Results 11 to 20 of about 4,627,366 (384)
IL-33 in Rheumatic Diseases [PDF]
Frontiers in Medicine, 2021 Interleukin-33 (IL-33) is a nuclear factor mainly expressed in barrier epithelium, endothelial cells, and fibroblast reticular cells. Some inflammatory cells also express IL-33 under certain conditions.
Yuanji Dong, Jixin Zhong, Lingli Dong
doaj +3 more sources
IL-33 in Mental Disorders [PDF]
Medicina, 2021 Mental disorders are common in the general population; every year about 25% of the total European population is affected by a mental condition. The prevalence of psychiatric disorders might be underestimated.
Gianluca Pandolfo +6 more
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Blockade of IL‐33 signalling attenuates osteoarthritis [PDF]
Clinical & Translational Immunology, 2020 Objectives Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage degradation, synovitis and pain. Disease modifying treatments for OA are not available.
Zengliang He +7 more
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Immunity, 2009 The interleukin-1 (IL-1)-like cytokine IL-33 is widely assumed to undergo proteolytic maturation by caspase-1. In this issue of Immunity, Lüthi et al. (2009) show that IL-33 is not a caspase-1 substrate. IL-33 is inactivated by caspase-3 and -7 to prevent an inappropriate immune response during apoptosis, but not in necrosis.
Lamkanfi, Mohamed, Dixit, Vishva M.
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IL-33 and Airway Inflammation [PDF]
Allergy, Asthma and Immunology Research, 2011 Interleukin-33 (IL-33) is the 11th member of IL-1 cytokine family which includes IL-1 and IL-18. Unlike IL-1β and IL-18, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage and may not enhance acquired immune responses through activation of inflammasome.
Oboki, Keisuke +3 more
openaire +2 more sources
Science immunology, 2022 Long-term senescent cells exhibit a secretome termed the senescence-associated secretory phenotype (SASP). Although the mechanisms of SASP factor induction have been intensively studied, the release mechanism and how SASP factors influence tumorigenesis ...
Ryota Yamagishi +28 more
semanticscholar +1 more source
TSLP, IL-33, and IL-25: not just for allergy and helminth infection.
Journal of Allergy and Clinical Immunology, 2022 The release of cytokines from epithelial and stromal cells is critical for the initiation and maintenance of tissue immunity. Three such cytokines, TSLP, IL-33, and IL-25, are important regulators of type 2 immune responses triggered by parasitic worms ...
Alison G. Stanbery +4 more
semanticscholar +1 more source
Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response
Frontiers in Immunology, 2022 The exposure of the airway epithelium to external stimuli such as allergens, microbes, and air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal lymphopoietin (TSLP). IL-25, IL-33 and TSLP interact with their ligands,
Marc Duchesne, Isobel Okoye, Paige Lacy
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Immunity, 2021 Alternatively activated macrophages (AAMs) contribute to the resolution of inflammation and tissue repair. However, molecular pathways that govern their differentiation have remained incompletely understood.
Maria Faas +25 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance IL-33R mediates local inflammatory responses and plays crucial roles in the pathogenesis of immune diseases. In this study, we identified USP38, which negatively regulates IL-33-triggered signaling by mediating K27-linked deubiquitination of
Xue-Mei Yi +4 more
semanticscholar +1 more source