Results 21 to 30 of about 72,835,347 (270)
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity [PDF]
Proceedings of the National Academy of Sciences, 2002 IL-1F7 was discovered in expressed sequence tag databases as a member of the increasing family of proteins sharing sequence homology to IL-1α/β, IL-1Ra, and IL-18. In the present study using immunohistochemical staining, IL-1F7 was localized in human peripheral monocytic cells, suggesting its role in immune regulation.
P. Bufler +6 more
semanticscholar +3 more sources
Toxics, 2022 Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further understand the roles of IL-18BP in radiation mitigation, we studied
Wanchang Cui +6 more
doaj +1 more source
Interleukin-18 and IL-18BP in inflammatory dermatological diseases
Frontiers in Immunology, 2023 Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xiaoyun Wang +8 more
doaj +1 more source
Journal of Translational Medicine, 2021 Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patients with osteoarthritis (OA) or in healthy ...
Hong-Ki Min +5 more
semanticscholar +1 more source
IL-18 binding protein-producing cells attenuate anemia in murine macrophage activation syndrome
Journal of Immunology, 2023 Interleukin (IL)-18 is a pleiotropic immunoregulatory cytokine of the IL-1 family. IL-18 has been first identified as a potent IFN-γ inducer in synergy with IL-12 and IL-15 and thus, as a powerful T helper 1 cell polarizing cytokine.
M. Harel +4 more
semanticscholar +1 more source
mAbs, 2023 Here, we generated bispecific antibody (bsAb) derivatives that mimic the function of interleukin (IL)-18 based on single domain antibodies (sdAbs) specific to IL-18 Rα and IL-18 Rβ.
Britta Lipinski +16 more
doaj +1 more source
Expression and Release of IL-18 Binding Protein in Response to IFN-γ1 [PDF]
The Journal of Immunology, 2001 Abstract IL-18 and IL-18 binding protein (IL-18BP) are two newly described opponents in the cytokine network. Local concentrations of these two players may determine biological functions of IL-18 in the context of inflammation, infection, and cancer.
J. Paulukat +9 more
semanticscholar +3 more sources
Asian Pacific Journal of Cancer Prevention, 2022 Background: IL-18binding protein (IL-18BP) might play a role in tumor escape from immune surveillance through interacting with IL-37. Such interactions modulate the antitumor activity of IL-18 and affect regulatory T cell (Treg) function.
M. Haghshenas +5 more
semanticscholar +1 more source
Effects of statins on TH1 modulating cytokines in human subjects [PDF]
PeerJ, 2015 Background. Activation of the innate immune system by cholesterol accelerates atherosclerosis. High levels or modified forms of cholesterol stimulate release of the inflammatory cytokines IL-12 and IL-18 that synergistically stimulate T lymphocytes to ...
Thomas R. Cimato, Beth A. Palka
doaj +2 more sources
IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice
Scientific Reports, 2020 Recent studies suggested that radiation exposure causes local and systemic inflammatory responses and induces cell and tissue damage. We have reported that IL-18 plays an important role in radiation-induced injury. Here, we demonstrate that IL-18 binding
Xiang-Hong Li +5 more
semanticscholar +1 more source