Results 41 to 50 of about 1,777 (151)
Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP [PDF]
Journal of Leukocyte Biology, 2014 AbstractIL-18 is a proinflammatory and immune regulatory cytokine, member of the IL-1 family. IL-18 was initially identified as an IFN-γ-inducing factor in T and NK cells, involved in Th1 responses. IL-18 is produced as an inactive precursor (pro-IL-18) that is enzymatically processed into a mature form by Casp1.
Marina, Fabbi +2 more
openaire +2 more sources
Interleukin-18 and interleukin-18 Binding Protein
Frontiers in Immunology, 2013 Interleukin-18 (IL 18) is a member of the IL 1 family of cytokines. Increasing reports have expanded the role of IL 18 in mediating inflammation in animal models of disease using IL 18 deficient mice, neutralization of IL 18 or deficiency in the IL 18 ...
Charles eDinarello +6 more
doaj +1 more source
Frontiers in Immunology, 2012 Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition due to the association of an infectious agent with lymphocyte cytotoxicity defects, either of congenital genetic origin in children or presumably acquired in adults. In HLH patients,
Laura eChiossone +25 more
doaj +1 more source
Pathogens, 2020 A thorough understanding of the processes modulating the innate and acquired immune response to Mycobacterium tuberculosis (M.tb) infection in the context of gene expression is still a scientific and diagnostic problem.
Sebastian Wawrocki +4 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani +17 more
wiley +1 more source
Current Issues in Molecular Biology, 2022 Adenomyosis is a uterine pathology characterized by a deep invasion of endometrial glands and stroma, disrupting the endometrial–myometrial interface (EMI).
Liang-Hsuan Chen +4 more
doaj +1 more source
Arthritis &Rheumatology, Volume 78, Issue 9, Page 1961-1974, September 2026.Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller +16 more
wiley +1 more source
IL-1 family cytokines and soluble receptors in systemic lupus erythematosus
Arthritis Research & Therapy, 2018 Background Dysregulated production of cytokines has a critical role in systemic lupus. The aim of this work is to identify, by a comprehensive analysis of IL-1 family cytokines and receptors in serum, correlation between cytokines/receptors’ levels and ...
Paola Italiani +7 more
doaj +1 more source
Experimental Physiology, Volume 111, Issue 8, Page 3742-3752, 1 August 2026.Abstract Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy. The mitochondrial‐derived peptide mitochondrial open reading frame of the 12S rRNA type‐C (MOTS‐c) has emerged as a promising regulator of metabolic and inflammatory pathways.
Aimee R. Mills +3 more
wiley +1 more source
ACR Open Rheumatology, 2022 Objective Improved biomarkers of current disease activity and prediction of relapse are needed in antineutrophil cytoplasmic antibody–associated vasculitis (AAV).
Paul A. Monach +14 more
doaj +1 more source