Results 11 to 20 of about 72,835,347 (270)

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity

Journal of Biological Chemistry, 2022
Human Interleukin-18 (IL-18) is an omnipresent proinflammatory cytokine of the IL-1 family with central roles in autoimmune and inflammatory diseases and serves as a staple biomarker in the evaluation of inflammation in physiology and disease, including ...
S. Detry, Julien Andriès, Y. Bloch, C. Gabay, Danielle M. Clancy, S. Savvides   +5 more
semanticscholar   +6 more sources

Normal Free Interleukin-18 (IL-18) Plasma Levels in Dengue Virus Infection and the Need To Measure Both Total IL-18 and IL-18 Binding Protein Levels [PDF]

Clinical and Vaccine Immunology, 2015
Activated monocytes/macrophages and T lymphocytes that produce a cytokine storm are assumed to play a pivotal role in the pathogenesis of dengue. Interleukin-18 (IL-18) is a proinflammatory cytokine that is increased during dengue and known to induce ...
M. Michels, Q. de Mast, M. Netea, L. Joosten, C. Dinarello, P. I. F. Rudiman, Sylvia Sinarta, Rudi Wisaksana, B. Alisjahbana, A. van der Ven   +9 more
semanticscholar   +5 more sources

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells [PDF]

Journal of Neuroinflammation, 2012
Background Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex.
Sutinen Elina M, Pirttilä Tuula, Anderson George, Salminen Antero, Ojala Johanna O   +4 more
doaj   +3 more sources

Molecular cloning and characterisation of chicken IL-18 binding protein

Developmental & Comparative Immunology, 2020
The human IL-1 receptor family is comprised of 11 membrane bound or soluble receptors and the IL-18 binding protein (IL-18BP). These receptors are dispersed across seven genomic loci, with the majority at a single locus.
M. Gibson, Angela Steyn, D. Kealy, B. Kaspers, M. Fife   +4 more
semanticscholar   +3 more sources

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases

Biomedicines, 2022
Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Seung Yong Park, Yasmin Hisham, Hyun Mu Shin, Su Cheong Yeom, Soohyun Kim   +4 more
doaj   +2 more sources

The IL-18 Antagonist IL-18–Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment [PDF]

Clinical Cancer Research, 2013
Purpose: Interleukin (IL)-18 is an immune-enhancing cytokine, which induces IFN-γ production, T-helper 1 responses, and antitumor effects. In turn, IFN-γ stimulates IL-18–binding protein production, which blocks IL-18 activity.
Grazia Carbotti, G. Barisione, A. Orengo, A. Brizzolara, I. Airoldi, M. Bagnoli, P. Pinciroli, D. Mezzanzanica, M. Centurioni, M. Fabbi, S. Ferrini   +10 more
semanticscholar   +3 more sources

Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion

Annals of Surgical Treatment and Research, 2015
Purpose Severe local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is
Mustafa Özsoy, Yucel Gonul, A. Bal, Z. T. Ozkececi, R. B. Celep, Fahri Adalı, Omer Hazman, A. Koçak, M. Tosun   +8 more
semanticscholar   +2 more sources

IL-18 binding protein attenuates neuroinflammation and cognitive decline in Alzheimer’s disease

Journal of Neuroinflammation
Neuroinflammation in Alzheimer’s disease (AD) extends beyond a secondary response to amyloid-β plaques and neurofibrillary tangles, representing a fundamental driver of disease pathogenesis.
Dae Ki Hong, Seung Hoon Jeon, Minwoo Kang, Sowon Lee, Xia Liu, Eun Hee Ahn, Seong Su Kang   +6 more
doaj   +4 more sources

Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design

Biomolecules
Cytokine-mediated immunotherapy has rapidly emerged as an effective alternative approach for cancer treatment by modulating the anti-tumor response.
Napat Prompat, Chariya Peeyatu, Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Varomyalin Tipmanee   +5 more
doaj   +2 more sources

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. [PDF]

Proceedings of the National Academy of Sciences, 2000
A novel, constitutively expressed and secreted IL-18 binding protein (IL-18BP) neutralizes IL-18 and thereby suppresses the production of IFN-γ, resulting in reduced T-helper type 1 immune responses. In the present study, four human and two mouse isoforms, resulting from mRNA splicing and found in various cDNA libraries, were ...
Soo-Hyun Kim, Miriam Eisenstein, L. Reznikov, G. Fantuzzi, D. Novick, Menachem Rubinstein, C. A. Dinarello   +6 more
semanticscholar   +3 more sources