Results 21 to 30 of about 820,192 (306)

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells [PDF]

Journal of Neuroinflammation, 2012
Background Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex.
Sutinen Elina M, Pirttilä Tuula, Anderson George, Salminen Antero, Ojala Johanna O   +4 more
doaj   +2 more sources

Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion. [PDF]

Ann Surg Treat Res, 2015
Purpose Severe local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is
Ozsoy M, Gonul Y, Bal A, Ozkececi ZT, Celep RB, Adali F, Hazman O, Koçak A, Tosun M.   +8 more
europepmc   +2 more sources

Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein 1 [PDF]

The Journal of Immunology, 2003
Abstract IL-18 is an important cytokine in autoimmune and inflammatory diseases through the induction of IFN-γ, TNF-α, and IL-1. We report herein that collagen-induced arthritis (CIA) in mice is inhibited by treatment with murine IL-18 binding protein (mIL-18BP).
N. Banda, Andrea Vondracek, Damian M. Kraus, C. Dinarello, Soohyun Kim, A. Bendele, G. Senaldi, W. Arend   +7 more
semanticscholar   +3 more sources

Normal Free Interleukin-18 (IL-18) Plasma Levels in Dengue Virus Infection and the Need To Measure Both Total IL-18 and IL-18 Binding Protein Levels [PDF]

Clinical and Vaccine Immunology, 2015
Activated monocytes/macrophages and T lymphocytes that produce a cytokine storm are assumed to play a pivotal role in the pathogenesis of dengue. Interleukin-18 (IL-18) is a proinflammatory cytokine that is increased during dengue and known to induce ...
M. Michels, Q. de Mast, M. Netea, L. Joosten, C. Dinarello, P. I. F. Rudiman, Sylvia Sinarta, R. Wisaksana, B. Alisjahbana, A. J. van der Ven   +9 more
semanticscholar   +4 more sources

IL-18 Binding Protein Protects Against Contact Hypersensitivity [PDF]

The Journal of Immunology, 2003
Abstract Allergic contact dermatitis, the clinical manifestation of contact hypersensitivity, is one of the most common disorders of the skin. It is elicited upon multiple cutaneous re-exposure of sensitized individuals to the sensitizing agent.
T. Plitz, P. Saint-Mézard, Masataka Satho, S. Herren, C. Waltzinger, M. De Carvalho Bittencourt, M. Kosco-Vilbois, Y. Chvatchko   +7 more
semanticscholar   +3 more sources

IL–18 and IL–18 binding protein levels in patients with dengue virus infection

Asian Pacific Journal of Tropical Medicine, 2010
AbstractObjectiveTo determine the levels of IL-18 and IL-18 binding protein (BP) in patients with dengue virus infection.MethodsAcute and convalescent sera were collected from each patient. Control group was sera from blood donors. The levels of both IL-18 and IL-18BP were measured by ELISA assays.ResultsIt was shown that IL-18 and IL-18BP levels were ...
Chirathaworn, Chintana, Poovorawan, Yong, Vuthitanachot, Viboonsak   +2 more
openaire   +2 more sources

Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein

Frontiers in Immunology, 2012
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition due to the association of an infectious agent with lymphocyte cytotoxicity defects, either of congenital genetic origin in children or presumably acquired in adults. In HLH patients,
Laura eChiossone, Laura eChiossone, Laura eChiossone, Sandra eAudonnet, Sandra eAudonnet, Sandra eAudonnet, Sandra eAudonnet, Bruno eChetaille, Lionel eChasson, Lionel eChasson, Lionel eChasson, Catherine eFarnarier, Yael eBerda-Haddad, Stefan eJordan, Ulrich eKoszinowski, Marc eDalod, Marc eDalod, Marc eDalod, Karin eMazodier, Daniela eNovick, Charles eDinarello, Eric eVivier, Eric eVivier, Eric eVivier, Eric eVivier, Gilles eKaplanski   +25 more
doaj   +2 more sources

Cloning and characterization of giant panda (Ailuropoda melanoleuca) IL-18 binding protein. [PDF]

Res Vet Sci, 2016
The giant panda (Ailuropoda melanoleuca) is an endangered species. Interleukin-18 (IL-18) plays an important role in the innate and adaptive immune responses by inducing IFN-γ. IL-18 has been implicated in the pathogenesis of various diseases. IL-18 binding protein (IL-18BP) is an intrinsic inhibitor of IL-18 that possesses higher affinity to IL-18. In
Yan Y, Deng J, Niu L, Wang Q, Yu J, Shao H, Cao Q, Zhang Y, Tan X.   +8 more
europepmc   +3 more sources

Variola virus IL-18 binding protein interacts with three human IL-18 residues that are part of a binding site for human IL-18 receptor alpha subunit

Virology, 2007
Interleukin-18 (IL-18) plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18 binding proteins (IL-18BP) that neutralize IL-18 activity. Here, we examined whether IL-18BP neutralizes IL-18 activity by binding to the same region of IL-18 where IL-18 receptor (IL-18R) binds.
Meng, Xiangzhi, Leman, Michael, Xiang, Yan   +2 more
openaire   +3 more sources

[Clinical significance of IL-18 and IL-18-binding protein in bone marrow of patients with myelodysplastic syndrome]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Objective: To analyze the level and clinical significance of IL-18 and IL-18-binding protein (BP) in the bone marrow of patients with myelodysplastic syndrome (MDS) . Methods: A total of 43 newly diagnosed patients with MDS who were admitted to the Department of Hematology, Tianjin Medical University General Hospital, from July 2020 to February 2021 ...
Wang T, Ran NY, Chen QL, Liu DL, Zang MT, Li NB, He X, Guan J, Fu R, Shao ZH.   +9 more
europepmc   +3 more sources