Results 51 to 60 of about 7,622,838 (295)

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source

Regulation of IL-13 Receptors in Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 2007
Abbreviations: KC, human primary keratinocyte; STAT, signal transducer and activator of transcription; TGF, transforming growth ...
Purwar, Rahul, Werfel, Thomas, Wittmann, Miriam   +2 more
openaire   +2 more sources

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma [PDF]

, 2018
Diffuse intrinsic pontine glioma (DIPG) is a universally fatal childhood cancer of the brain. Despite the introduction of conventional chemotherapy and radiotherapy, improvements in survival have been marginal and long-term survivorship is uncommon. Thus,
Matthew N Svalina, Teagan P. Settelmeyer, Quist, Michael J., Settelmeyer, Teagan P, Michael J Quist, Teagan P Settelmeyer, Mari Kogiso (1340682), Cynthia E. Hawkins, Noah E. Berlow (5066336), Esther Hulleman, Mari Kogiso, Lin Qi (128224), Xiao-Nan Li, Quist, Michael J, Zherebitskiy, Viktor, Berlow, Noah E., Sakir H. Gultekin (5066324), Sakir H Gultekin, Settelmeyer, Teagan P., Svalina, Matthew N., Viktor Zherebitskiy, Keller, Charles, Michael J. Quist (5066330), Matthew N. Svalina (4373293), Hulleman, Esther, Li, Xiao-Nan, Matthew N. Svalina, Noah E Berlow, Qi, Lin, Gultekin, Sakir H., Hawkins, Cynthia E, Charles Keller (234777), Esther Hulleman (408158), Sakir H. Gultekin, Xiao-Nan Li (220248), Cynthia E. Hawkins (5066339), Kogiso, Mari, Hawkins, Cynthia E., Lin Qi, Michael J. Quist, Yuchen Du (1722217), Yuchen Du, Cynthia E Hawkins, Viktor Zherebitskiy (5066327), Charles Keller, Noah E. Berlow, Berlow, Noah E, Gultekin, Sakir H, Teagan P. Settelmeyer (5066333), du, Yuchen, Svalina, Matthew N   +50 more
core   +1 more source

DataSheet_1_Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery.pdf [PDF]

, 2023
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases.
Kayleigh Walker (6920252), Helena Wright (11625231), Frederick W. Muskett (7596773), Christine Prosser (3864490), Jacqueline Kalms (1498417), Andy Merritt (4262491), Gareth Hall (7682057), Mark D. Carr (7596779), Rachel Holyfield (16502058), Anthony Scott-Tucker (254508), Chitra Seewooruthun (8538480), Roberta Baravalle (8681085), Alastair D. G. Lawson (9267218), Alistair Henry (2723098)   +13 more
core   +1 more source

Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis

Viruses, 2020
Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
John Foerster, Aleksandra Molęda
doaj   +1 more source

Immune mechanisms of atopic dermatitis and new approaches to targeted biological therapy

Медицинский совет, 2022
This review presents current data on immunopathogenesis, the role of cytokines in inflammation in atopic dermatitis (AD). The pathogenetic phenotypes of the disease associated with various abnormalities of immune mechanisms and dysfunction of the ...
N. N. Potekaev, G. P. Tereshchenko, R. A. Khanferyan, A. L. Savastenko   +3 more
doaj   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Efeito inibitório da interleucina-4 e interleucina-13 sobre a hiperalgesia inflamatória [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.O presente estudo utilizou um modelo de hiperalgesia mecânica (teste de Randall-Selitto modificado) para investigar os efeitos da interleucina(IL)-4 e IL-13 ...
Veiga, Fabiane Hiratsuka
core  

IL-6 and IL-13 secretion by mast cells based on treatment. [PDF]

, 2018
Raw cytokine production for IL-6 (a) and IL-13 (c) normalized as secretion per 106 cells. (b) IL-6 production in resting (no IgE-crosslink) BMMCs only (emphasis from 2a above).
Nicholas A. Pullen (5983337), Michele R. Plewes (5983334), David O. Lyons (310105)   +2 more
core   +1 more source