Results 11 to 20 of about 830 (216)
Regulation of mitogen‐activated protein kinases by glutamate receptors [PDF]
Journal of Neurochemistry, 2006 AbstractGlutamate receptors regulate gene expression in neurons by activating intracellular signaling cascades that phosphorylate transcription factors within the nucleus. The mitogen‐activated protein kinase (MAPK) cascade is one of the best characterized cascades in this regulatory process. The Ca2+‐permeable ionotropic glutamate receptor, mainly the
John Q, Wang +2 more
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An Aspartate/Insulin Receptor Chimera Mitogenically Activates Fibroblasts [PDF]
Journal of Biological Chemistry, 1996 A gene encoding the ligand-binding domain of the Escherichia coli aspartate receptor fused to the cytoplasmic domain of the insulin receptor tyrosine kinase to produce the chimeric aspartate insulin receptor (AIR) was expressed in mammalian cells. A murine fibroblast transfectant line designated CA3 was generated that stably expressed the AIR receptor.
H P, Biemann, S L, Harmer, D E, Koshland
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Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. [PDF]
PLoS Biology, 2009 G-protein-coupled receptors (GPCRs) are generally thought to signal to second messengers like cyclic AMP (cAMP) from the cell surface and to become internalized upon repeated or prolonged stimulation.
Davide Calebiro +7 more
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Journal of Pharmacological Sciences, 2010 The mechanism for sustained Ca2+ influx activated by G protein–coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a ...
Tsunaki Higa +7 more
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The role of Vitamin D in malaria
Journal of Infection in Developing Countries, 2015 An abnormal calcium-parathyroid hormone (PTH)-vitamin D axis has been reported in patients with malaria infection. A role for vitamin D in malaria has been suggested by many studies. Genetic studies have identified numerous factors that link vitamin D to
Khanh Vinh Quốc Luong +1 more
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RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. [PDF]
PLoS ONE, 2012 Recognition of virus infection by innate pattern recognition receptors (PRRs), including membrane-associated toll-like receptors (TLR) and cytoplasmic RIG-I-like receptors (RLR), activates cascades of signal transduction pathways leading to production of
Fang Guo +9 more
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Медицинская иммунология, 2015 We have analyzed clinical and laboratory data for 256 women surveyed in early pregnancy, being later classified by their pregnancy outcomes, i.e., placental insufficiency (n=106), interruption in the first trimester (n = 38) and uncomplicated cases with ...
I. A. Gazieva +2 more
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Comparative analysis of palmitoylation sites of serotonin (5‐HT) receptors in vertebrates
Neuropsychopharmacology Reports, 2018 Background In the vertebrate central nervous system as well as in the periphery, serotonin, also known as 5‐hydroxytriptamine (5‐HT), function as a neurotransmitter, a hormone or a mitogen.
Toshie Kaizuka, Takashi Hayashi
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The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
Cells, 2021 Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety of cellular functions, including cell proliferation, survival ...
Mariya Farooq +3 more
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BMC Bioinformatics, 2022 Background In cell signaling pathways, proteins interact with each other to determine cell fate in response to either cell-extrinsic (micro-environmental) or intrinsic cues.
Minsoo Kim, Eunjung Kim
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