Results 11 to 20 of about 3,545,338 (242)

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis

Cell Death and Disease, 2023
Endometriosis is a gynecological inflammatory disease that is linked with immune cells, specifically macrophages. IL-33 secreted from macrophages is known to accelerate the progression of endometriosis.
Qiong Wu, Zongwen Liang, Jing Jiang, Xiaoming Feng, Jinming Liu, Zongfeng Zhang, Hongli Wang, Ning Wang, Yanling Gou, Zhi Li, Yingying Cao   +10 more
semanticscholar   +1 more source

SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape

Science Signaling, 2023
Interleukin-33 (IL-33) functions both as a secreted cytokine and as a nuclear factor, with pleiotropic roles in cancer and immunity. Here, we explored its role in hepatocellular carcinoma (HCC) and identified that a posttranslational modification altered
Zengbin Wang, B. Pan, Jiacheng Qiu, Xiaoxia Zhang, Xiaoling Ke, Shuling Shen, Xiaoxuan Wu, Yuxin Yao, N. Tang   +8 more
semanticscholar   +1 more source

IL-33 and Airway Inflammation [PDF]

Allergy, Asthma and Immunology Research, 2011
Interleukin-33 (IL-33) is the 11th member of IL-1 cytokine family which includes IL-1 and IL-18. Unlike IL-1β and IL-18, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage and may not enhance acquired immune responses through activation of inflammasome.
Oboki, Keisuke, Nakae, Susumu, Matsumoto, Kenji, Saito, Hirohisa   +3 more
openaire   +2 more sources

Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma

Science immunology, 2022
Long-term senescent cells exhibit a secretome termed the senescence-associated secretory phenotype (SASP). Although the mechanisms of SASP factor induction have been intensively studied, the release mechanism and how SASP factors influence tumorigenesis ...
Ryota Yamagishi, Fumitaka Kamachi, Masaru Nakamura, S. Yamazaki, Tomonori Kamiya, M. Takasugi, Yi Cheng, Yoshiki Nonaka, Yoshimi Yukawa‐Muto, L. Thuy, Yohsuke Harada, T. Arai, Tze Mun Loo, S. Yoshimoto, T. Ando, M. Nakajima, H. Taguchi, Takamasa Ishikawa, H. Akiba, S. Miyake, M. Kubo, Y. Iwakura, Shinji Fukuda, Wei‐Yu Chen, N. Kawada, A. Rudensky, S. Nakae, Eiji Hara, Naoko Ohtani   +28 more
semanticscholar   +1 more source

IL-33 Raises Alarm [PDF]

Immunity, 2009
The interleukin-1 (IL-1)-like cytokine IL-33 is widely assumed to undergo proteolytic maturation by caspase-1. In this issue of Immunity, Lüthi et al. (2009) show that IL-33 is not a caspase-1 substrate. IL-33 is inactivated by caspase-3 and -7 to prevent an inappropriate immune response during apoptosis, but not in necrosis.
Lamkanfi, Mohamed, Dixit, Vishva M.
openaire   +2 more sources

Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex

European Respiratory Journal, 2023
Extract The airway epithelium plays a central role in the initiation and development of chronic airway diseases [1]. It is the first line of defence against the external environment; therefore, numerous inflammatory and tissue remodelling pathways exist ...
Sam Strickson, Kirsty F. Houslay, V. A. Negri, Y. Ohne, T. Ottosson, R. Dodd, C. Huntington, Tina Baker, Jingjing Li, K. Stephenson, A. O'Connor, J. S. Sagawe, H. Killick, Tom Moore, D. G. Rees, Sofia Koch, C. Sanden, Yixin Wang, Elise Gubbins, M. Ghaedi, R. Kolbeck, Saumyaa Saumyaa, J. Erjefält, G. Sims, A. Humbles, I. Scott, X. Romero Ros, E. S. Cohen   +27 more
semanticscholar   +1 more source

SERUM LEVEL OF IL-33 IN GOUTY RENAL PATIENTS [PDF]

Ain Shams Medical Journal, 2021
Background: Gout is a form of inflammatory arthritis and the most common metabolic disease in humans. It may result in tophi, kidney stones, or even kidney damage.
Afaf Mostafa, Marwa El Najjar, Mariam Abd El Monaem, Randa Mabrouk   +3 more
doaj   +1 more source

Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response

Frontiers in Immunology, 2022
The exposure of the airway epithelium to external stimuli such as allergens, microbes, and air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal lymphopoietin (TSLP). IL-25, IL-33 and TSLP interact with their ligands,
Marc Duchesne, Isobel Okoye, Paige Lacy
doaj   +1 more source

TSLP, IL-33, and IL-25: not just for allergy and helminth infection

Journal of Allergy and Clinical Immunology, 2022
The release of cytokines from epithelial and stromal cells is critical for the initiation and maintenance of tissue immunity. Three such cytokines, TSLP, IL-33, and IL-25, are important regulators of type 2 immune responses triggered by parasitic worms ...
Alison G. Stanbery, S. Smita, Jakob von Moltke, Elia D. Tait Wojno, S. Ziegler   +4 more
semanticscholar   +1 more source

A dysregulated sebum–microbial metabolite–IL-33 axis initiates skin inflammation in atopic dermatitis

Journal of Experimental Medicine, 2022
This study demonstrates that a dysregulated sebum–microbial metabolite–IL-33 axis is involved in the pathogenesis of atopic dermatitis, possibly by playing an initiating role in the induction of skin inflammation.
Z. Qiu, Zhenlai Zhu, Xiaochun Liu, Baichao Chen, H. Yin, Chaoying Gu, Xiaokai Fang, Ronghui Zhu, Tianze Yu, Wenli Mi, Hong Zhou, Yufeng Zhou, X. Yao, Wei Li   +13 more
semanticscholar   +1 more source