Results 21 to 30 of about 9,970,140 (285)
iIL13Pred: improved prediction of IL-13 inducing peptides using popular machine learning classifiers
BMC Bioinformatics, 2023 Background Inflammatory mediators play havoc in several diseases including the novel Coronavirus disease 2019 (COVID-19) and generally correlate with the severity of the disease.
Pooja Arora +4 more
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Cells, 2023 Asthma is a chronic complex pulmonary disease characterized by airway inflammation, remodeling, and hyperresponsiveness. Vascular endothelial growth factor (VEGF) and eosinophil-derived neurotoxin (EDN) are two significant mediators involved in the ...
Maciej Tota +4 more
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Allergology International, 2006 Background: Interleukin (IL)-13 induces goblet cell metaplasia and plays an important role in mucus hypersecretion in asthma. We previously reported that IL-13 induced goblet cell differentiation along with less ciliated cell differentiation in guinea ...
Mitsuko Kondo +6 more
doaj +1 more source
Differential Effects of Alarmins on Human and Mouse Basophils
Frontiers in Immunology, 2022 Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Adriana R. Gambardella +17 more
doaj +1 more source
Interleukin-13 (IL-13) Pathway [PDF]
Science's STKE, 2005 Interleukin-13 (IL-13), like IL-4, is a cytokine produced by T H 2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils.
Ann, Kelly-Welch +2 more
openaire +2 more sources
Selective IL-13 inhibitors for the treatment of atopic dermatitis
Drugs in Context, 2021 Background: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. AD pathogenesis is multifactorial, involving environmental and genetic factors.
Francisca Gonçalves +2 more
doaj +1 more source
Effects of IL-13 on murine listeriosis [PDF]
International Immunology, 1997 Acquired resistance against Listeria monocytogenes is a typical T helper (Th) 1 dominated immune response, whereas Th2 cytokines are thought to worsen listeriosis. We investigated effects of recombinant IL-13 (rIL-13) on the host response to L. monocytogenes in mice.
Flesch, I., Wandersee, A., Kaufmann, S.
openaire +3 more sources
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Frontiers in Immunology, 2020 Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado +15 more
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Pathogenesis of Atopic Dermatitis: Current Paradigm [PDF]
Iranian Journal of Immunology, 2019 Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized.
Masutaka Furue +5 more
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IL-13 Receptor α2 Selectively Inhibits IL-13-Induced Responses in the Murine Lung [PDF]
The Journal of Immunology, 2008 Abstract IL-13 is a critical cytokine at sites of Th2 inflammation. In these locations it mediates its effects via a receptor complex, which contains IL-4Rα and IL-13Rα1. A third, high-affinity IL-13 receptor, IL-13Rα2, also exists. Although it was initially felt to be a decoy receptor, this has not been formally demonstrated and the ...
Tao, Zheng +8 more
openaire +2 more sources