Results 31 to 40 of about 72,327,479 (284)
IL-13 Receptor α2 Selectively Inhibits IL-13-Induced Responses in the Murine Lung [PDF]
The Journal of Immunology, 2008 Abstract IL-13 is a critical cytokine at sites of Th2 inflammation. In these locations it mediates its effects via a receptor complex, which contains IL-4Rα and IL-13Rα1. A third, high-affinity IL-13 receptor, IL-13Rα2, also exists. Although it was initially felt to be a decoy receptor, this has not been formally demonstrated and the ...
Tao, Zheng +8 more
openaire +2 more sources
Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study
Autoimmunity, 2022 Introduction Asthma is a chronic lung disease that injures and constricts the airways. This study evaluates the effects of agmatine on ovalbumin (OVA)-induced allergic inflammation of the airways.
Mohammed K. Еlmahdy +3 more
doaj +1 more source
Montelukast improves the changes of cytoskeletal and adaptor proteins of human podocytes by interleukin-13 [PDF]
, 2017 OBJECTIVE AND DESIGN: Interleukin-13 (IL-13) has recently been reported to be a potential cytokine in the pathogenesis of minimal-change nephrotic syndrome (MCNS).
Su-Bin Seong +12 more
core +1 more source
The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma
BiomoleculesBronchial asthma is characterized by airway inflammation, airway hyperresponsiveness, and reversible airway obstruction. Eosinophils contribute to the pathogenesis of airway disease mainly by releasing eosinophil-specific granules, lipid mediators ...
Kazuyuki Nakagome, Makoto Nagata
doaj +1 more source
Journal of Inflammation Research, 2022 Alin Laurentiu Tatu,1– 3,* Thomas Nadasdy,3,4 Anca Arbune,5,* Valentin Chioncel,6,* Carmen Bobeica,7 Elena Niculet,3,* Alina Viorica Iancu,7 Caterina Dumitru,8 Valentin Tudor Popa,3,9 Nicolas Kluger,10,11 Victor Gabriel Clatici,11 Claudiu
Tatu AL +13 more
doaj
Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2 [PDF]
The Journal of Experimental Medicine, 2003 Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R)α and IL-13Rα1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13Rα2, whose function in IL-13 ...
Wood, Nancy +12 more
openaire +2 more sources
Viruses, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
John Foerster, Aleksandra Molęda
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld +5 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo +9 more
wiley +1 more source
IL-4 and IL-13-polarized M2 macrophages are deficient in IL-10 and CCL17 secretion.
, 2018 (A) Differential cytokine secretion profiles of M1 macrophages and M2 macrophages exposed to IL-4 and IL-13. (B) Differential cell surface marker expression. MFI indicates mean fluorescence intensity. (C) Differential gene expression. For panels A and C,
Elizabeth M. Jaffee (183374) +5 more
core +1 more source