Results 61 to 70 of about 7,622,838 (295)

IL-13/IL-13 Receptor Interaction, an Emerging Therapeutic Target in Allergic Disease

Allergology International, 2005
ABSTRACTInterleukin (IL)-13 is a Th-2 cytokine, known to be involved in allergic diseases. Although IL-13 and another Th- 2 cytokine, IL-4, share receptors and signal pathways, having similar biological properties, the critical role of IL- 13 alone in vivo in the pathogenesis of bronchial asthma has recently been recognized, based mainly on analyses of
Arima, Kazuhiko, Izuhara, Kenji
openaire   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

Association of the Expression of IL-4 and IL-13 Genes, IL-4 and IgE Serum Levels with Allergic Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2007
Immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with overexpression of Th2 cytokines such as IL-4 and IL-13.
Jalil Tavakkol Afshari, Reza Farid Hosseini, Sara Hosseini Farahabadi, Farhad Heydarian, Mohammad Hossein Boskabady, Rasoul Khoshnavaz, Alireza Razavi, Ehsan Ghayoor Karimiani, Gholamreza Ghasemi   +8 more
doaj  

The Sera levels of Interleukin-13 in Patients with Atopic Dermatitis in Thi-Qar province

مجلة علوم ذي قار, 2022
The Interleukin-13 (IL-13) is a component of the innate immune system that is primarily produced by Th2 cells and is found in high concentrations in skin lesions of atopic dermatitis.
Amel A. Naji, Hind M Mousa
doaj   +1 more source

Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain

Respiratory Research, 2002
Background Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared.
Braun Sandra, Kruse Susanne, Deichmann Klaus A   +2 more
doaj   +1 more source

Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets

Frontiers in Pharmacology, 2022
Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia, Enrico Heffler, Enrico Heffler, Claudia Crimi, Angelantonio Maglio, Alessandro Vatrella, Girolamo Pelaia, Giorgio Walter Canonica, Giorgio Walter Canonica   +8 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Pro-inflammatory and counter-regulatory modulators of interleukin-5–driven eosinophil programs: a framework for precision medicine in eosinophilic diseases

Frontiers in Immunology
Interleukin-5 (IL-5) is central to eosinophil differentiation, survival, and activation. Subsequent studies confirmed IL-5 receptor expression and mapped downstream signaling, showing that IL-5 promotes not only survival but also trafficking and effector
Hisashi Sasaki, Jun Miyata, Jun Miyata, Koichi Fukunaga, Koichi Fukunaga   +4 more
doaj   +1 more source

Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

Pharmaceutical Biology, 2021
Context Sargassum horneri (Turner) C. Agardh (Sargassaceae) is a brown marine alga used in oriental medicine to treat allergic conditions. Objective This study clarifies the effect of polyphenol-containing S.
Kalahe Hewage Iresha Nadeeka Madushani Herath, Jinhee Cho, Hyo Jin Kim, Duong Thi Thuy Dinh, Hyun-Soo Kim, Ginnae Ahn, You-Jin Jeon, Youngheun Jee   +7 more
doaj   +1 more source

IL-13–Mediated Regulation of Learning and Memory [PDF]

The Journal of Immunology, 2017
Abstract The role of proinflammatory cytokines in cognitive function has been investigated with both beneficial and possible detrimental effects, depending on the cytokine. More recently, the type 2 IL-4 has been demonstrated to play a role in cognition. In this study, using the Morris water maze task, we demonstrate that IL-13–deficient
Tiroyaone Masego H Bogale, Justin K Nono, Keisha S De Gouveia, Nokuthula Makena, Matthew Darby, Jacqueline Womersley, Ousman Tamgue, Frank Brombacher   +7 more
openaire   +2 more sources