Results 11 to 20 of about 1,581,460 (288)

Interleukin-13 (IL-13) Pathway [PDF]

Science's STKE, 2005
Interleukin-13 (IL-13), like IL-4, is a cytokine produced by T H 2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils.
Ann, Kelly-Welch, Erica M, Hanson, Achsah D, Keegan   +2 more
openaire   +2 more sources

IL-13 Signaling in Liver Fibrogenesis [PDF]

Frontiers in Immunology, 2012
Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis-associated genes, e.g.
Yan eLiu, Stefan eMunker, Roman eMüllenbach, Roman eMüllenbach, Honglei eWeng   +4 more
openaire   +3 more sources

IL‐13 signaling through IL‐13 receptor α2 mediates airway epithelial wound repair [PDF]

The FASEB Journal, 2018
ABSTRACT Asthma is an airway inflammatory disease characterized by epithelial barrier dysfunction and airway remodeling. Interleukin‐13 (IL‐13) is a pleiotropic cytokine shown to contribute to features of airway remodeling.
S Jasemine, Yang, Sima, Allahverdian, Angela D R, Saunders, Emily, Liu, Delbert R, Dorscheid   +4 more
openaire   +2 more sources

Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2 [PDF]

The Journal of Experimental Medicine, 2003
Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R)α and IL-13Rα1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13Rα2, whose function in IL-13 ...
Wood, Nancy, Whitters, Matthew J., Jacobson, Bruce A., Witek, JoAnn, Sypek, Joseph P., Kasaian, Marion, Eppihimer, Michael J., Unger, Michelle, Tanaka, Takashi, Goldman, Samuel J., Collins, Mary, Donaldson, Debra D., Grusby, Michael J.   +12 more
openaire   +2 more sources

The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma

Cells, 2023
Asthma is a chronic complex pulmonary disease characterized by airway inflammation, remodeling, and hyperresponsiveness. Vascular endothelial growth factor (VEGF) and eosinophil-derived neurotoxin (EDN) are two significant mediators involved in the ...
Maciej Tota, Julia Łacwik, Julia Laska, Łukasz Sędek, Krzysztof Gomułka   +4 more
doaj   +1 more source

IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling [PDF]

, 2007
Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague ...
Bergner, Albrecht, Gamarra, Fernando, Huber, Rudolf M., Joerres, Rudolf A., Kellner, Julia, Welsch, Ulrich   +5 more
core   +1 more source

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]

, 2017
MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark, Baumjohann, Dirk, Happ, Hannah C, Locksley, Richard M, Pua, Heather H, Schneider, Christoph, Singh, Priti B, von Moltke, Jakob   +7 more
core   +2 more sources

Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study

Autoimmunity, 2022
Introduction Asthma is a chronic lung disease that injures and constricts the airways. This study evaluates the effects of agmatine on ovalbumin (OVA)-induced allergic inflammation of the airways.
Mohammed K. Еlmahdy, Rania R. Abdelaziz, Hoda S. Elmahdi, Ghada M. Suddеk   +3 more
doaj   +1 more source

Differential Effects of Alarmins on Human and Mouse Basophils

Frontiers in Immunology, 2022
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Adriana R. Gambardella, Adriana R. Gambardella, Remo Poto, Remo Poto, Remo Poto, Remo Poto, Valentina Tirelli, John T. Schroeder, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, Fabrizio Mattei, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Giovanna Schiavoni   +17 more
doaj   +1 more source

IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13 [PDF]

, 2008
Background: IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Rα1 and IL-4Rα subunits with subsequent activation of signal transducer and activator of ...
A Tomkinson, D Hebenstreit, D Kuperman, DA Kuperman, DS Faffe, DS Robinson, F Syed, G Grunig, G Grynkiewicz, GK Hershey, H Dickensheets, H Huang, H Ogata, HL Dickensheets, J Kellner, J Ohara, JA Losman, JC Laporte, K Espinosa, L Cohn, L Cohn, M Humbert, M Yoshida, MM Mentink-Kane, MO Daines, MO Daines, NM Heller, O Tliba, PE Moore, Q Chen, Q Peng, R Leigh, S Fichtner-Feigl, S Yamamoto, S Yasunaga, S Zuyderduyn, SA Shore, SJ Hirst, SO Rahaman, SP Hogan, SP Hogan, T Akimoto, T Naseer, T Sato, T Zheng, V Govindaraju, Z Huang, Z Zhu   +47 more
core   +4 more sources