Results 31 to 40 of about 7,408,636 (290)

Altered expression of IL-18, IL-18 binding protein and IL-18 receptor in blood monocytes of patients with allergic rhinitis [PDF]

, 2020
Abstract Background: Interleukin (IL)-18 is emerging as an attractive participant in allergic rhinitis (AR). However, correlation of IL-18 with IL-18 binding protein (BP) in plasma, and expression of IL-18, IL-18BP and IL-18 receptor (R) in AR blood monocytes remain obscure.Methods: We investigated IL-18, IL-18BP and IL-18R expression in ...
Junling Wang, Fangqiu Gu, Zhi Li, Mengmeng Zhan, Ling Wang, Huiyun Zhang, Dong Chen, Hua Xie, Ruonan Chai, Nan Zhao, Ruiming Yang, Yalin Hu, Shaoheng He   +12 more
openaire   +3 more sources

Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor [PDF]

Proceedings of the National Academy of Sciences, 2006
Pancreatic islets contain cells that produce IL-18 and cells that express IL-18 receptors. In experimentally induced diabetes, islet failure correlates with IL-18 levels and diabetes is delayed with blockade of endogenous IL-18.
Eli C, Lewis, Charles A, Dinarello
openaire   +2 more sources

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

Cell Reports, 2017
SUMMARY The effects of transgenically encoded human and mouse IL-18 on T cell proliferation and its application in boosting chimeric antigen receptor (CAR) T cells are presented.
Biliang Hu, Jiangtao Ren, Yanping Luo, B. Keith, Regina M. Young, J. Scholler, Yangbing Zhao, C. June   +7 more
semanticscholar   +1 more source

IL-6 and IL-18 cytokine traps in COVID-19

Инфекция и иммунитет
Cytokines are mediators of immunity that regulate inflammation. Intensity of inflammatory process is strongly dependent on the cytokine type and duration of its effect.
A. A. Korotaeva, Elena V. Samoilova, D. A. Chepurnova, N. V. Pogosova, D. T. Kuchiev, F. N. Paleev   +5 more
doaj   +1 more source

Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation

Pulmonary Circulation, 2022
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arterial pressure, inflammation, and neointimal remodeling of pulmonary arterioles.
Emmanouil Mavrogiannis, Quint A. J. Hagdorn, Venetia Bazioti, Johannes M. Douwes, Diederik E. Van Der Feen, Silke U. Oberdorf‐Maass, Marit Westerterp, Rolf M. F. Berger   +7 more
doaj   +1 more source

UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1β Antibody

Frontiers in Immunology, 2022
NLRP1 (NACHT and leucine-rich repeat-containing protein family, pyrin domain-containing protein 1) is an innate immune sensor that is involved in the formation of inflammasome complexes.
Yuya Murase, Takuya Takeichi, Jun Koseki, Yuki Miyasaka, Yoshinao Muro, Tamio Ohno, Teppei Shimamura, Masashi Akiyama   +7 more
doaj   +1 more source

An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation

Frontiers in Immunology
IntroductionInterleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MAS ...
Liqiong Jiang, Lars P. Lunding, Lars P. Lunding, William S. Webber, Karsten Beckmann, Tania Azam, Jesper Falkesgaard Højen, Jesper Falkesgaard Højen, Jesus Amo-Aparicio, Alberto Dinarello, Tom T. Nguyen, Ulrich Pessara, Ulrich Pessara, Daniel Parera, Daniel Parera, David J. Orlicky, Stephan Fischer, Stephan Fischer, Michael Wegmann, Michael Wegmann, Charles A. Dinarello, Suzhao Li   +21 more
doaj   +1 more source

Foxp3-Positive Regulatory T Cells Contribute to Antifibrotic Effects in Renal Fibrosis via an Interleukin-18 Receptor Signaling Pathway

Frontiers in Medicine, 2020
Renal interstitial fibrosis is a common lesion in the process of various progressive renal diseases. Interleukin (IL)-18 is a proinflammatory cytokine that plays an important role in the induction of Th1 responses and is associated with renal ...
Yasuaki Hirooka, Yuji Nozaki, Kaoru Niki, Asuka Inoue, Masafumi Sugiyama, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura   +7 more
doaj   +1 more source

CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors.

Cell Reports, 2017
Adoptive therapy with chimeric antigen receptor (CAR)-redirected T cells has achieved remarkable efficacy in the treatment of hematopoietic malignancies. However, eradicating large solid tumors in advanced stages of the disease remains challenging.
M. Chmielewski, H. Abken
semanticscholar   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source