Interleukin-18 and interleukin-18 Binding Protein [PDF]
Frontiers in Immunology, 2013 Interleukin-18 (IL 18) is a member of the IL 1 family of cytokines. Increasing reports have expanded the role of IL 18 in mediating inflammation in animal models of disease using IL 18 deficient mice, neutralization of IL 18 or deficiency in the IL 18 ...
Charles eDinarello +6 more
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IL-27 Regulates IL-18 binding protein in skin resident cells. [PDF]
PLoS ONE, 2012 IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased ...
Miriam Wittmann +5 more
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Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18 [PDF]
Frontiers in Immunology, 2017 The cytokine interleukin (IL)-18 is a crucial amplifier of natural killer (NK) cell function. IL-18 signaling is regulated by the inhibitory effects of IL-18 binding protein (IL-18BP).
Robert Z. Harms +5 more
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Interleukin‐18, IL‐18 binding protein and IL‐18 receptor expression in asthma: a hypothesis showing IL‐18 promotes epithelial cell differentiation [PDF]
Clinical & Translational Immunology, 2021 Objective In asthma, genome‐wide association studies have shown that interleukin‐18 (IL‐18) receptor 1 gene (IL‐18R1) and sputum IL‐18 are increased during exacerbations. However, the role of the IL‐18 axis in bronchial epithelial function is unclear. To
Davinder Kaur +4 more
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IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria [PDF]
BMC Infectious Diseases, 2021 Background Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes.
Kari Otterdal +9 more
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Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis [PDF]
Pathogens, 2020 A thorough understanding of the processes modulating the innate and acquired immune response to Mycobacterium tuberculosis (M.tb) infection in the context of gene expression is still a scientific and diagnostic problem.
Sebastian Wawrocki +4 more
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IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2021 Idiopathic pulmonary fibrosis is a chronic, fibrosing interstitial pneumonia that presents with various clinical courses and progression ranging from rapid to slow.
Yu Nakanishi +11 more
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Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. [PDF]
J Biol Chem, 2022 Human Interleukin-18 (IL-18) is an omnipresent proinflammatory cytokine of the IL-1 family with central roles in autoimmune and inflammatory diseases and serves as a staple biomarker in the evaluation of inflammation in physiology and disease, including ...
Detry S +5 more
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Molecular cloning and characterisation of chicken IL-18 binding protein.
Dev Comp Immunol, 2021 The human IL-1 receptor family is comprised of 11 membrane bound or soluble receptors and the IL-18 binding protein (IL-18BP). These receptors are dispersed across seven genomic loci, with the majority at a single locus.
Gibson MS +4 more
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Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis [PDF]
Cell Reports MedicineSummary: Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disease characterized by inflammation and fibrosis, with enhanced interleukin-18 (IL-18) signaling. IL-18-binding protein (IL-18BP) neutralizes IL-18, but its therapeutic
Dong-Hyun Kim +16 more
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