Results 1 to 10 of about 731 (117)
European Psychiatry, 2022 Introduction GABAa-receptors proved to be the molecular targets of ethanol on immune and nervous cells, potentiating alcohol influence. ortho-Fluoro-benzonal is known to be a circular urea derivative and an artificial ligand of GABA/BD-receptor and thus
E. Markova, I. Savkin, Т. Shushpanova
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The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review
Cell Communication and Signaling, 2020 Background Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity and acts through its three main receptors. Their role in promoting tumour cell proliferation, migration, DNA synthesis has been studied in a wide range of ...
Stella Nikolaou +6 more
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Infectious Microbes & Diseases, 2021 . Pattern-recognition receptors, such as toll-like receptors (TLRs), detect a wide range of microbial products and initiate innate immune responses leading to the production of inflammatory mediators.
Yuna Zhao +7 more
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Effects of mitogens on androgen receptor-mediated transactivation [PDF]
Endocrinology, 1996 The effects of mitogens and agents affecting tyrosine phosphorylation signaling on androgen-regulated transcription were investigated. CV-1 and HeLa cells were cotransfected with an androgen receptor (AR) expression vector and an androgen-responsive chloramphenicol acetyltransferase (CAT) reporter gene driven by the mouse mammary tumor virus promoter ...
P, Reinikainen +2 more
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Have thyroid hormones an impact on ovarian cancer?
Journal of Education, Health and Sport, 2018 Thyroid hormones show not only genomic, but also nongenomic activity, which is related to specific membrane, cytoplasmic and organelle receptors. The best known receptors are located on the alpha-V-beta-3 integrin of cell membrane.
Klaudia Żak +5 more
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Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells. [PDF]
PLoS Pathogens, 2009 Recognition of conserved bacterial products by innate immune receptors leads to inflammatory responses that control pathogen spread but that can also result in pathology.
Vincent M Bruno +5 more
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Mitogenic Signaling via G Protein-Coupled Receptors [PDF]
Endocrine Reviews, 1996 I. Introduction RECEPTORS coupled to heterotrimeric GTP-binding proteins (G proteins) comprise the largest known family of cell surface receptors and mediate cellular responses to a diverse array of signaling molecules, including peptide and glycopeptide hormones, neurotransmitters, phospholipids, odorants, and photons.
van Biesen, T +3 more
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The Insulin Receptor Isoform A: A Mitogenic Proinsulin Receptor? [PDF]
Endocrinology, 2012 The existence of a precursor (“proinsuline”) for the putative hormone “insuline” was already postulated in 1916 (before the isolation of insulin) by Sir Edward Sharpey Schafer (1). It took another half-century for proinsulin to be isolated and characterized by Don Steiner (for recent review, see Ref. 2).
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Neoplasia: An International Journal for Oncology Research, 2011 Triple-negative breast cancers have a poor prognosis and are not amenable to endocrine- or HER2-targeted therapies. The prevailing view is that targeting the insulin-like growth factor (IGF) signal transduction pathway will not be beneficial for triple ...
Zoë Davison +3 more
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The functions and regulatory pathways of S100A8/A9 and its receptors in cancers
Frontiers in Pharmacology, 2023 Inflammation primarily influences the initiation, progression, and deterioration of many human diseases, and immune cells are the principal forces that modulate the balance of inflammation by generating cytokines and chemokines to maintain physiological ...
Huimin Zhou +4 more
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