Results 21 to 30 of about 7,622,838 (295)

IL-13 Receptor α2 Selectively Inhibits IL-13-Induced Responses in the Murine Lung [PDF]

The Journal of Immunology, 2008
Abstract IL-13 is a critical cytokine at sites of Th2 inflammation. In these locations it mediates its effects via a receptor complex, which contains IL-4Rα and IL-13Rα1. A third, high-affinity IL-13 receptor, IL-13Rα2, also exists. Although it was initially felt to be a decoy receptor, this has not been formally demonstrated and the ...
Tao, Zheng, Wei, Liu, Sun-Young, Oh, Zhou, Zhu, Buqu, Hu, Robert J, Homer, Lauren, Cohn, Michael J, Grusby, Jack A, Elias   +8 more
openaire   +2 more sources

Impact of Anti-Diabetic Treatments on Circulating Anti-Inflammatory Mediators (IL-10 and IL-13) in Type 2 Diabetes Patients [PDF]

Journal of Bioscience and Applied Research
Background and Objectives: Type 2 diabetes mellitus (T2DM) is a chronic condition marked by persistent hyperglycemia and low-grade inflammation, involving cytokines like IL-10 and IL-13.
Muhannad Shweash, Hatem Hadeed, Mahmood Mukhlif, Mohammed Shwaish, Haitham Abd   +4 more
doaj   +1 more source

Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training

Computational and Structural Biotechnology Journal, 2023
Several anti-inflammatory cytokines have been proposed as markers for exercise monitoring in humans such as the interleukin 1 receptor agonist (IL-ra), or interleukin 13 (IL-13).
Urszula Plisak, Jarosław Szczepaniak, Magdalena Żmigrodzka, Beata Giercuszkiewicz-Hecold, Olga Witkowska-Piłaszewicz   +4 more
doaj   +1 more source

IL-4 and IL-13 increased collagen 1 gene transcription and collagen types I-V protein expression. [PDF]

, 2022
A. Total RNA purified from N1 or SFT1 prostate fibroblasts cultured in serum-free media supplemented with vehicle or 20ng/ml IL-4, IL-13, or 4ng/ml TGF-β, for 24 hours with or without 2 hr pre-treatment with 400 ng/ml IL-4Rα or 40 ng/ml IL-13Rα1 antibody
Mehrnaz Gharaee-Kermani (118877), Quentin D’Arcy (13919516), Jill A. Macoska (118895), Alisa Zhilin-Roth (13919519)   +3 more
core   +1 more source

In vitro Culture with Cytokines Provides a Tool to Assess the Effector Functions of ILC2s in Peripheral Blood in Asthma

Journal of Asthma and Allergy, 2021
Li Y Drake,1,2 Kathleen R Bartemes,1,3 Kay A Bachman,1 John B Hagan,1 Hirohito Kita1,4 1Division of Allergic Diseases and Department of Medicine, Mayo Clinic, Rochester, MN, USA; 2Department of Anesthesiology and Perioperative Medicine, Mayo Clinic ...
Drake LY, Bartemes KR, Bachman KA, Hagan JB, Kita H   +4 more
doaj  

Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2 [PDF]

The Journal of Experimental Medicine, 2003
Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R)α and IL-13Rα1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13Rα2, whose function in IL-13 ...
Wood, Nancy, Whitters, Matthew J., Jacobson, Bruce A., Witek, JoAnn, Sypek, Joseph P., Kasaian, Marion, Eppihimer, Michael J., Unger, Michelle, Tanaka, Takashi, Goldman, Samuel J., Collins, Mary, Donaldson, Debra D., Grusby, Michael J.   +12 more
openaire   +2 more sources

IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk [PDF]

, 2015
BACKGROUND: Mast cell localization within the airway smooth muscle (ASM)-bundle plays an important role in the development of airway hyper-responsiveness (AHR).
E. Gomez (6708803), F. Hollins (7629950), D. Kaur, E. Gomez, R. May, D. Kaur (7629944), C.E. Brightling, C. Doe (7595072), R. May (2413453), J. Kearley, L. Woodman, F.R. Rose, E.S. Cohen, R. Saunders (7579763), Y. Amrani (7624199), A. Humbles, C. Doe, Y. Amrani, C. E. Brightling (7605035), R. Berair (7629947), R. Saunders, A. Humbles (7629959), R. Berair, F. R. Rose (7629953), L. Woodman (7606790), J. Kearley (7629956), F. Hollins, E. S. Cohen (7595081)   +27 more
core   +1 more source

Elimination of IL-13 Reverses Established Goblet Cell Metaplasia into Ciliated Epithelia in Airway Epithelial Cell Culture

Allergology International, 2006
Background: Interleukin (IL)-13 induces goblet cell metaplasia and plays an important role in mucus hypersecretion in asthma. We previously reported that IL-13 induced goblet cell differentiation along with less ciliated cell differentiation in guinea ...
Mitsuko Kondo, Jun Tamaoki, Kiyoshi Takeyama, Kazuo Isono, Kiyomi Kawatani, Takehiro Izumo, Atsushi Nagai   +6 more
doaj   +1 more source

IL-4 and IL-13-polarized M2 macrophages are deficient in IL-10 and CCL17 secretion. [PDF]

, 2018
(A) Differential cytokine secretion profiles of M1 macrophages and M2 macrophages exposed to IL-4 and IL-13. (B) Differential cell surface marker expression. MFI indicates mean fluorescence intensity. (C) Differential gene expression. For panels A and C,
Elizabeth M. Jaffee (183374), Elias R. Gerrick (6061385), Kimberline Y. Gerrick (6061382), Anuj Gupta (4328764), Sarah J. Wheelan (200002), Srinivasan Yegnasubramanian (27577)   +5 more
core   +1 more source

iIL13Pred: improved prediction of IL-13 inducing peptides using popular machine learning classifiers

BMC Bioinformatics, 2023
Background Inflammatory mediators play havoc in several diseases including the novel Coronavirus disease 2019 (COVID-19) and generally correlate with the severity of the disease.
Pooja Arora, Neha Periwal, Yash Goyal, Vikas Sood, Baljeet Kaur   +4 more
doaj   +1 more source