Results 41 to 50 of about 2,017,899 (336)

Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

Virulence, 2019
Citrobacter rodentium infection is a murine model for pathogenic intestinal Escherichia coli infection. C. rodentium infection causes an initial decrease in mucus layer thickness, followed by an increase during clearance.
S. Sharba, N. Navabi, M. Padra, J. A. Persson, M. P. Quintana-Hayashi, J. K. Gustafsson, L. Szeponik, V. Venkatakrishnan, Å. Sjöling, S. Nilsson, M. Quiding-Järbrink, M. E. V. Johansson, S. K. Linden   +12 more
doaj   +1 more source

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

Frontiers in Immunology, 2020
Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado, Aurora Holgado, Harald Braun, Harald Braun, Kenneth Verstraete, Kenneth Verstraete, Domien Vanneste, Domien Vanneste, Nico Callewaert, Nico Callewaert, Savvas N. Savvides, Savvas N. Savvides, Inna S. Afonina, Inna S. Afonina, Rudi Beyaert, Rudi Beyaert   +15 more
doaj   +1 more source

Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression [PDF]

, 2009
The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders.
Aghabarari, A., Ghaemi, A., Gorji, A., Khaleghi Ghadiri, M., Khodaie, B., Lotfinia, A.A., Lotfinia, M., Meuth, S., Sajadian, A.   +8 more
core   +2 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity

Monaldi Archives for Chest Disease
Asthma is a heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and intensity, together with ...
Nidhi Girdhar, Karan Sharma, Satyajit Deshpande, Siddharth Sharma, Vishal Chopra, Anil Sontakke   +5 more
doaj   +1 more source

IL4-589C>T GENE POLYMORPHISM AND EXPRESSION OF INTERLEUKIN-4 IN PATIENTS WITH DEVELOPING CHRONIC TRAUMATIC OSTEOMYELITIS

Медицинская иммунология, 2018
Our aim was to study the influence of IL4-589C>T gene polymorphism on IL-4 expression in patients, living in Zabaikalsky Region with a diagnosis of chronic traumatic osteomyelitis developing after fractures of long bones of extremities.The study ...
A. M. Miromanov, O. B. Mironova, N. A. Miromanova   +2 more
doaj   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS

Медицинская иммунология, 2014
. The aim of this study was to evaluate some immunopathogenic features of autoimmune thyropathies (autoimmune thyroiditis and Graves’ disease), in terms of IL-2 and IL-4 production and expression of specific surface receptors on blood lymphocytes.
T. V. Saprina
doaj   +1 more source

Biological Therapy of Severe Asthma with Dupilumab, a Dual Receptor Antagonist of Interleukins 4 and 13

Vaccines, 2022
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are key cytokines involved in the pathophysiology of both immune-inflammatory and structural changes underlying type 2 asthma.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Giuseppe Armentaro, Cecilia Calabrese, Angela Sciacqua, Luca Gallelli, Alessandro Vatrella   +8 more
doaj   +1 more source