Tralokinumab Effectively Disrupts the IL-13/IL-13Rα1/IL-4Rα Signaling Complex but Not the IL-13/IL-13Rα2 Complex [PDF]
JID Innovations, 2023 Tralokinumab, a fully human mAb specifically targeting the IL-13 cytokine, has demonstrated clinical efficacy and safety in patients with moderate-to-severe atopic dermatitis. Tralokinumab binds IL-13 with high affinity, which prevents the interaction of
Maxim A.X. Tollenaere +6 more
doaj +2 more sources
IL-13 Antibodies Influence IL-13 Clearance in Humans by Modulating Scavenger Activity of IL-13Rα2 [PDF]
The Journal of Immunology, 2011 Abstract Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a clinically significant impact on clearance of IL-13. We propose that Ab modulation of IL-13 interaction with IL-13Rα2 underlies this effect. Two Abs were administered to healthy subjects and mild asthmatics in
Marion T, Kasaian +6 more
openaire +4 more sources
IL-4Rα drives IL-4- and IL-13-mediated signal transduction. [PDF]
, 2022 N1 immortalized human prostate fibroblasts were treated with vehicle, IL-4 (20ng/ml), or IL-13 (20 ng/m) with or without 2 hr pre-treatment with IL4Rα (IL4R) (400 ng) or IL-13Rα1 (40 ng) antibodies.
Mehrnaz Gharaee-Kermani (118877) +3 more
core +1 more source
IL-4 and IL-13 promote COL1A1 and αSMA co-expression and upregulate receptors inhibitors repress IL-4 and IL-13-mediated prostate myofibroblast phenoconversion. [PDF]
, 2022 N1 prostate fibroblasts were treated with 20 ng/ml of IL-13 or IL- 4, or 4 ng/ml TGFβ1 (positive control) for 48 hr, then co-immunostained for COL1A1 (PE-cy5-conjugated Ab, red), αSMA (fluorescein-conjugated Ab, green), or counterstained with nuclear ...
Mehrnaz Gharaee-Kermani (118877) +3 more
core +1 more source
IL-4 and IL-13 induce expression of their cognate receptors in vitro. [PDF]
, 2022 A. N1 prostate fibroblast cells were treated with vehicle, 20 ng/ml IL-13, or 20ng/ml IL- 4, for 48 hr, fixed, permeabilized, and immunostained using mouse monoclonal IL-4Rα primary antibody detected with goat anti-mouse Alexa Fluor 594 secondary ...
Mehrnaz Gharaee-Kermani (118877) +3 more
core +1 more source
IL-4 and IL-13 induce self expression in prostate fibroblasts. [PDF]
, 2022 N1 or SFT1 prostate fibroblasts were cultured in serum-free media supplemented with vehicle or 20ng/ml IL-4, IL-13, IFN-γ, TNFα, or 4ng/ml TGF-β, for 24 hours with or without 2 hr pre-treatment with 400 ng/ml IL-4Rα or 40 ng/ml IL-13Rα1 antibody.
Mehrnaz Gharaee-Kermani (118877) +3 more
core +1 more source
IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling [PDF]
, 2007 Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague ...
Kellner, Julia +6 more
core +1 more source
Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction [PDF]
, 2009 IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies +13 more
core +1 more source
IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics [PDF]
, 2016 Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob +10 more
core +2 more sources
Respirology Case Reports, 2021 Dupilumab, a human monoclonal antibody against interleukin‐4 (IL‐4) and IL‐13, has been approved for treating severe asthma and eosinophilic chronic rhinosinusitis (ECRS).
Yoshiro Kai +6 more
doaj +1 more source