Interleukin-18 and IL-18BP in inflammatory dermatological diseases [PDF]
Frontiers in Immunology, 2023 Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xiaoyun Wang +8 more
doaj +4 more sources
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii [PDF]
Cell Reports, 2023 Summary: Interleukin-18 (IL-18) promotes natural killer (NK) and T cell production of interferon (IFN)-γ, a key factor in resistance to Toxoplasma gondii, but previous work has shown a limited role for endogenous IL-18 in control of this parasite ...
Joseph T. Clark +10 more
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Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells [PDF]
Mediators of Inflammation, 2017 IL-18 has been found to be associated with eczema. However, little is known of the role of IL-18 binding protein (BP) and IL-18 receptor (R) in eczema.
Yalin Hu +7 more
doaj +5 more sources
IL-18 and IL-18BP: A Unique Dyad in Health and Disease [PDF]
International Journal of Molecular SciencesInterleukin-18 (IL-18) serves a dual function in the immune system, acting as a “double-edged sword” cytokine. Depending on the microenvironment and timing, IL-18 can either drive harmful inflammation or restore immune homeostasis. Pathologies characterized by elevated IL-18, recently proposed to be termed IL-18opathies, highlight the therapeutic ...
Daniela Novick, Novick Daniela
exaly +4 more sources
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy [PDF]
Nature, 2020 Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2. In an effort to identify alternative cytokine pathways for immunotherapy, we found that components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating ...
Ting Zhou +2 more
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Inherited IL-18BP deficiency in human fulminant viral hepatitis [PDF]
Journal of Experimental Medicine, 2019 Fulminant viral hepatitis (FVH) is a devastating and unexplained condition that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. We report a child who died of FVH upon infection with hepatitis A virus (HAV) at age 11 yr and who was homozygous for a private 40-nucleotide deletion in IL18BP, which encodes ...
Bertrand Boisson +2 more
exaly +7 more sources
Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral hepatitisIL-18BP deficiency and fulminant viral hepatitis [PDF]
Journal of Human ImmunityA previous report described an inherited deficiency of IL-18BP, a soluble antagonist of IL-18, in an Algerian patient who died of fulminant viral hepatitis (FVH) A. We report here an Egyptian family with two siblings who died from FVH following infection
Dalia Abd Elaziz +10 more
doaj +4 more sources
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia [PDF]
Journal of Neuroinflammation, 2012 Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported ...
Palladino Ilaria +7 more
doaj +7 more sources
Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome [PDF]
Mediators of Inflammation, 2014 Objective. More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis ...
Qingwei Ji +11 more
doaj +5 more sources
IL-18BP Improves Early Graft Function and Survival in Lewis–Brown Norway Rat Orthotopic Liver Transplantation Model [PDF]
Biomolecules, 2022 Interleukin-18 (IL-18) can effectively activate natural killer (NK) cells and induce large concentrations of interferon-γ (IFN-γ). In healthy humans, IL-18 binding protein (IL-18BP) can inhibit the binding of IL-18 to IL-18R and counteract the biological
Qiang Meng +6 more
doaj +2 more sources