Results 31 to 40 of about 70,619,624 (286)

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells [PDF]

, 2012
Background: Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex.
Anderson, G., Anderson George, Ojala, J.O., Sutinen, E.M., Pirttilä Tuula, Antero Salminen, Salminen Antero, Johanna O Ojala, Salminen, A., Elina M Sutinen, George Anderson, Tuula Pirttilä, Pirttilä, T., Sutinen Elina M, Ojala Johanna O   +14 more
core   +2 more sources

Interleukin-18 and IL-18 Binding Protein [PDF]

, 2013
Interleukin-18 (IL 18) is a member of the IL 1 family of cytokines. Increasing reports have expanded the role of IL 18 in mediating inflammation in animal models of disease using IL 18 deficient mice, neutralization of IL 18 or deficiency in the IL 18 ...
SooHun eKim, Gilles eKaplanski, Daniela eNovick, Charles eDinarello, Charles A. Dinarello, Dinarello, C.A., Kaplanski, G., Novick, D., Soohyun Kim, Gilles Kaplanski, Kim, S., Daniela Novick   +11 more
core   +3 more sources

Increased Serum Levels of Growth-Differentiation Factor 3 (GDF3) and Inflammasome-Related Markers in Pregnant Women during Acute Zika Virus Infection

Viruses, 2022
The systemic inflammatory response elicited by acute Zika virus (ZIKV) infection during pregnancy plays a key role in the clinical outcomes in mothers and congenitally infected offspring.
Carlos Eduardo de Castro Alves, Sabrina Araújo de Melo, Jean de Melo Silva, Leonardo Calheiros de Oliveira, Valdinete Alves do Nascimento, João Hugo Abdalla Santos, Felipe Gomes Naveca, Gemilson Soares Pontes   +7 more
doaj   +1 more source

Altered expression of IL-18, IL-18 binding protein and IL-18 receptor in blood monocytes of patients with allergic rhinitis [PDF]

, 2020
Abstract Background: Interleukin (IL)-18 is emerging as an attractive participant in allergic rhinitis (AR). However, correlation of IL-18 with IL-18 binding protein (BP) in plasma, and expression of IL-18, IL-18BP and IL-18 receptor (R) in AR blood monocytes remain obscure.Methods: We investigated IL-18, IL-18BP and IL-18R expression in ...
Junling Wang, Fangqiu Gu, Zhi Li, Mengmeng Zhan, Ling Wang, Huiyun Zhang, Dong Chen, Hua Xie, Ruonan Chai, Nan Zhao, Ruiming Yang, Yalin Hu, Shaoheng He   +12 more
openaire   +3 more sources

Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor [PDF]

Proceedings of the National Academy of Sciences, 2006
Pancreatic islets contain cells that produce IL-18 and cells that express IL-18 receptors. In experimentally induced diabetes, islet failure correlates with IL-18 levels and diabetes is delayed with blockade of endogenous IL-18.
Eli C, Lewis, Charles A, Dinarello
openaire   +2 more sources

IL-6 and IL-18 cytokine traps in COVID-19

Инфекция и иммунитет
Cytokines are mediators of immunity that regulate inflammation. Intensity of inflammatory process is strongly dependent on the cytokine type and duration of its effect.
A. A. Korotaeva, Elena V. Samoilova, D. A. Chepurnova, N. V. Pogosova, D. T. Kuchiev, F. N. Paleev   +5 more
doaj   +1 more source

Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation

Pulmonary Circulation, 2022
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arterial pressure, inflammation, and neointimal remodeling of pulmonary arterioles.
Emmanouil Mavrogiannis, Quint A. J. Hagdorn, Venetia Bazioti, Johannes M. Douwes, Diederik E. Van Der Feen, Silke U. Oberdorf‐Maass, Marit Westerterp, Rolf M. F. Berger   +7 more
doaj   +1 more source

UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1β Antibody

Frontiers in Immunology, 2022
NLRP1 (NACHT and leucine-rich repeat-containing protein family, pyrin domain-containing protein 1) is an innate immune sensor that is involved in the formation of inflammasome complexes.
Yuya Murase, Takuya Takeichi, Jun Koseki, Yuki Miyasaka, Yoshinao Muro, Tamio Ohno, Teppei Shimamura, Masashi Akiyama   +7 more
doaj   +1 more source

An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation

Frontiers in Immunology
IntroductionInterleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MAS ...
Liqiong Jiang, Lars P. Lunding, Lars P. Lunding, William S. Webber, Karsten Beckmann, Tania Azam, Jesper Falkesgaard Højen, Jesper Falkesgaard Højen, Jesus Amo-Aparicio, Alberto Dinarello, Tom T. Nguyen, Ulrich Pessara, Ulrich Pessara, Daniel Parera, Daniel Parera, David J. Orlicky, Stephan Fischer, Stephan Fischer, Michael Wegmann, Michael Wegmann, Charles A. Dinarello, Suzhao Li   +21 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source