Interleukin-18 and IL-18BP in inflammatory dermatological diseases [PDF]
Frontiers in Immunology, 2023 Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xian Jiang, Lian Wang, Gu He
exaly +6 more sources
Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral hepatitis [PDF]
J Hum ImmunA previous report described an inherited deficiency of IL-18BP, a soluble antagonist of IL-18, in an Algerian patient who died of fulminant viral hepatitis (FVH) A. We report here an Egyptian family with two siblings who died from FVH following infection
Aysima Atilgan Lülecioğlu +2 more
exaly +6 more sources
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii. [PDF]
Cell Rep, 2023 Summary: Interleukin-18 (IL-18) promotes natural killer (NK) and T cell production of interferon (IFN)-γ, a key factor in resistance to Toxoplasma gondii, but previous work has shown a limited role for endogenous IL-18 in control of this parasite ...
Clark JT +10 more
europepmc +4 more sources
Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells. [PDF]
Mediators Inflamm, 2017 IL-18 has been found to be associated with eczema. However, little is known of the role of IL-18 binding protein (BP) and IL-18 receptor (R) in eczema.
Hu Y +7 more
europepmc +5 more sources
Clinical Oncology and Cancer Research, 2009 OBJECTIVE To study the relationship between the serum levels of IL-18 and IL-18BP in the development and growth of primary liver cancer, benign liver tumors and liver cirrhosis and to determine the value of serum IL-18 and IL-18BP in the diagnosis of
Xianghui LIAO +2 more
exaly +4 more sources
IL-18BP Improves Early Graft Function and Survival in Lewis-Brown Norway Rat Orthotopic Liver Transplantation Model. [PDF]
Biomolecules, 2022 Interleukin-18 (IL-18) can effectively activate natural killer (NK) cells and induce large concentrations of interferon-γ (IFN-γ). In healthy humans, IL-18 binding protein (IL-18BP) can inhibit the binding of IL-18 to IL-18R and counteract the biological
Meng Q +6 more
europepmc +2 more sources
[Mechanisms by which interleukin-18 binding protein regulates the NLRP3 inflammasome in Kawasaki disease-related coronary artery lesions]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiKawasaki disease (KD) is an acute febrile illness characterized by systemic vasculitis, with coronary artery lesion (CAL) representing its most serious complication.
Xu W, Wang S, Li TH.
europepmc +2 more sources
IL-18 Binding Protein, a biomarker of strength maintenance after surgery but reduced physical performance in age-related sarcopenia. [PDF]
PLoS OneInflammation is thought to contribute to muscle loss in acute and chronic sarcopenia. Which inflammatory proteins contribute to sarcopenia in any condition is not clear.
Paul R +7 more
europepmc +2 more sources
Elevated plasma IL-37, IL-18, and IL-18BP concentrations in patients with acute coronary syndrome. [PDF]
Mediators Inflamm, 2014 Objective. More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis ...
Ji Q +11 more
europepmc +2 more sources
IL-18 and MIG increase one year after transition to dolutegravir-based dual therapy despite sustained viral suppression. [PDF]
Front ImmunolIntroductionModern antiretroviral treatment allowed a significant improvement in the life expectancy of people with HIV (PWH), exhibiting robust and sustained efficacy with scarce toxicities, both in two-drug regimens (2DRs) and three-drug regimens (3DRs)
Pérez-González A +6 more
europepmc +2 more sources