Results 41 to 50 of about 72,327,479 (284)

Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery

, 2023
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases.
Kayleigh Walker (6920252), Frederick W Muskett (9651299), Helena Wright (11625231), Christine Prosser (3864490), Jacqueline Kalms (1498417), Andy Merritt (4262491), Mark D Carr (9141335), Gareth Hall (7682057), Rachel Holyfield (16502058), Anthony Scott-Tucker (254508), Chitra Seewooruthun (8538480), Roberta Baravalle (8681085), Alistair Henry (2723098), Alastair DG Lawson (16555971)   +13 more
core   +4 more sources

Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain

Respiratory Research, 2002
Background Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared.
Braun Sandra, Kruse Susanne, Deichmann Klaus A   +2 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Efeito inibitório da interleucina-4 e interleucina-13 sobre a hiperalgesia inflamatória [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.O presente estudo utilizou um modelo de hiperalgesia mecânica (teste de Randall-Selitto modificado) para investigar os efeitos da interleucina(IL)-4 e IL-13 ...
Veiga, Fabiane Hiratsuka
core  

IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma [PDF]

, 2018
Diffuse intrinsic pontine glioma (DIPG) is a universally fatal childhood cancer of the brain. Despite the introduction of conventional chemotherapy and radiotherapy, improvements in survival have been marginal and long-term survivorship is uncommon. Thus,
Matthew N Svalina, Teagan P. Settelmeyer, Settelmeyer, Teagan P, Michael J Quist, Teagan P Settelmeyer, Mari Kogiso (1340682), Cynthia E. Hawkins, Noah E. Berlow (5066336), Esther Hulleman, Mari Kogiso, Lin Qi (128224), Xiao-Nan Li, Quist, Michael J, Sakir H. Gultekin (5066324), Sakir H Gultekin, Viktor Zherebitskiy, Michael J. Quist (5066330), Matthew N. Svalina (4373293), Matthew N. Svalina, Noah E Berlow, Hawkins, Cynthia E, Charles Keller (234777), Esther Hulleman (408158), Sakir H. Gultekin, Xiao-Nan Li (220248), Cynthia E. Hawkins (5066339), Lin Qi, Michael J. Quist, Yuchen Du (1722217), Yuchen Du, Cynthia E Hawkins, Viktor Zherebitskiy (5066327), Charles Keller, Noah E. Berlow, Berlow, Noah E, Gultekin, Sakir H, Teagan P. Settelmeyer (5066333), Svalina, Matthew N, Li, Xiao-Nan, Du, Yuchen, Hulleman, Esther, Keller, Charles, Kogiso, Mari, Qi, Lin, Zherebitskiy, Viktor   +44 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Association of the Expression of IL-4 and IL-13 Genes, IL-4 and IgE Serum Levels with Allergic Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2007
Immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with overexpression of Th2 cytokines such as IL-4 and IL-13.
Jalil Tavakkol Afshari, Reza Farid Hosseini, Sara Hosseini Farahabadi, Farhad Heydarian, Mohammad Hossein Boskabady, Rasoul Khoshnavaz, Alireza Razavi, Ehsan Ghayoor Karimiani, Gholamreza Ghasemi   +8 more
doaj  

Immune mechanisms of atopic dermatitis and new approaches to targeted biological therapy

Медицинский совет, 2022
This review presents current data on immunopathogenesis, the role of cytokines in inflammation in atopic dermatitis (AD). The pathogenetic phenotypes of the disease associated with various abnormalities of immune mechanisms and dysfunction of the ...
N. N. Potekaev, G. P. Tereshchenko, R. A. Khanferyan, A. L. Savastenko   +3 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source