Results 21 to 30 of about 830 (216)

Induction of Homologue of Slimb Ubiquitin Ligase Receptor by Mitogen Signaling [PDF]

Journal of Biological Chemistry, 2002
Homologue of Slimb (HOS) is the substrate-recognizing component of the SCF(HOS)-Roc1 E3 ubiquitin protein ligase. This ligase mediates ubiquitination of the inhibitor of NF-kappaB transcription factor (IkappaB). We have found that HOS is highly expressed in a number of human cancer cell lines. The rates of the HOS gene transcription as well as HOS mRNA
Vladimir S, Spiegelman, Weigang, Tang, Andrew M, Chan, Makoto, Igarashi, Stuart A, Aaronson, David A, Sassoon, Masaru, Katoh, Thomas J, Slaga, Serge Y, Fuchs   +8 more
openaire   +2 more sources

Memory Deficits Induced by Inflammation Are Regulated by α5-Subunit-Containing GABAA Receptors

Cell Reports, 2012
Systemic inflammation causes learning and memory deficits through mechanisms that remain poorly understood. Here, we studied the pathogenesis of memory loss associated with inflammation and found that we could reverse memory deficits by pharmacologically
Dian-Shi Wang, Agnieszka A. Zurek, Irene Lecker, Jieying Yu, Armen M. Abramian, Sinziana Avramescu, Paul A. Davies, Stephen J. Moss, Wei-Yang Lu, Beverley A. Orser   +9 more
doaj   +1 more source

Type 2 Diabetes Mellitus Mediation by the Disruptive Activity of Environmental Toxicants on Sex Hormone Receptors: In Silico Evaluation

Toxics, 2021
This study investigates the disruptive activity of environmental toxicants on sex hormone receptors mediating type 2 diabetes mellitus (T2DM). Toxicokinetics, gene target prediction, molecular docking, molecular dynamics, and gene network analysis were ...
Franklyn Nonso Iheagwam, Joseph Kelechi Odiba, Olawumi Toyin Iheagwam, Olubanke Olujoke Ogunlana, Shalom Nwodo Chinedu   +4 more
doaj   +1 more source

Differential regulation of the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase, synthase, and low density lipoprotein receptor genes.

Journal of Lipid Research, 1992
The ability of mitogenic stimulation of human T lymphocytes to alter the expression of genes involved in sterol metabolism was examined. Messenger RNA levels for 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, HMG-CoA synthase, and low density
JA Cuthbert, PE Lipsky
doaj   +1 more source

Phosphatases in toll-like receptors signaling: the unfairly-forgotten

Cell Communication and Signaling, 2021
Over the past 2 decades, pattern recognition receptors (PRRs) have been shown to be on the front line of many illnesses such as autoimmune, inflammatory, and neurodegenerative diseases as well as allergies and cancer.
Valérie Lannoy, Anthony Côté-Biron, Claude Asselin, Nathalie Rivard   +3 more
doaj   +1 more source

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor [PDF]

Diabetologia, 1997
Insulin has traditionally been considered as a hormone essential for metabolic regulation, while the insulin-like growth factors (IGF-I and IGF-II) are postulated to be more specifically involved in growth regulation. The conventional wisdom is that they share each other's effects only at high concentrations, due to their weak affinity for the ...
D, Ish-Shalom, C T, Christoffersen, P, Vorwerk, N, Sacerdoti-Sierra, R M, Shymko, D, Naor, P, De Meyts   +6 more
openaire   +2 more sources

Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors

BMC Neuroscience, 2011
Background Treatment of neuronal PC12 cells with ATP induces depolarisation and increases intracellular calcium levels via purinergic receptors. In many cell types, sustained elevation of intracellular calcium levels cause changes in gene expression via ...
Becker Walter, Stefos Georgios C, Prasai Prabin   +2 more
doaj   +1 more source

Biology of Pellino1: a potential therapeutic target for inflammation in diseases and cancers

Frontiers in Immunology, 2023
Pellino1 (Peli1) is a highly conserved E3 Ub ligase that exerts its biological functions by mediating target protein ubiquitination. Extensive evidence has demonstrated the crucial role of Peli1 in regulating inflammation by modulating various receptor ...
Lili Yan, Yueran Cui, Juan Feng
doaj   +1 more source

Evaluation of 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one as a p38 MAPK inhibitor in MCF-7 and MDA-MB-231 breast cancer cell lines

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Breast cancer is a diverse disease with high mortality rates, often due to metastasis. Breast cancer subtypes vary by the expression of progesterone receptor, human epidermal growth factor receptor 2, and estrogen receptor.
Mustafa Abdul Jabbar a Qader, Intesar Tarik Numan, Basma Talib Al-Sudani, Mohammed A.Abdalqader   +3 more
doaj   +1 more source

Regulation of pattern recognition receptor signaling by palmitoylation

iScience
Summary: Pattern recognition receptors (PRRs), consisting of Toll-like receptors, RIG-I-like receptors, cytosolic DNA sensors, and NOD-like receptors, sense exogenous pathogenic molecules and endogenous damage signals to maintain physiological ...
Xiaocui Li, Xiaofang Hu, Hongjuan You, Kuiyang Zheng, Renxian Tang, Fanyun Kong   +5 more
doaj   +1 more source