Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma [PDF]
Mediators of Inflammation, 2014 Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian
Liat Medina +5 more
doaj +4 more sources
IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome. [PDF]
J Immunol, 2023 Interleukin (IL)-18 is a pleiotropic immunoregulatory cytokine of the IL-1 family. IL-18 has been first identified as a potent IFN-γ inducer in synergy with IL-12 and IL-15 and thus, as a powerful T helper 1 cell polarizing cytokine.
Harel M +4 more
europepmc +2 more sources
IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis. [PDF]
J Transl Med, 2021 Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patients with osteoarthritis (OA) or in healthy ...
Min HK +5 more
europepmc +2 more sources
IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice. [PDF]
Sci Rep, 2020 Recent studies suggested that radiation exposure causes local and systemic inflammatory responses and induces cell and tissue damage. We have reported that IL-18 plays an important role in radiation-induced injury. Here, we demonstrate that IL-18 binding
Li X +5 more
europepmc +2 more sources
Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. [PDF]
Proceedings of the National Academy of Sciences, 2000 A novel, constitutively expressed and secreted IL-18 binding protein (IL-18BP) neutralizes IL-18 and thereby suppresses the production of IFN-γ, resulting in reduced T-helper type 1 immune responses. In the present study, four human and two mouse isoforms, resulting from mRNA splicing and found in various cDNA libraries, were expressed, purified, and ...
Soo-Hyun Kim +6 more
semanticscholar +3 more sources
IL-18 binding protein attenuates neuroinflammation and cognitive decline in Alzheimer’s disease [PDF]
Journal of NeuroinflammationNeuroinflammation in Alzheimer’s disease (AD) extends beyond a secondary response to amyloid-β plaques and neurofibrillary tangles, representing a fundamental driver of disease pathogenesis.
Dae Ki Hong +6 more
doaj +2 more sources
Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity. [PDF]
J ImmunolAbstract Interleukin (IL)-18 is an immunoregulatory cytokine that acts as a potent inducer of T helper 1 and cytotoxic responses. IL-18 activity is regulated by its decoy receptor IL-18 binding protein (IL-18BP), which forms a high-affinity complex with IL-18 to block binding of the cognate receptors.
Huard A +11 more
europepmc +3 more sources
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity [PDF]
Proceedings of the National Academy of Sciences, 2002 IL-1F7 was discovered in expressed sequence tag databases as a member of the increasing family of proteins sharing sequence homology to IL-1α/β, IL-1Ra, and IL-18. In the present study using immunohistochemical staining, IL-1F7 was localized in human peripheral monocytic cells, suggesting its role in immune regulation.
P. Bufler +6 more
semanticscholar +3 more sources
Expression and Release of IL-18 Binding Protein in Response to IFN-γ1 [PDF]
The Journal of Immunology, 2001 Abstract IL-18 and IL-18 binding protein (IL-18BP) are two newly described opponents in the cytokine network. Local concentrations of these two players may determine biological functions of IL-18 in the context of inflammation, infection, and cancer.
J. Paulukat +9 more
semanticscholar +3 more sources
The IL-18 Antagonist IL-18–Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment [PDF]
Clinical Cancer Research, 2013 Purpose: Interleukin (IL)-18 is an immune-enhancing cytokine, which induces IFN-γ production, T-helper 1 responses, and antitumor effects. In turn, IFN-γ stimulates IL-18–binding protein production, which blocks IL-18 activity.
Grazia Carbotti +10 more
semanticscholar +3 more sources