Results 41 to 50 of about 830 (216)

Proliferative signaling initiated in ACTH receptors

Brazilian Journal of Medical and Biological Research, 2000
This article reviews recent results of studies aiming to elucidate modes of integrating signals initiated in ACTH receptors and FGF2 receptors, within the network system of signal transduction found in Y1 adrenocortical cells.
C.F.P. Lotfi, A.P. Lepique, F.L. Forti, T.T. Schwindt, C.B. Eichler, M.O. Santos, I.T. Rebustini, G.N.M. Hajj, L. Juliano, H.A. Armelin   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Epidermal growth factor mediates spermatogonial proliferation in newt testis

Reproductive Biology and Endocrinology, 2008
The complex processes of spermatogenesis are regulated by various factors. The aim of the current study is to determine the effect of epidermal growth factor (EGF) on spermatogonial proliferation and clarify the mechanism causing the proliferation in ...
Abé Shin-ichi, Eto Ko, Abé Keisuke
doaj   +1 more source

Functional characterization of two corticotropin-releasing hormone receptors in Larimichthys crocea

Frontiers in Marine Science, 2023
In the neuroendocrine system, corticotropin-releasing hormone (CRH) plays an important role in the hypothalamic–pituitary–adrenal/interrenal (HPA/HPI) axis. It exerts its effects by activating CRHRs, which belong to the class B G protein-coupled receptor
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Extracellular-Regulated Kinase Effector Lk6 is Required for Glutamate Receptor Localization at the Neuromuscular Junction

Journal of Experimental Neuroscience, 2016
The proper localization and synthesis of postsynaptic glutamate receptors are essential for synaptic plasticity. Synaptic translation initiation is thought to occur via the target of rapamycin (TOR) and mitogen-activated protein kinase signal-integrating
Nizar A. Hussein, Taylor L. Delaney, Brittany L. Tounsel, Faith L.W. Liebl   +3 more
doaj   +1 more source

MEK1 inhibits cardiac PPARα activity by direct interaction and prevents its nuclear localization. [PDF]

PLoS ONE, 2012
BACKGROUND: The response of the postnatal heart to growth and stress stimuli includes activation of a network of signal transduction cascades, including the stress activated protein kinases such as p38 mitogen-activated protein kinase (MAPK), c-Jun NH2 ...
Hamid el Azzouzi, Stefanos Leptidis, Meriem Bourajjaj, Marc van Bilsen, Paula A da Costa Martins, Leon J De Windt   +5 more
doaj   +1 more source

Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions

Antioxidants, 2022
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic cannabinoids have received growing interest as treatment options in neurodegenerative conditions.
Ana Tadijan, Ignacija Vlašić, Josipa Vlainić, Domagoj Đikić, Nada Oršolić, Maja Jazvinšćak Jembrek   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Immunoregulation by low density lipoproteins in man: low density lipoprotein inhibits mitogen-stimulated human lymphocyte proliferation after initial activation.

Journal of Lipid Research, 1983
Low density lipoprotein (LDL, d 1.020-1.050 g/ml), isolated from normal human plasma by ultracentrifugation, inhibited mitogen-stimulated proliferation of human lymphocytes in a concentration-dependent manner. In order to characterize the inhibition more
J A Cuthbert, P E Lipsky
doaj   +1 more source