Results 1 to 10 of about 684,537 (259)

Regulation of Interleukin 4 Production and of Interleukin 4-Producing Cells

International Archives of Allergy and Immunology, 2009
Interleukin 4 (IL-4) is a cytokine with a broad range of functions on immune cells including the stimulation of IgE synthesis by B cells. IL-4 is synthesized by freshly isolated T cells following appropriate stimulation with either lectins or antibodies against selected surface antigens.
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Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy

Clinical Science, 1999
Minimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy.
Gillespie, KM, Parnham, A, Clark, AGB, Mathieson, PW, Parry, RG   +4 more
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Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk

European Journal of Cancer, 2007
Interleukin-4 (IL-4) and interleukin-4 receptor (IL-4R) modulate inflammation and are associated with the colorectal adenoma-carcinoma progression and the metastatic capacity. IL-4 also causes a dose-dependent reduction of proliferation in colorectal cancer cells.
LANDI, STEFANO, BOTTARI F, GEMIGNANI, FEDERICA, GIOIA PATRICOLA L, GUINO E, OSORIO A, DE OCA J, CAPELLA G, CANZIAN F, MORENO V.   +9 more
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Interleukin-4 is a neutrophil activator

Journal of Allergy and Clinical Immunology, 1989
We investigated the ability of the lymphokine, interleukin-4 (IL-4), to function as a neutrophil (PMN) activator. IL-4 enhanced PMN-mediated killing of opsonized bacteria (by up to 91.6% at 3 units of IL-4; p less than 0.05). IL-4 was a weak secondary granule secretagogue and did not by itself generate a respiratory burst. However, IL-4 did increase in
H, Boey, R, Rosenbaum, J, Castracane, L, Borish   +3 more
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Rat interleukin-4 assays

Journal of Immunological Methods, 1998
The present article describes procedures to measure rat IL-4 protein. The RT-PCR technique has been successfully and widely used to measure IL-4 mRNA, but it does not determine IL-4 protein synthesis. Assays to measure rat IL-4 protein based on its biological activity were developed using the mAb OX-81, which inhibits rat IL-4 activity.
Ramírez, F., Stumbles, P.A., Puklavec, M., Mason, D.   +3 more
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Characterization of caprine interleukin-4

Veterinary Immunology and Immunopathology, 2001
Caprine interleukin-4 (IL-4) cDNA was cloned from RNA of mitogen stimulated goat peripheral blood mononuclear cells utilizing reverse transcriptase-polymerase chain reaction. The sequence of caprine IL-4 cDNA corresponds to a 535 nucleotide mRNA with 5'- and 3'-untranslated regions and a 405 nucleotide open reading frame, the first 66 nucleotides of ...
K R, Snekvik, J C, Beyer, G, Bertoni, B R, Von Beust, T V, Baszler, G H, Palmer, T F, McElwain, W P, Cheevers   +7 more
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An antiproliferative bioassay for interleukin-4

Journal of Immunological Methods, 1996
Interleukin-4 (IL-4) is currently being used for therapeutic intervention in a wide range of malignant diseases as an antitumour agent. Although bioassays have been developed that measure the proliferative capacity of IL-4, none measure the antiproliferative activity of this molecule.
L A, Page, M S, Topp, R, Thorpe, A R, Mire-Sluis   +3 more
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Interleukin-4 and breast cancer

Breast Cancer, 2000
IL-4 is a pleiotropic cytokine produced by T lymphocytes which acts on various cells of such as T and B lymphocytes, monocytes, fibroblast, endothelial cells, macrophages and some others. IL-4 was originally described as a B cell growth factor, and now known to provide potent anti-tumor activity against various tumors, including breast cancer. IL-4 can
S, Nagai, M, Toi
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Interleukin-4 and Cancer Therapy

Cancer Investigation, 1993
(1993). Interleukin-4 and Cancer Therapy. Cancer Investigation: Vol. 11, No. 4, pp. 473-486.
R K, Puri, J P, Siegel
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The interleukin-4 family of lymphokines

Current Biology, 1992
Evidence has accumulated indicating that four T-cell derived lymphokines, interleukin-4, interleukin-5, granulocyte-macrophage colony stimulating factor and interleukin-3, are closely related. The genes encoding these lymphokines are clustered within a region of 1000 kb, the proteins have a common secondary and spatial organization, and their ...
J L, Boulay, W E, Paul
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