Results 21 to 30 of about 1,581,460 (288)
Journal of Asthma and Allergy, 2021 Li Y Drake,1,2 Kathleen R Bartemes,1,3 Kay A Bachman,1 John B Hagan,1 Hirohito Kita1,4 1Division of Allergic Diseases and Department of Medicine, Mayo Clinic, Rochester, MN, USA; 2Department of Anesthesiology and Perioperative Medicine, Mayo Clinic ...
Drake LY +4 more
doaj
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]
, 1994 Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM +4 more
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Eosinophil-derived IL-13 promotes emphysema [PDF]
European Respiratory Journal, 2019 The inflammatory responses in chronic airway diseases leading to emphysema are not fully defined. We hypothesised that lung eosinophilia contributes to airspace enlargement in a mouse model and to emphysema in patients with chronic obstructive pulmonary disease (COPD). A transgenic mouse model of chronic type 2 pulmonary inflammation (
Alfred D. Doyle +16 more
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Allergology International, 2006 Background: Interleukin (IL)-13 induces goblet cell metaplasia and plays an important role in mucus hypersecretion in asthma. We previously reported that IL-13 induced goblet cell differentiation along with less ciliated cell differentiation in guinea ...
Mitsuko Kondo +6 more
doaj +1 more source
iIL13Pred: improved prediction of IL-13 inducing peptides using popular machine learning classifiers
BMC Bioinformatics, 2023 Background Inflammatory mediators play havoc in several diseases including the novel Coronavirus disease 2019 (COVID-19) and generally correlate with the severity of the disease.
Pooja Arora +4 more
doaj +1 more source
Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine [PDF]
, 2017 Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin
Aladegbami, Bola +6 more
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IL-13 Receptor α2 Selectively Inhibits IL-13-Induced Responses in the Murine Lung [PDF]
The Journal of Immunology, 2008 Abstract IL-13 is a critical cytokine at sites of Th2 inflammation. In these locations it mediates its effects via a receptor complex, which contains IL-4Rα and IL-13Rα1. A third, high-affinity IL-13 receptor, IL-13Rα2, also exists. Although it was initially felt to be a decoy receptor, this has not been formally demonstrated and the ...
Tao, Zheng +8 more
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The evolution of IL-4 and IL-13 and their receptor subunits [PDF]
, 2015 Peer ...
Secombes, Christopher J., Wang, Tiehui
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Computational and Structural Biotechnology Journal, 2023 Several anti-inflammatory cytokines have been proposed as markers for exercise monitoring in humans such as the interleukin 1 receptor agonist (IL-ra), or interleukin 13 (IL-13).
Urszula Plisak +4 more
doaj +1 more source
Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells [PDF]
, 2017 Type 2–associated goblet cell hyperplasia and mucus hypersecretion are well known features of asthma. 15-Lipoxygenase-1 (15LO1) is induced by the type 2 cytokine IL-13 in human airway epithelial cells (HAECs) in vitro and is increased in fresh asthmatic ...
Aldrovandi, Maceler +10 more
core +2 more sources