Results 11 to 20 of about 72,327,479 (284)

Tralokinumab Effectively Disrupts the IL-13/IL-13Rα1/IL-4Rα Signaling Complex but Not the IL-13/IL-13Rα2 Complex

JID Innovations, 2023
Tralokinumab, a fully human mAb specifically targeting the IL-13 cytokine, has demonstrated clinical efficacy and safety in patients with moderate-to-severe atopic dermatitis. Tralokinumab binds IL-13 with high affinity, which prevents the interaction of
Maxim A.X. Tollenaere, Christina Mølck, Ian Henderson, Scott Pollack, Philip Addis, Helle Heibroch Petersen, Hanne Norsgaard   +6 more
doaj   +2 more sources

BALB/c mice deficient in CD4(+) T cell IL-4R alpha expression control Leishmania mexicana load although female but not male mice develop a healer phenotype [PDF]

, 2011
Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated with a biased Th2 response while similarly infected IL-4R alpha-deficient mice fail to develop lesions and develop a robust ...
Owain R Millington, Bryson Karen J., Millington Owain R., McGachy, Adrienneh H., Brombacher, F, Mokgethi Thabang, Bryson, Karen, H. Adrienne McGachy, Owain R. Millington, McGachy, Adrienne, H Adrienne McGachy, James Alexander, Mokgethi, T, Karen J Bryson, Alexander, James, Brombacher Frank, Frank Brombacher, Alexander James, McGachy, Helen, Bryson, Karen J., Thabang Mokgethi, Millington, Owain R., Millington, Owain, Brombacher, Frank, Mokgethi, Thabang, Bryson, Karen J, Karen J. Bryson, McGachy, H Adrienne, McGachy H. Adrienne, Millington, Owain R   +29 more
core   +3 more sources

IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk.

, 2015
BACKGROUND: Mast cell localization within the airway smooth muscle (ASM)-bundle plays an important role in the development of airway hyper-responsiveness (AHR).
E. Gomez (6708803), R. Saunders (7579763), F. Hollins (7629950), Y. Amrani (7624199), C. E. Brightling (7605035), R. Berair (7629947), D. Kaur (7629944), A. Humbles (7629959), F. R. Rose (7629953), C. Doe (7595072), R. May (2413453), L. Woodman (7606790), J. Kearley (7629956), E. S. Cohen (7595081)   +13 more
core   +5 more sources

IL-4Rα drives IL-4- and IL-13-mediated signal transduction.

, 2022
N1 immortalized human prostate fibroblasts were treated with vehicle, IL-4 (20ng/ml), or IL-13 (20 ng/m) with or without 2 hr pre-treatment with IL4Rα (IL4R) (400 ng) or IL-13Rα1 (40 ng) antibodies.
Mehrnaz Gharaee-Kermani (118877), Quentin D’Arcy (13919516), Jill A. Macoska (118895), Alisa Zhilin-Roth (13919519)   +3 more
core   +1 more source

IL-4 and IL-13 promote COL1A1 and αSMA co-expression and upregulate receptors inhibitors repress IL-4 and IL-13-mediated prostate myofibroblast phenoconversion.

, 2022
N1 prostate fibroblasts were treated with 20 ng/ml of IL-13 or IL- 4, or 4 ng/ml TGFβ1 (positive control) for 48 hr, then co-immunostained for COL1A1 (PE-cy5-conjugated Ab, red), αSMA (fluorescein-conjugated Ab, green), or counterstained with nuclear ...
Mehrnaz Gharaee-Kermani (118877), Quentin D’Arcy (13919516), Jill A. Macoska (118895), Alisa Zhilin-Roth (13919519)   +3 more
core   +1 more source

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics [PDF]

, 2016
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob, Van Laar, Jacob M., O'Reilly, Steven, Fullard, Nicola, Ciechomska, Marzena, Przyborski, Stefan, van Laar, J.M., O’Reilly, S., Fullard, N., Przyborski, S., Ciechomska, M., Infection & Immunity, MS Reumatologie/Immunologie/Infectie   +12 more
core   +1 more source

IL-13 Signaling in Liver Fibrogenesis [PDF]

Frontiers in Immunology, 2012
Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis-associated genes, e.g.
Yan eLiu, Stefan eMunker, Roman eMüllenbach, Roman eMüllenbach, Honglei eWeng   +4 more
openaire   +3 more sources

In vitro Culture with Cytokines Provides a Tool to Assess the Effector Functions of ILC2s in Peripheral Blood in Asthma

Journal of Asthma and Allergy, 2021
Li Y Drake,1,2 Kathleen R Bartemes,1,3 Kay A Bachman,1 John B Hagan,1 Hirohito Kita1,4 1Division of Allergic Diseases and Department of Medicine, Mayo Clinic, Rochester, MN, USA; 2Department of Anesthesiology and Perioperative Medicine, Mayo Clinic ...
Drake LY, Bartemes KR, Bachman KA, Hagan JB, Kita H   +4 more
doaj  

The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma

Cells, 2023
Asthma is a chronic complex pulmonary disease characterized by airway inflammation, remodeling, and hyperresponsiveness. Vascular endothelial growth factor (VEGF) and eosinophil-derived neurotoxin (EDN) are two significant mediators involved in the ...
Maciej Tota, Julia Łacwik, Julia Laska, Łukasz Sędek, Krzysztof Gomułka   +4 more
doaj   +1 more source

Elimination of IL-13 Reverses Established Goblet Cell Metaplasia into Ciliated Epithelia in Airway Epithelial Cell Culture

Allergology International, 2006
Background: Interleukin (IL)-13 induces goblet cell metaplasia and plays an important role in mucus hypersecretion in asthma. We previously reported that IL-13 induced goblet cell differentiation along with less ciliated cell differentiation in guinea ...
Mitsuko Kondo, Jun Tamaoki, Kiyoshi Takeyama, Kazuo Isono, Kiyomi Kawatani, Takehiro Izumo, Atsushi Nagai   +6 more
doaj   +1 more source