Results 41 to 50 of about 14,230,992 (393)

Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis [PDF]

Osteoarthritis and Cartilage, 2010
IL-13/IL-4/IL-4R system has strong chondroprotective activity. We investigated polymorphisms in these genes as potential hand osteoarthritis (OA) susceptibility loci by performing a case-control association study.Eighteen common single nucleotide polymorphisms (SNPs) (nine in IL-4R, five in IL-4 and four in IL-13) were genotyped in 403 patients (380 ...
Vargiolu M., Silvestri T., BONORA, ELENA, Dolzani P., Pulsatelli L., ADDIMANDA, OLGA, Mancarella L., Punzi L., Fioravanti A., FACCHINI, ANDREA, ROMEO, GIOVANNI, MELICONI, RICCARDO   +11 more
openaire   +4 more sources

Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]

, 2020
Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core   +2 more sources

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

Immunity, 2015
SUMMARY Activation of the immune response during injury is a critical early event that determines whether the outcome of tissue restoration is regeneration or replacement of the damaged tissue with a scar.
Johanna A. Knipper, S. Willenborg, J. Brinckmann, W. Bloch, Tobias Maaß, R. Wagener, T. Krieg, T. Sutherland, A. Munitz, M. Rothenberg, A. Niehoff, R. Richardson, M. Hammerschmidt, J. Allen, S. Eming   +14 more
semanticscholar   +1 more source

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

Journal of Neuroscience, 2015
After ischemic stroke, various damage-associated molecules are released from the ischemic core and diffuse to the ischemic penumbra, activating microglia and promoting proinflammatory responses that may cause damage to the local tissue.
Xiurong Zhao, Huan Wang, Guanghua Sun, Jie Zhang, Nancy J Edwards, X. J. Aronowski   +5 more
semanticscholar   +1 more source

INTERLEUKIN 1 AND INTERLEUKIN 4 GENES POLYMORPHISM ASSOCIATED WITH EARLY AND PRESCHOOL AGE CHILDREN SENSITIZATION TO STREPTOCOCCUS PYOGENES

Инфекция и иммунитет, 2016
Background. Streptococcus pyogenes infection and sensitization to its antigens is considered to be an unfavorable factor for the induction of rheumatic pathology. The search for genetic predictors of rheumatic diseases in general, and sensitization to S.
A. V. Shabaldin, E. V. Shabaldina, S. V. Ryazantsev, A. S. Simbirtsev   +3 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Tissue Cytokine Responses in Canine Visceral Leishmaniasis [PDF]

, 2001
To elucidate the local tissue cytokine response of dogs infected with Leishmania chagasi, cytokine mRNA levels were measured in bone marrow aspirates from 27 naturally infected dogs from Brazil and were compared with those from 5 uninfected control ...
Courtenay, O., Day, M.J., Dye, C., Garcez, L.M., Kaye, P.M., Quinnell, R.J., Shaw, M.-A.   +6 more
core   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis

Frontiers in Immunology, 2017
The interleukin (IL)-4 receptor alpha (IL-4Rα), ubiquitously expressed on both innate and adaptive immune cells, controls the signaling of archetypal type 2 immune regulators; IL-4 and IL-13, which elicit their signaling action by the type 1 IL-4Rα/gamma
Ramona Hurdayal, Ramona Hurdayal, Ramona Hurdayal, Frank Brombacher, Frank Brombacher   +4 more
doaj   +1 more source

RUN and FYVE domain–containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4

Journal of Cell Biology, 2015
Interleukin-4 boosts the capacity of dendritic cells to present endogenous antigens on MHC II and to resist bacterial infection through a mechanism shown to be partially dependent on RUFY4 expression.
S. Terawaki, Voahirana Camosseto, F. Prete, T. Wenger, A. Papadopoulos, Christiane Rondeau, A. Combes, C. Rodríguez Rodrígues, Thien-Phong Vu Manh, M. Fallet, Luc English, R. Santamaría, A. R. Soares, Tobias Weil, H. Hammad, M. Desjardins, J. Gorvel, Manuel A. S. Santos, E. Gatti, P. Pierre   +19 more
semanticscholar   +1 more source