Effect of IL-18 on the Expansion and Phenotype of Human Natural Killer Cells: Application to Cancer Immunotherapy [PDF]
International Journal on Biological Sciences, 2018 When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18.
H. Senju +11 more
semanticscholar +2 more sources
IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions
Frontiers in Immunology, 2019 The IL-1 cytokines are a newly expanded family, with each of its 11 members playing an important role in health and disease. Typically acting as pro- or anti-inflammatory mediators of first-line innate immunity, their production is particularly important
Michelle A. Williams +2 more
doaj +2 more sources
Interleukin-18 and IL-18 Binding Protein [PDF]
Frontiers in Immunology, 2013 Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine but unlike IL-1β, the IL-18 precursor is constitutively present ...
C. Dinarello +3 more
semanticscholar +2 more sources
Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases
Frontiers in Pharmacology, 2017 In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs).
Gabriele Fenini +2 more
doaj +2 more sources
Biomedical PapersAims. The present study aimed to assess vitamin D status and serum concentrations of pro-inflammatory cytokines IL-17, Il-23, and IL-18 in patients with chronic plaque psoriasis and their association with various demographic and clinical characteristics.
Maria Ganeva +5 more
doaj +2 more sources
IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models
Journal of Clinical Investigation, 2023 Patients with small cell lung cancer (SCLC) generally have a poor prognosis and a median overall survival of only about 13 months, indicating the urgent need for novel therapies.
J. Jaspers +6 more
semanticscholar +1 more source
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence
Nature Communications, 2022 IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by
Hung-Yu Chiang +6 more
semanticscholar +1 more source
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
Nature, 2020 Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2.
Ting Zhou +12 more
semanticscholar +1 more source
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Cell, 2020 SUMMARY Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here,
Abigail Jarret +25 more
semanticscholar +1 more source
Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis
Aging, 2020 Interleukin 18 (IL-18) promotes inflammation and apoptosis in chondrocytes, thereby contributing to the development and progression of osteoarthritis (OA).
Jia-Peng Bao +4 more
semanticscholar +1 more source