INFLUENCE OF AN INHIBITOR OF JNK ON THE SECRETION OF THE INFLAMMASOME–DEPENDENT PROINFLAMMATORY CYTOKINES [PDF]
Journal of IMAB, 2020 Purpose: In this study, we determine the influence of prolonged exposure on organic air pollutants, on the secretion of inflammasome-dependent cytokines IL-1β and IL-18.
Boncho Grigorov +3 more
doaj +1 more source
Research progress of NLRP3 inflammasome in the pathogenesis of psoriasis
Pifu-xingbing zhenliaoxue zazhi, 2022 NLRP3 inflammasome activates IL-1β and IL-18. In recent years, a large number of in vitro and in vivo studies showed elevations in expression levels of NLRP3 inflammasome, IL-1β and IL-18 in psoriasis.
Siman SHI +4 more
doaj +1 more source
Pyroptosis in Osteoblasts: A Novel Hypothesis Underlying the Pathogenesis of Osteoporosis
Frontiers in Endocrinology, 2021 Osteoporosis has become a worldwide disease characterized by a reduction in bone mineral density and the alteration of bone architecture leading to an increased risk of fragility fractures.
Zhengbo Tao +10 more
doaj +1 more source
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
Nature, 2020 Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2.
Ting Zhou +13 more
semanticscholar +1 more source
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Cell, 2020 SUMMARY Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here,
Abigail Jarret +25 more
semanticscholar +1 more source
Toxics, 2022 Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further understand the roles of IL-18BP in radiation mitigation, we studied
Wanchang Cui +6 more
doaj +1 more source
Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis
Aging, 2020 Interleukin 18 (IL-18) promotes inflammation and apoptosis in chondrocytes, thereby contributing to the development and progression of osteoarthritis (OA).
Jia‐peng Bao +4 more
semanticscholar +1 more source
Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University Hospital [PDF]
Egyptian Journal of Medical Research, 2022 A cross-sectional, analytical study conducted over a period of 6 months from April to September 2021 after the approval of REC on 50 patients with confirmed positive of COVID-19 by SARS-CoV-2 nucleic acid RT-PCR recruited from Isolation departments and ...
Nada El-Sagheer +3 more
doaj +1 more source
Process Mining Organization (PMO) Modeling and Healthcare Processes
Knowledge, 2023 Process mining organizatioQn (PMO) is an innovative approach based on artificial intelligence (AI) decision making suitable for designing healthcare processes for human resource (HR) organizations.
Angelo Rosa, Alessandro Massaro
doaj +1 more source
Interleukin-18 and IL-18BP in inflammatory dermatological diseases
Frontiers in Immunology, 2023 Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xiaoyun Wang +8 more
doaj +1 more source