Results 31 to 40 of about 820,192 (306)

Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein [PDF]

Proceedings of the National Academy of Sciences, 2001
IL-18 can be considered a proinflammatory cytokine mediating disease as well as an immunostimulatory cytokine that is important for host defense against infection and cancer. The high-affinity, constitutively expressed, and circulating IL-18 binding protein (IL-18BP), which competes with cell surface receptors for IL-18 and ...
Soohyun Kim, T. Azam, D. Yoon, L. Reznikov, D. Novick, M. Rubinstein, C. Dinarello   +6 more
semanticscholar   +3 more sources

Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein. [PDF]

PLoS One, 2012
Background Modified Vaccinia Ankara (MVA) is an attenuated strain of Vaccinia virus (VACV) currently employed in many clinical trials against HIV/AIDS and other diseases.
Falivene J, Del Médico Zajac MP, Pascutti MF, Rodríguez AM, Maeto C, Perdiguero B, Gómez CE, Esteban M, Calamante G, Gherardi MM.   +9 more
europepmc   +2 more sources

PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis. [PDF]

Cardiovasc Res, 2015
Durpès MC, Morin C, Paquin-Veillet J, Beland R, Paré M, Guimond MO, Rekhter M, King GL, Geraldes P.   +8 more
europepmc   +2 more sources

Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design

Biomolecules
Cytokine-mediated immunotherapy has rapidly emerged as an effective alternative approach for cancer treatment by modulating the anti-tumor response.
Napat Prompat, Chariya Peeyatu, Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Varomyalin Tipmanee   +5 more
doaj   +2 more sources

Pharmacokinetic Study of rhIL-18BP and Its Effect on Radiation-Induced Cytokine Changes in Mouse Serum and Intestine

Toxics, 2022
Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further understand the roles of IL-18BP in radiation mitigation, we studied
Wanchang Cui, Lisa Hull, Alex Zizzo, Li Wang, Bin Lin, Min Zhai, Mang Xiao   +6 more
doaj   +1 more source

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Frontiers in Immunology, 2023
Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xiaoyun Wang, Xiaoyun Wang, Lian Wang, Xiang Wen, Lu Zhang, Xian Jiang, Xian Jiang, Gu He, Gu He   +8 more
doaj   +1 more source

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition

mAbs, 2023
Here, we generated bispecific antibody (bsAb) derivatives that mimic the function of interleukin (IL)-18 based on single domain antibodies (sdAbs) specific to IL-18 Rα and IL-18 Rβ.
Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer, Lars Toleikis, Simon Krah, Achim Doerner, Desislava Yanakieva, Ammelie Svea Boje, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Harald Kolmar, Lukas Pekar, Stefan Zielonka   +16 more
doaj   +1 more source

Altered expression of IL-18, IL-18 binding protein and IL-18 receptor in blood monocytes of patients with allergic rhinitis [PDF]

, 2020
Abstract Background: Interleukin (IL)-18 is emerging as an attractive participant in allergic rhinitis (AR). However, correlation of IL-18 with IL-18 binding protein (BP) in plasma, and expression of IL-18, IL-18BP and IL-18 receptor (R) in AR blood monocytes remain obscure.Methods: We investigated IL-18, IL-18BP and IL-18R expression in ...
Junling Wang, Fangqiu Gu, Zhi Li, Mengmeng Zhan, Ling Wang, Huiyun Zhang, Dong Chen, Hua Xie, Ruonan Chai, Nan Zhao, Ruiming Yang, Yalin Hu, Shaoheng He   +12 more
openaire   +3 more sources

IL-18 and IL-18 binding protein are related to severity of myelodysplastic syndromes

, 2022
AbstractBackground Myelodysplastic syndromes (MDS) was defined as a clonal hematopoietic disorder disease. Although current stratified therapy for MDS has greatly improved overall survival, there is still a subset of them who suffered from progression to AML with a poor prognosis. Immune factors play essential roles in the pathogenesis and evolution of
Ting Wang, NingYuan Ran, Nianbin Li, Mengtong Zang, Xin He, Qiulin Chen, Rong Fu, Zonghong Shao   +7 more
openaire   +1 more source

Effects of statins on TH1 modulating cytokines in human subjects [PDF]

PeerJ, 2015
Background. Activation of the innate immune system by cholesterol accelerates atherosclerosis. High levels or modified forms of cholesterol stimulate release of the inflammatory cytokines IL-12 and IL-18 that synergistically stimulate T lymphocytes to ...
Thomas R. Cimato, Beth A. Palka
doaj   +2 more sources