Results 41 to 50 of about 741,206 (288)

A role for IL-18 in protective immunity against Mycobacterium tuberculosis. [PDF]

, 2009
Tuberculosis remains the most hazardous bacterial infection worldwide. The causative agent, Mycobacterium tuberculosis, is a facultative intracellular pathogen of resting MPhi.
Hagens, Kristine, Bärbel Raupach, Stefan H. E. Kaufmann, Kaufmann, Stefan H. E., Daniel Korbel, Schneider, Bianca E, Schneider, Bianca E., Raupach, Bärbel, Enders, Jana, Jana Enders, Markus Koch, Kaufmann, Stefan HE, Hans-Willi Mittrücker, Bianca E. Schneider, Ulrich E. Schaible, Korbel, Daniel, Schaible, Ulrich E, Mittrücker, Hans-Willi, Schaible, Ulrich E., Koch, Markus, Kristine Hagens   +20 more
core   +1 more source

High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura

Haematologica, 2009
To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-γ, IL-4 plasma levels and platelet counts ...
Ning-ning Shan, Xiao-juan Zhu, Qian Wang, Chun-yan Wang, Ping Qin, Jun Peng, Ming Hou   +6 more
doaj   +1 more source

IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii

Cell Reports, 2023
Summary: Interleukin-18 (IL-18) promotes natural killer (NK) and T cell production of interferon (IFN)-γ, a key factor in resistance to Toxoplasma gondii, but previous work has shown a limited role for endogenous IL-18 in control of this parasite ...
Joseph T. Clark, Orr-El Weizman, Daniel L. Aldridge, Lindsey A. Shallberg, Julia Eberhard, Zachary Lanzar, Devon Wasche, John D. Huck, Ting Zhou, Aaron M. Ring, Christopher A. Hunter   +10 more
doaj   +1 more source

Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales [PDF]

, 2011
Single-stranded DNA binding proteins (SSBs) based on the OB-fold are considered ubiquitous in nature and play a central role in many DNA transactions including replication, recombination and repair.
Kroonin, Eugene V., Naismith, Jim, McMahon, Stephen, White, Malcolm F, Sonia Paytubi, Catherine H. Botting, Graham, Shirley, Botting, Catherine Helen, James H. Naismith, Malcolm F. White, Paytubi, Sonia, Shirley Graham, Liu, Huanting, Kira S. Makarova, Makarova, Kira S., Stephen A. McMahon, Huanting Liu, Eugene V. Koonin   +17 more
core   +1 more source

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]

, 2004
Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas, Goff, JP, Goff, Jesse P, Lippolis, JD, John D. Lippolis, Paape, Max, Bannerman, Douglas D, Paape, Max J, Kimura, K, Jayne C. Hope, Hope, Jayne C, Kimura, Kayoko, Lippolis, John D, Douglas D. Bannerman, Max J. Paape, Lippolis, John, Hope, Jayne, Kayoko Kimura, Hope, Jayne; id_orcid, Jesse P. Goff, Goff, Jesse   +20 more
core   +1 more source

Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis [PDF]

, 2011
This work was supported by grants from the Wellcome Trust and BBSRC. GRP was supported by a Wellcome Trust Prize Studentship. The C. elegans strain used in this work was provided by the Caenorhabditis Genetics Center, which is funded by the National ...
Haynes, Lee P., Burgoyne, Robert D., Walmesley Alice, Burgoyne Robert D., James R Johnson, Gerald R. Prescott, Barclay, Jeff W., Robert D. Burgoyne, Johnson James R., James R. Johnson, Prescott, Gerald R., Gerald R Prescott, Lee P. Haynes, Morgan, Alan, Margaret E Graham, Walmesley, Alice, Johnson, James R., Jeff W Barclay, Prescott Gerald R., Jeff W. Barclay, Lee P Haynes, Jones Mathew, Graham, Margaret E., Morgan Alan, Margaret E. Graham, Jones, Mathew, Alan Morgan, Barclay Jeff W., Robert D Burgoyne, Mathew Jones, Graham Margaret E., Haynes Lee P., Alice Walmesley   +32 more
core   +1 more source

Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein

Frontiers in Immunology, 2012
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition due to the association of an infectious agent with lymphocyte cytotoxicity defects, either of congenital genetic origin in children or presumably acquired in adults. In HLH patients,
Laura eChiossone, Laura eChiossone, Laura eChiossone, Sandra eAudonnet, Sandra eAudonnet, Sandra eAudonnet, Sandra eAudonnet, Bruno eChetaille, Lionel eChasson, Lionel eChasson, Lionel eChasson, Catherine eFarnarier, Yael eBerda-Haddad, Stefan eJordan, Ulrich eKoszinowski, Marc eDalod, Marc eDalod, Marc eDalod, Karin eMazodier, Daniela eNovick, Charles eDinarello, Eric eVivier, Eric eVivier, Eric eVivier, Eric eVivier, Gilles eKaplanski   +25 more
doaj   +1 more source

Interleukin-18 in Inflammatory Kidney Disease

Frontiers in Medicine, 2021
Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response.
Yasuaki Hirooka, Yuji Nozaki
doaj   +1 more source

Normal Free Interleukin-18 (IL-18) Plasma Levels in Dengue Virus Infection and the Need To Measure Both Total IL-18 and IL-18 Binding Protein Levels [PDF]

Clinical and Vaccine Immunology, 2015
ABSTRACT Activated monocytes/macrophages and T lymphocytes that produce a cytokine storm are assumed to play a pivotal role in the pathogenesis of dengue. Interleukin-18 (IL-18) is a proinflammatory cytokine that is increased during dengue and known to induce gamma interferon (IFN-γ), which is crucial for dengue immune response ...
Michels, M., Mast, Q. de, Netea, M.G., Joosten, L.A.B., Dinarello, C.A., Rudiman, P.I., Sinarta, S., Wisaksana, R., Alisjahbana, B., Ven, A. van der   +9 more
openaire   +3 more sources

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source