Results 41 to 50 of about 96,694,076 (289)

Pathogenesis of Atopic Dermatitis: Current Paradigm [PDF]

Iranian Journal of Immunology, 2019
Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized.
Masutaka Furue, Dugarmaa Ulzii, Yen Vu, Gaku Tsuji, Makiko Kido-Nakahara, Takeshi Nakahara   +5 more
doaj   +1 more source

Differential Effects of Alarmins on Human and Mouse Basophils

Frontiers in Immunology, 2022
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Adriana R. Gambardella, Adriana R. Gambardella, Remo Poto, Remo Poto, Remo Poto, Remo Poto, Valentina Tirelli, John T. Schroeder, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, Fabrizio Mattei, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Giovanna Schiavoni   +17 more
doaj   +1 more source

Association of IL-4 with pachychoroid neovasculopathy

Scientific Reports, 2022
Abstract The purpose of this study was to identify inflammatory cytokines that are associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150 normal subjects were examined for the levels of ...
Takashi Baba, Ayumi Koyama, Ryu Uotani, Hitomi Miyake, Kodai Inata, Shin-ichi Sasaki, Yumiko Shimizu, Yoshitsugu Inoue, Kaori Adachi, Eiji Nanba, Dai Miyazaki   +10 more
openaire   +3 more sources

IL-4 and IL-13 promote COL1A1 and αSMA co-expression and upregulate receptors inhibitors repress IL-4 and IL-13-mediated prostate myofibroblast phenoconversion.

, 2022
N1 prostate fibroblasts were treated with 20 ng/ml of IL-13 or IL- 4, or 4 ng/ml TGFβ1 (positive control) for 48 hr, then co-immunostained for COL1A1 (PE-cy5-conjugated Ab, red), αSMA (fluorescein-conjugated Ab, green), or counterstained with nuclear ...
Mehrnaz Gharaee-Kermani (118877), Quentin D’Arcy (13919516), Jill A. Macoska (118895), Alisa Zhilin-Roth (13919519)   +3 more
core   +1 more source

The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 101-111).Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N ...
Brombacher, Tiroyaone M H
core   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]

, 2011
We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ciara M. Finucane, Y. K. Stella Man, Danielle DiCara, Rita Jones, Ahuva Nissim, Stephen J. Mather, Taher E. I. Taher, Michele Bombardieri, Costantino Pitzalis, Yuti Chernajovsky, Sarah E. Wythe   +10 more
core  

IL-4 and IL-13 induce self expression in prostate fibroblasts.

, 2022
N1 or SFT1 prostate fibroblasts were cultured in serum-free media supplemented with vehicle or 20ng/ml IL-4, IL-13, IFN-γ, TNFα, or 4ng/ml TGF-β, for 24 hours with or without 2 hr pre-treatment with 400 ng/ml IL-4Rα or 40 ng/ml IL-13Rα1 antibody.
Mehrnaz Gharaee-Kermani (118877), Quentin D’Arcy (13919516), Jill A. Macoska (118895), Alisa Zhilin-Roth (13919519)   +3 more
core   +1 more source

Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

Virulence, 2019
Citrobacter rodentium infection is a murine model for pathogenic intestinal Escherichia coli infection. C. rodentium infection causes an initial decrease in mucus layer thickness, followed by an increase during clearance.
S. Sharba, N. Navabi, M. Padra, J. A. Persson, M. P. Quintana-Hayashi, J. K. Gustafsson, L. Szeponik, V. Venkatakrishnan, Å. Sjöling, S. Nilsson, M. Quiding-Järbrink, M. E. V. Johansson, S. K. Linden   +12 more
doaj   +1 more source