Results 41 to 50 of about 72,835,347 (270)

IL-18BP Improves Early Graft Function and Survival in Lewis–Brown Norway Rat Orthotopic Liver Transplantation Model

Biomolecules, 2022
Interleukin-18 (IL-18) can effectively activate natural killer (NK) cells and induce large concentrations of interferon-γ (IFN-γ). In healthy humans, IL-18 binding protein (IL-18BP) can inhibit the binding of IL-18 to IL-18R and counteract the biological
Qiang Meng, Weikang Wu, Wenjie Zhang, Juzheng Yuan, Long Yang, Xuan Zhang, Kaishan Tao   +6 more
doaj   +1 more source

Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity [PDF]

PeerJ, 2022
Background Interleukin-18 (IL-18) is prone to form multimers resulting in inactive aggregates, making this cytokine unstable for clinical use. Therefore, mutations have been introduced into recombinant IL-18 to overcome this issue. Methods To prevent the
Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Supayang Piyawan Voravuthikunchai, Natnaree Sangkaew, Napat Prompat, Teerapol Srichana, Varomyalin Tipmanee   +7 more
doaj   +2 more sources

High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura

Haematologica, 2009
To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-γ, IL-4 plasma levels and platelet counts ...
Ning-ning Shan, Xiao-juan Zhu, Qian Wang, Chun-yan Wang, Ping Qin, Jun Peng, Ming Hou   +6 more
doaj   +1 more source

IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii

Cell Reports, 2023
Summary: Interleukin-18 (IL-18) promotes natural killer (NK) and T cell production of interferon (IFN)-γ, a key factor in resistance to Toxoplasma gondii, but previous work has shown a limited role for endogenous IL-18 in control of this parasite ...
Joseph T. Clark, Orr-El Weizman, Daniel L. Aldridge, Lindsey A. Shallberg, Julia Eberhard, Zachary Lanzar, Devon Wasche, John D. Huck, Ting Zhou, Aaron M. Ring, Christopher A. Hunter   +10 more
doaj   +1 more source

Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]

, 2009
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M., Pickett, J. A., Dufour, S. G. L., Zhou, J.J., Keep, N. H., Dufour, Samuel, Field, Linda M., He, X., Hooper, A.M., Hooper, A. M., Pickett, John A., Pickett, J.A., He, Xiaoli, Dufour, S., Field, L. M., Keep, Nicholas H., Robertson, G., Robertson, Giles, Zhou, J-J., Hooper, Antony M., Zhou, Jing-Jiang, Hooper, Tony, Pickett, John, Field, Lin   +23 more
core   +1 more source

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]

, 2004
Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas, Goff, JP, Goff, Jesse P, Lippolis, JD, John D. Lippolis, Paape, Max, Bannerman, Douglas D, Paape, Max J, Kimura, K, Jayne C. Hope, Hope, Jayne C, Kimura, Kayoko, Lippolis, John D, Douglas D. Bannerman, Max J. Paape, Lippolis, John, Hope, Jayne, Kayoko Kimura, Hope, Jayne; id_orcid, Jesse P. Goff, Goff, Jesse   +20 more
core   +1 more source

IL–18 and IL–18 binding protein levels in patients with dengue virus infection

Asian Pacific Journal of Tropical Medicine, 2010
AbstractObjectiveTo determine the levels of IL-18 and IL-18 binding protein (BP) in patients with dengue virus infection.MethodsAcute and convalescent sera were collected from each patient. Control group was sera from blood donors. The levels of both IL-18 and IL-18BP were measured by ELISA assays.ResultsIt was shown that IL-18 and IL-18BP levels were ...
Chirathaworn, Chintana, Poovorawan, Yong, Vuthitanachot, Viboonsak   +2 more
openaire   +1 more source

Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales [PDF]

, 2011
Single-stranded DNA binding proteins (SSBs) based on the OB-fold are considered ubiquitous in nature and play a central role in many DNA transactions including replication, recombination and repair.
Kroonin, Eugene V., Naismith, Jim, McMahon, Stephen, White, Malcolm F, Sonia Paytubi, Catherine H. Botting, Graham, Shirley, Botting, Catherine Helen, James H. Naismith, Malcolm F. White, Paytubi, Sonia, Shirley Graham, Liu, Huanting, Kira S. Makarova, Makarova, Kira S., Stephen A. McMahon, Huanting Liu, Eugene V. Koonin, Koonin, Eugene V., White, Malcolm F.; id_orcid, McMahon, Stephen A., Botting, Catherine H., Naismith, James H.   +22 more
core   +1 more source

Role of Interleukin-18 in vascular injury: a new pharmacological target for the prevention of restenosis [PDF]

, 2006
Background: Studies in humans as well as in animal models suggest that interleukin-18 (IL-18) plays a crucial role in vascular pathologies. IL-18 is a strong predictor of cardiovascular death in angina and is involved in atherotic plaque destabilization.
Grassia, Gianluca
core   +1 more source

Interleukin-18 in Inflammatory Kidney Disease

Frontiers in Medicine, 2021
Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response.
Yasuaki Hirooka, Yuji Nozaki
doaj   +1 more source