The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling [PDF]
Oncogenesis, 2017 Interleukin-4 plays a critical role in the regulation of immune responses and has been detected at high levels in the tumour microenvironment of cancer patients, where concentrations correlate with the grade of malignancy. In prostate cancer, interleukin-
A Heidenreich +65 more
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History of Interleukin-4 [PDF]
Cytokine, 2015 The history of the discovery and the development of our knowledge of IL-4 exemplifies the path of progress in biomedical science. There are unanticipated twists and turns although progress is made, sometimes quickly, other times far too slowly ...
W. Paul
semanticscholar +3 more sources
Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. [PDF]
, 1990 BALB/c mice infected with Leishmania major develop fatal, progressive disease, despite an immune response characterized by expansion of CD4+ T cells in the draining lymph nodes.
M D Sadick +5 more
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Interleukin-4 receptor alpha gene variants and allergic disease [PDF]
Respiratory Research, 2000 The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual.
Hall Ian P
doaj +3 more sources
The role of interleukin-4 and interleukin-5 Th2 cytokines in assessing severity and prognosis of acute pancreatitis [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2021 Introduction/Objective. Acute pancreatitis (AP) is a relatively common disease which in most patients has favorable course. However, in approximately 20% patients, the course of the disease is more severe with high mortality (40–50%).
Doklestić Krstina +6 more
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Measuring the level of IL-4 and IL-25 in the serum of eczema patients [PDF]
Romanian Journal of Infectious Diseases, 2023 Eczema is an inflammatory skin disease and may be the result of environmental factors, genetic factors, and immune factors. Itching, persistent scratching, skin redness, and dryness are the primary signs of the illness.
Ali Mohammed Abd AL-Ameer +1 more
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Targeting interleukin 4 and interleukin 13: a novel therapeutic approach in bullous pemphigoid
Annals of Medicine, 2023 Aim: Bullous pemphigoid (BP) is an organ-specific autoimmune bullous disease characterized by autoantibodies that target the cellular adhesion molecules BP180 and BP230.
Fangyuan Chen +4 more
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Functional Haplotypes in Interleukin 4 Gene Associated with Periodontitis. [PDF]
PLoS ONE, 2017 Chronic periodontitis (CP) is an infectious inflammatory disease that affects tooth-supporting structures and in which dental plaque bacteria, immune mechanisms and genetic predisposition play important roles.
Giovana Anovazzi +6 more
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IL-4Rα Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis. [PDF]
, 2020 Dupilumab is a fully human antibody to interleukin-4 receptor α that improves the signs and symptoms of moderate to severe atopic dermatitis (AD). To determine the effects of dupilumab on Staphylococcus aureus colonization and microbial diversity on the ...
Ardeleanu, Marius +16 more
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Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress [PDF]
, 2016 It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior. Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge ...
An, Kyungeh +4 more
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