m) with or without 2 hr pre-treatment with IL4Rα (IL4R) (400 ng) or IL-13Rα1 (40 ng) antibodies.
Mehrnaz Gharaee-Kermani (118877), Quentin D’Arcy (13919516), Jill A. Macoska (118895), Alisa Zhilin-Roth (13919519)   +3 more
core   +1 more source

The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma

Cells, 2023
Asthma is a chronic complex pulmonary disease characterized by airway inflammation, remodeling, and hyperresponsiveness. Vascular endothelial growth factor (VEGF) and eosinophil-derived neurotoxin (EDN) are two significant mediators involved in the ...
Maciej Tota, Julia Łacwik, Julia Laska, Łukasz Sędek, Krzysztof Gomułka   +4 more
doaj   +1 more source

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction

, 2009
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies, Holgate, Stephen T, Isabelle Kirby, Ida Karin Nordgren, Tavassoli, Ali, Davies, Donna E, Holloway, John W, Andrews, Allison-Lynn, Stephen T. Holgate, Nordgren, Ida Karin, John W. Holloway, Kirby, Isabelle, Allison-Lynn Andrews, Ali Tavassoli   +13 more
core   +1 more source

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Journal of Inflammation Research, 2022
Alin Laurentiu Tatu,1– 3,* Thomas Nadasdy,3,4 Anca Arbune,5,* Valentin Chioncel,6,* Carmen Bobeica,7 Elena Niculet,3,* Alina Viorica Iancu,7 Caterina Dumitru,8 Valentin Tudor Popa,3,9 Nicolas Kluger,10,11 Victor Gabriel Clatici,11 Claudiu
Tatu AL, Nadasdy T, Arbune A, Chioncel V, Bobeica C, Niculet E, Iancu AV, Dumitru C, Popa VT, Kluger N, Clatici VG, Vasile CI, Onisor C, Nechifor A   +13 more
doaj  

Differential Effects of Alarmins on Human and Mouse Basophils

Frontiers in Immunology, 2022
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Adriana R. Gambardella, Adriana R. Gambardella, Remo Poto, Remo Poto, Remo Poto, Remo Poto, Valentina Tirelli, John T. Schroeder, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, Fabrizio Mattei, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Giovanna Schiavoni   +17 more
doaj   +1 more source

IL-4 receptor mutations

Current Opinion in Immunology, 1999
IL-4 plays an important role in regulating immune responses. Distinct signaling pathways, including those for gene activation and cell differentiation and those for cell proliferation and protection from apoptosis, are initiated from the receptor complex for IL-4 following ligand-receptor engagement. Several advances have been made in our understanding
P Y, Pan, P, Rothman
openaire   +2 more sources

IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype [PDF]

, 2002
Background"Alternatively-activated" macrophages are found in Th2-mediated inflammatory settings such as nematode infection and allergic pulmonary inflammation.
Nair, Meera G, P'ng Loke, John Parkinson, Parkinson, John, Judith E Allen, Loke, P'ng, Blaxter, Mark, Meera G Nair, Guiliano, David, Mark Blaxter, Allen, Judith E, David Guiliano   +11 more
core   +1 more source

IL-4 in the Brain: A Cytokine To Remember [PDF]

The Journal of Immunology, 2012
Abstract IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this ...
Sachin P, Gadani, James C, Cronk, Geoffrey T, Norris, Jonathan, Kipnis   +3 more
openaire   +2 more sources

The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma

Biomolecules
Bronchial asthma is characterized by airway inflammation, airway hyperresponsiveness, and reversible airway obstruction. Eosinophils contribute to the pathogenesis of airway disease mainly by releasing eosinophil-specific granules, lipid mediators ...
Kazuyuki Nakagome, Makoto Nagata
doaj   +1 more source

Role of gene polymorphism of IL-4 and IL-17 in recurrent miscarriage, came in art cycles

Репродуктивная эндокринология, 2017
Most researchers suggest that more than 50% of pregnant women after use of assisted reproductive technologies (ART) are faced with the problem of miscarriage, especially in the first trimester.
K. P. Golovatyuk
doaj   +1 more source