Results 11 to 20 of about 741,206 (288)

IL-18 binding protein attenuates neuroinflammation and cognitive decline in Alzheimer’s disease [PDF]

Journal of Neuroinflammation
Neuroinflammation in Alzheimer’s disease (AD) extends beyond a secondary response to amyloid-β plaques and neurofibrillary tangles, representing a fundamental driver of disease pathogenesis.
Dae Ki Hong, Seung Hoon Jeon, Minwoo Kang, Sowon Lee, Xia Liu, Eun Hee Ahn, Seong Su Kang   +6 more
doaj   +2 more sources

Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma [PDF]

Mediators of Inflammation, 2014
Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian
Liat Medina, Alex Rabinovich, Benjamin Piura, Victor Dyomin, Ruthy Shaco Levy, Mahmoud Huleihel   +5 more
doaj   +3 more sources

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells [PDF]

Journal of Neuroinflammation, 2012
Background Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex.
Sutinen Elina M, Pirttilä Tuula, Anderson George, Salminen Antero, Ojala Johanna O   +4 more
doaj   +3 more sources

Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis [PDF]

Cell Reports Medicine
Summary: Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disease characterized by inflammation and fibrosis, with enhanced interleukin-18 (IL-18) signaling. IL-18-binding protein (IL-18BP) neutralizes IL-18, but its therapeutic
Dong-Hyun Kim, Gona Choi, Eun-Bi Song, Hanna Lee, Jaehui Kim, Young-Saeng Jang, JinJoo Park, Susan Chi, Jaekyu Han, Sun-Mi Kim, Dongyoon Kim, Soo Han Bae, Hye Won Lee, Jun Yong Park, Seung Goo Kang, Sang-Hoon Cha, Yong-Hyun Han   +16 more
doaj   +2 more sources

IL–18 and IL–18 binding protein levels in patients with dengue virus infection [PDF]

Asian Pacific Journal of Tropical Medicine, 2010
AbstractObjectiveTo determine the levels of IL-18 and IL-18 binding protein (BP) in patients with dengue virus infection.MethodsAcute and convalescent sera were collected from each patient. Control group was sera from blood donors. The levels of both IL-18 and IL-18BP were measured by ELISA assays.ResultsIt was shown that IL-18 and IL-18BP levels were ...
Chirathaworn, Chintana, Poovorawan, Yong, Vuthitanachot, Viboonsak   +2 more
openaire   +2 more sources

Cloning and characterization of giant panda (Ailuropoda melanoleuca) IL-18 binding protein. [PDF]

Res Vet Sci, 2016
The giant panda (Ailuropoda melanoleuca) is an endangered species. Interleukin-18 (IL-18) plays an important role in the innate and adaptive immune responses by inducing IFN-γ. IL-18 has been implicated in the pathogenesis of various diseases. IL-18 binding protein (IL-18BP) is an intrinsic inhibitor of IL-18 that possesses higher affinity to IL-18. In
Yan Y, Deng J, Niu L, Wang Q, Yu J, Shao H, Cao Q, Zhang Y, Tan X.   +8 more
europepmc   +3 more sources

Variola virus IL-18 binding protein interacts with three human IL-18 residues that are part of a binding site for human IL-18 receptor alpha subunit [PDF]

Virology, 2007
Interleukin-18 (IL-18) plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18 binding proteins (IL-18BP) that neutralize IL-18 activity. Here, we examined whether IL-18BP neutralizes IL-18 activity by binding to the same region of IL-18 where IL-18 receptor (IL-18R) binds.
Meng, Xiangzhi, Leman, Michael, Xiang, Yan   +2 more
openaire   +3 more sources

[Clinical significance of IL-18 and IL-18-binding protein in bone marrow of patients with myelodysplastic syndrome]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Objective: To analyze the level and clinical significance of IL-18 and IL-18-binding protein (BP) in the bone marrow of patients with myelodysplastic syndrome (MDS) . Methods: A total of 43 newly diagnosed patients with MDS who were admitted to the Department of Hematology, Tianjin Medical University General Hospital, from July 2020 to February 2021 ...
Wang T, Ran NY, Chen QL, Liu DL, Zang MT, Li NB, He X, Guan J, Fu R, Shao ZH.   +9 more
europepmc   +3 more sources

Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design [PDF]

Biomolecules
Cytokine-mediated immunotherapy has rapidly emerged as an effective alternative approach for cancer treatment by modulating the anti-tumor response.
Napat Prompat, Chariya Peeyatu, Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Varomyalin Tipmanee   +5 more
doaj   +2 more sources

Pharmacokinetic Study of rhIL-18BP and Its Effect on Radiation-Induced Cytokine Changes in Mouse Serum and Intestine

Toxics, 2022
Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further understand the roles of IL-18BP in radiation mitigation, we studied
Wanchang Cui, Lisa Hull, Alex Zizzo, Li Wang, Bin Lin, Min Zhai, Mang Xiao   +6 more
doaj   +1 more source