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IL-33 and IL-33 Receptors in Host Defense and Diseases
Allergology International, 2010 Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated immune responses such as host defense against nematodes and allergic diseases by inducing production of such Th2-type cytokines as IL-5 and IL-13 by Th2 cells, mast cells ...
Oboki, Keisuke +4 more
openaire +2 more sources
Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis [PDF]
Pathogens and Disease, 2016 Inhalation of the fungus Cryptococcus neoformans (C. neoformans) results in pulmonary cryptococcosis associated with IL-33-dependent type 2 immunity. Lung epithelium represents the initial contact site of infection. The role of IL-33 in type 2 immunity has been analyzed, but the source of this cytokine and its effect on lung epithelial cell function in
Laura, Heyen +6 more
openaire +2 more sources
IL-33 biology in cancer: An update and future perspectives. [PDF]
, 2022 Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is constitutively expressed in the nucleus of epithelial, endothelial and fibroblast-like cells.
Vu, Vivian P +5 more
core +2 more sources
Serum IL-33 level and IL-33 gene polymorphisms in Behçet’s disease
Rheumatology International, 2014 Behçet's disease (BD) is a chronic inflammatory disease. Increased productions of cytokines including interleukin (IL)-1β and IL-18 are documented, and IL-1α and β gene polymorphisms are associated with susceptibility to the disease. IL-33 is a recently discovered member of IL-1 cytokine family.
Koca S.S. +6 more
openaire +2 more sources
IL-33-Induced Cytokine Secretion and Survival of Mouse Eosinophils Is Promoted by Autocrine GM-CSF. [PDF]
, 2016 Eosinophils are major effector cells during allergic responses and helminth infections. Recent studies further highlight eosinophils as important players in many other biological processes.
David Voehringer (713702) +5 more
core +2 more sources
The association between airway eosinophilic inflammation and IL-33 in stable non-atopic COPD
Respiratory Research, 2018 Background Interleukin(IL)-33 is an epithelial alarmin important for eosinophil maturation, activation and survival. The aim of this study was to examine the association between IL-33, its receptor expression and airway eosinophilic inflammation in non ...
Damian Tworek +8 more
doaj +1 more source
, 2022 The alarmin cytokine interleukin (IL)-33 plays an important proinflammatory role in type 2 immunity and can act on type 2 innate lymphoid cells (ILC2s) and type 2 T helper (TH2) cells in eosinophilic inflammation and asthma.
Julie Weidner (3994631) +5 more
core +1 more source
IL-33 Signaling in Lung Injury [PDF]
Translational Perioperative and Pain Medicine, 2016 Interleukin (IL)-33, a member of the IL-1 cytokine super-family, acts as both a traditional cytokine and an intracellular nuclear factor. It is generally released from damaged immune cells and signals through its receptor ST2 in an autocrine and paracrine fashion, plays important roles in type-2 innate immunity, and functions as an "alarmin" or a ...
Jing, Chang +3 more
openaire +2 more sources
Structural Basis of IL-1 Family Cytokine Signaling
Frontiers in Immunology, 2019 Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
James K. Fields +6 more
doaj +1 more source