Results 21 to 30 of about 741,206 (288)

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Frontiers in Immunology, 2023
Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xiaoyun Wang, Xiaoyun Wang, Lian Wang, Xiang Wen, Lu Zhang, Xian Jiang, Xian Jiang, Gu He, Gu He   +8 more
doaj   +1 more source

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition

mAbs, 2023
Here, we generated bispecific antibody (bsAb) derivatives that mimic the function of interleukin (IL)-18 based on single domain antibodies (sdAbs) specific to IL-18 Rα and IL-18 Rβ.
Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer, Lars Toleikis, Simon Krah, Achim Doerner, Desislava Yanakieva, Ammelie Svea Boje, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Harald Kolmar, Lukas Pekar, Stefan Zielonka   +16 more
doaj   +1 more source

The IL-18 Antagonist IL-18–Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment [PDF]

Clinical Cancer Research, 2013
Abstract Purpose: Interleukin (IL)-18 is an immune-enhancing cytokine, which induces IFN-γ production, T-helper 1 responses, and antitumor effects. In turn, IFN-γ stimulates IL-18–binding protein production, which blocks IL-18 activity.
Grazia, Carbotti, Gaia, Barisione, Anna Maria, Orengo, Antonella, Brizzolara, Irma, Airoldi, Marina, Bagnoli, Patrizia, Pinciroli, Delia, Mezzanzanica, Maria Grazia, Centurioni, Marina, Fabbi, Silvano, Ferrini   +10 more
openaire   +2 more sources

Altered expression of IL-18, IL-18 binding protein and IL-18 receptor in blood monocytes of patients with allergic rhinitis [PDF]

, 2020
Abstract Background: Interleukin (IL)-18 is emerging as an attractive participant in allergic rhinitis (AR). However, correlation of IL-18 with IL-18 binding protein (BP) in plasma, and expression of IL-18, IL-18BP and IL-18 receptor (R) in AR blood monocytes remain obscure.Methods: We investigated IL-18, IL-18BP and IL-18R expression in ...
Junling Wang, Fangqiu Gu, Zhi Li, Mengmeng Zhan, Ling Wang, Huiyun Zhang, Dong Chen, Hua Xie, Ruonan Chai, Nan Zhao, Ruiming Yang, Yalin Hu, Shaoheng He   +12 more
openaire   +3 more sources

IL-18 and IL-18 binding protein are related to severity of myelodysplastic syndromes

, 2022
AbstractBackground Myelodysplastic syndromes (MDS) was defined as a clonal hematopoietic disorder disease. Although current stratified therapy for MDS has greatly improved overall survival, there is still a subset of them who suffered from progression to AML with a poor prognosis. Immune factors play essential roles in the pathogenesis and evolution of
Ting Wang, NingYuan Ran, Nianbin Li, Mengtong Zang, Xin He, Qiulin Chen, Rong Fu, Zonghong Shao   +7 more
openaire   +1 more source

Effects of statins on TH1 modulating cytokines in human subjects [PDF]

PeerJ, 2015
Background. Activation of the innate immune system by cholesterol accelerates atherosclerosis. High levels or modified forms of cholesterol stimulate release of the inflammatory cytokines IL-12 and IL-18 that synergistically stimulate T lymphocytes to ...
Thomas R. Cimato, Beth A. Palka
doaj   +2 more sources

IL-18 Binding Protein Protects Against Contact Hypersensitivity [PDF]

The Journal of Immunology, 2003
Abstract Allergic contact dermatitis, the clinical manifestation of contact hypersensitivity, is one of the most common disorders of the skin. It is elicited upon multiple cutaneous re-exposure of sensitized individuals to the sensitizing agent.
Thomas, Plitz, Pierre, Saint-Mézard, Masataka, Satho, Susanne, Herren, Caroline, Waltzinger, Marcelo, de Carvalho Bittencourt, Marie H, Kosco-Vilbois, Yolande, Chvatchko   +7 more
openaire   +2 more sources

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18 [PDF]

Proceedings of the National Academy of Sciences, 2000
A novel, constitutively expressed and secreted IL-18 binding protein (IL-18BP) neutralizes IL-18 and thereby suppresses the production of IFN-γ, resulting in reduced T-helper type 1 immune responses. In the present study, four human and two mouse isoforms, resulting from mRNA splicing and found in various cDNA libraries, were expressed, purified, and ...
S H, Kim, M, Eisenstein, L, Reznikov, G, Fantuzzi, D, Novick, M, Rubinstein, C A, Dinarello   +6 more
openaire   +2 more sources

Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]

, 2008
Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Jens Paulukat, Heiko Mühl, Malte Bachmann, Josef Pfeilschifter, Pfeilschifter, Josef, Bachmann, Malte, Mühl, Heiko, Paulukat, Jens   +7 more
core   +1 more source

Expression, Purification and Structural Analysis of Human IL-18 Binding Protein: A Potent Therapeutic Molecule for Allergy

Allergology International, 2008
Background: While interleukin-18 (IL-18) plays an important role in the innate and adaptive immune responses, it can also cause severe allergic inflammatory reactions. Thus it is a molecule currently being targeted for therapy.
Takeshi Kimura, Zenichiro Kato, Hidenori Ohnishi, Hidehito Tochio, Masahiro Shirakawa, Naomi Kondo   +5 more
doaj   +1 more source