Results 31 to 40 of about 72,835,347 (270)
IL-18 and IL-18 binding protein are related to severity of myelodysplastic syndromes
, 2022 AbstractBackground Myelodysplastic syndromes (MDS) was defined as a clonal hematopoietic disorder disease. Although current stratified therapy for MDS has greatly improved overall survival, there is still a subset of them who suffered from progression to AML with a poor prognosis. Immune factors play essential roles in the pathogenesis and evolution of
Ting Wang +7 more
openaire +1 more source
Altered expression of IL-18, IL-18 binding protein and IL-18 receptor in blood monocytes of patients with allergic rhinitis [PDF]
, 2020 Abstract Background: Interleukin (IL)-18 is emerging as an attractive participant in allergic rhinitis (AR). However, correlation of IL-18 with IL-18 binding protein (BP) in plasma, and expression of IL-18, IL-18BP and IL-18 receptor (R) in AR blood monocytes remain obscure.Methods: We investigated IL-18, IL-18BP and IL-18R expression in ...
Junling Wang +12 more
openaire +3 more sources
Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]
, 2008 Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Jens Paulukat +7 more
core +1 more source
Allergology International, 2008 Background: While interleukin-18 (IL-18) plays an important role in the innate and adaptive immune responses, it can also cause severe allergic inflammatory reactions. Thus it is a molecule currently being targeted for therapy.
Takeshi Kimura +5 more
doaj +1 more source
Role of Interleukin-37 in Inflammatory and Autoimmune Diseases [PDF]
Iranian Journal of Immunology, 2018 Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 ...
Xiaoying Wang +4 more
doaj +1 more source
Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein 1 [PDF]
The Journal of Immunology, 2003 Abstract IL-18 is an important cytokine in autoimmune and inflammatory diseases through the induction of IFN-γ, TNF-α, and IL-1. We report herein that collagen-induced arthritis (CIA) in mice is inhibited by treatment with murine IL-18 binding protein (mIL-18BP).
N. Banda +7 more
semanticscholar +3 more sources
, 2003 Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B. +2 more
core +1 more source
IL-18 Binding Protein Protects Against Contact Hypersensitivity [PDF]
The Journal of Immunology, 2003 Abstract Allergic contact dermatitis, the clinical manifestation of contact hypersensitivity, is one of the most common disorders of the skin. It is elicited upon multiple cutaneous re-exposure of sensitized individuals to the sensitizing agent.
Thomas, Plitz +7 more
openaire +2 more sources
Journal of Immunology, 2020 Key Points Both radioresistant and radiosensitive cells produce Il-18bp during CpG-induced MAS. Il-18bp behaves as Ifn-γ signature gene during CpG-induced MAS. Elevated circulating levels of Il-18bp prevent systemic effects of Il-18 in MAS. IL-18 binding
M. Harel +4 more
semanticscholar +1 more source
cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]
, 2000 By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
Stäheli, Peter +15 more
core +1 more source