Results 21 to 30 of about 7,408,636 (290)

Structural Basis of IL-1 Family Cytokine Signaling

Frontiers in Immunology, 2019
Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
James K. Fields, James K. Fields, James K. Fields, Sebastian Günther, Eric J. Sundberg, Eric J. Sundberg, Eric J. Sundberg   +6 more
doaj   +1 more source

Thrombin antithrombin complex and IL-18 serum levels in stroke patients

Neurology International, 2010
The complex picture of inflammation and coagulation alterations comes to life in acute stroke phases. Increasing evidence points to a strong interaction and extensive crosstalk between the inflammation and coagulation systems: the interest towards this ...
Ornella Piazza, Giuliana Scarpati, Simona Cotena, Maria Lonardo, Rosalba Tufano   +4 more
doaj   +1 more source

Different members of the IL-1 family come out in different ways: DAMPs vs cytokines?

Frontiers in Immunology, 2013
Intercellular communications control fundamental biological processes required for the survival of multicellular organisms. Secretory proteins are among the most important messengers in this network of information.
Sonia eCarta, Rosa eLavieri, Anna eRubartelli   +2 more
doaj   +1 more source

Bidirectional Action of Cenicriviroc, a CCR2/CCR5 Antagonist, Results in Alleviation of Pain-Related Behaviors and Potentiation of Opioid Analgesia in Rats With Peripheral Neuropathy

Frontiers in Immunology, 2020
Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the effects of available analgesics, including opioids. Converging evidence indicates the functional interactions between chemokine and opioid receptors and their ...
Klaudia Kwiatkowski, Katarzyna Pawlik, Katarzyna Ciapała, Anna Piotrowska, Wioletta Makuch, Joanna Mika   +5 more
doaj   +1 more source

Choline uptake and metabolism modulate macrophage IL-1β and IL-18 production

Cell Metabolism, 2019
SUMMARY Choline is a vitamin-like nutrient that is taken up via specific transporters and metabolized by choline kinase which converts it to phosphocholine needed for de novo synthesis of phosphatidylcholine (PC), the main phospholipid of cellular ...
E. Sanchez-Lopez, Zhenyu Zhong, A. Stubelius, Shannon R. Sweeney, L. Booshehri, L. Antonucci, R. Liu-Bryan, A. Lodi, R. Terkeltaub, J. Lacal, A. Murphy, H. Hoffman, S. Tiziani, M. Guma, M. Karin   +14 more
semanticscholar   +1 more source

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury.

Kidney International, 2019
Inflammation and tubular cell death are the hallmarks of acute kidney injury (AKI). However, the precise mechanism underlying these effects has not been fully elucidated.
Naijun Miao, Fan Yin, Hong-yan Xie, Yan-zhe Wang, Yiang Xu, Yang Shen, Dan Xu, Jianyong Yin, Bao Wang, Zhuan-li Zhou, Q. Cheng, Pan-pan Chen, H. Xue, Li Zhou, J. Liu, Xiaoxia Wang, Wei Zhang, Li-min Lu   +17 more
semanticscholar   +1 more source

Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis

Pathogens, 2020
A thorough understanding of the processes modulating the innate and acquired immune response to Mycobacterium tuberculosis (M.tb) infection in the context of gene expression is still a scientific and diagnostic problem.
Sebastian Wawrocki, Grzegorz Kielnierowski, Wieslawa Rudnicka, Michal Seweryn, Magdalena Druszczynska   +4 more
doaj   +1 more source

IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome.

Rheumatology, 2019
OBJECTIVES Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS.
S. Yasin, N. Fall, R. A. Brown, Maggie Henderlight, S. Canna, C. Girard-Guyonvarc’h, C. Gabay, A. Grom, G. Schulert   +8 more
semanticscholar   +1 more source

IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells

Journal of Immunotherapy for Cancer, 2019
BackgroundNatural killer (NK) cells are an emerging new tool for cancer immunotherapy. To develop NK cell therapeutics from peripheral blood mononuclear cells (PBMCs) of healthy donors, substantial expansion of primary NK cells is necessary because of ...
Y. Choi, E. Lim, Se Wha Kim, Y. Moon, Kyung-Soon Park, H. An   +5 more
semanticscholar   +1 more source

Increased Serum Levels of Growth-Differentiation Factor 3 (GDF3) and Inflammasome-Related Markers in Pregnant Women during Acute Zika Virus Infection

Viruses, 2022
The systemic inflammatory response elicited by acute Zika virus (ZIKV) infection during pregnancy plays a key role in the clinical outcomes in mothers and congenitally infected offspring.
Carlos Eduardo de Castro Alves, Sabrina Araújo de Melo, Jean de Melo Silva, Leonardo Calheiros de Oliveira, Valdinete Alves do Nascimento, João Hugo Abdalla Santos, Felipe Gomes Naveca, Gemilson Soares Pontes   +7 more
doaj   +1 more source