Results 51 to 60 of about 1,777 (151)

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Efficacy of Fowlpox Virus Vector Vaccine Expressing VP2 and Chicken Interleukin-18 in the Protection against Infectious Bursal Disease Virus

Vaccines, 2023
In mammals, the role of interleukin-18 (IL-18) in the immune response is to drive inflammatory and, normally therefore, anti-viral responses. IL-18 also shows promise as a vaccine adjuvant in mammals. Chicken IL-18 (chIL-18) has been cloned.
Ibrahim Eldaghayes, Lisa Rothwell, Michael Skinner, Abdunaser Dayhum, Pete Kaiser   +4 more
doaj   +1 more source

Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome

Arthritis &Rheumatology, Volume 78, Issue 2, Page 463-474, February 2026.
Serum cytokine profiling was performed using Luminex (48 cytokines) and ELISA (5 cytokines). Assessment of key cytokines (IFN‐α, IL‐18, IL‐6, CXCL9) delineated five dominant inflammatory patterns: I, IFN‐α–dominant CSS; II, IL‐18–dominant CSS; III, IL‐6–dominant CSS; IV, IFN‐γ–dominant CSS; and V, IL‐6 & IFN‐γ intermediate CSS.
Shuya Kaneko, Maho Hatano, Asami Shimbo, Futaba Miyaoka, Hitoshi Irabu, Yuko Akutsu, Yuko Hayashi, Mao Mizuta, Yasuo Nakagishi, Keiji Akamine, Naomi Iwata, Kenji Furuno, Takayuki Tanaka, Kazuyuki Ueno, Shuhei Fujita, Koji Yokoyama, Toshinori Minato, Kazushi Izawa, Takahiro Yasumi, Tadashi Matsubayashi, Tadashi Hosoya, Hiroki Nishikawa, Junya Fujimura, Ryoko Asano, Yuko Sugita, Kenichi Watanabe, Anna Kobayashi, Takuya Endo, Katsuhide Eguchi, Ryuta Nishikomori, Ryuhei Yasuoka, Takaki Asano, Miyako Kanno, Kazuya Hamada, Yuji Fujita, Daisuke Hayashi, Shojiro Watanabe, Takeshi Shiba, Shinsuke Yasuda, Masaaki Mori, Hirokazu Kanegane, Masatoshi Takagi, Masaki Shimizu   +42 more
wiley   +1 more source

Interleukins in Major Depressive Disorder: Lessons From Autoimmune Diseases and Pathways to Clinical Translation

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Major Depressive Disorder (MDD) is a leading cause of disability, and limitations of the monoamine hypothesis have spurred interest in an inflammatory model of depression. Immune dysregulation, especially involving interleukins (ILs), contributes to depression.
Adnan Akif, Mohammad Fahim Kadir, Md. Rabiul Islam   +2 more
wiley   +1 more source

Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome

Blood, 2005
Hemophagocytic syndrome (HPS) is characterized by an uncontrolled and poorly understood activation of T-helper 1 (Th-1) lymphocytes and macrophages. We studied 20 patients with HPS secondary to infections, autoimmune disease, lymphoma, or cancer and observed that the concentrations of serum interleukin 18 (IL-18), a strong inducer of Th-1 responses ...
Karin, Mazodier, Valérie, Marin, Daniela, Novick, Catherine, Farnarier, Stéphane, Robitail, Nicolas, Schleinitz, Véronique, Veit, Pascale, Paul, Menachem, Rubinstein, Charles A, Dinarello, Jean-Robert, Harlé, Gilles, Kaplanski   +11 more
openaire   +3 more sources

Interleukin‐17, Interleukin‐18, T Regulatory Cells, and T‐Helper 17 (Th17) Cells Play a Role in Heart Failure: A Systematic Review and Meta‐Analysis

Cardiology Research and Practice, Volume 2026, Issue 1, 2026.
Background The objective of this study was to assess whether interleukin‐17 or 18 (IL‐17 or IL‐18), regulatory T cells (Tregs), and T helper17 (Th17) serum concentrations were different in chronic heart failure not associated with myocarditis compared to healthy individuals. Methods We searched MEDLINE and Embase for studies with data on IL‐17 or IL‐18
Sohat Sharma, Jayant Seth, Cameron J. Leong, Simon W. Rabkin, Irfan Ahmad   +4 more
wiley   +1 more source

A Comprehensive Review of AIM2 in Cancer: Functional Roles, Molecular Pathways, and Clinical Relevance

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Inflammation has been recognized as a component of cancer progression, and inflammasome receptor components also regulate various biological processes, including cell proliferation, gene transcription, and tumorigenesis. Accumulating evidence indicates that the AIM2 inflammasome influences tumor progression via multiple concurrent mechanisms, one of ...
Nuo Wang, Shaoxian Wu, Zhang Fang, Lujun Chen, Xiao Zheng, Poorani Gurumallesh   +5 more
wiley   +1 more source

Upregulation of circulating microRNA-134 in adult-onset Still’s disease and its use as potential biomarker

Scientific Reports, 2017
Adult-onset Still’s disease (AOSD) is a multi-systemic inflammatory disorder of unknown etiology. To date, no single diagnostic test is available for AOSD. Herein, we investigated the pathogenic role of microRNAs in AOSD. MicroRNA profiles in plasma from
Tsai-Ling Liao, Yi-Ming Chen, Chia-Wei Hsieh, Hsin-Hua Chen, Hsiu-Chin Lee, Wei-Ting Hung, Kuo-Tung Tang, Der-Yuan Chen   +7 more
doaj   +1 more source

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao, Yixun Wang, Zhaohui Zhang, Xingguang Qu, Gaosheng Zhou, Laurent L′homme   +5 more
wiley   +1 more source

IL-18/IL-37/IP-10 signalling complex as a potential biomarker for discriminating active and latent TB.

PLoS ONE, 2019
BACKGROUND:Currently, there are serious limitations in the direct diagnosis of active tuberculosis (ATB). We evaluated the levels of the IL-18/IL-37/IP-10 signalling complex proteins in Mycobacterium tuberculosis (M.tb)-specific antigen-stimulated ...
Sebastian Wawrocki, Michal Seweryn, Grzegorz Kielnierowski, Wieslawa Rudnicka, Marcin Wlodarczyk, Magdalena Druszczynska   +5 more
doaj   +1 more source