Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases. [PDF]
Biomedicines, 2022 Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Park SY +4 more
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The role of Interleukin-18 and interleukin-18 binding protein in K/BxN serum transfer- induced arthritis [PDF]
Front Immunol, 2023 BackgroundInterleukin-18 is a proinflammatory cytokine, the activity of which is regulated by its natural inhibitor, IL-18 binding protein (IL-18BP). Elevated circulating levels of IL-18 have been observed in patients with systemic juvenile idiopathic ...
Fauteux-Daniel S +5 more
europepmc +5 more sources
A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. [PDF]
PLoS Pathog, 2012 Interleukin 18 (IL18) is a cytokine that plays an important role in inflammation as well as host defense against microbes. Mammals encode a soluble inhibitor of IL18 termed IL18 binding protein (IL18BP) that modulates IL18 activity through a negative ...
Krumm B +4 more
europepmc +4 more sources
Interleukin-18 binding protein deficiency results in gut microbiota dysbiosis and aggravated diet-induced MASH in mice. [PDF]
JHEP RepBackground & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) are now the most prevalent hepatic disorders worldwide.
Somm E +16 more
europepmc +2 more sources
Acquisition of different transcriptional shear mRNA and biological function of porcine interleukin 18 binding protein in PRRSV infection. [PDF]
mBioInterleukin-18 binding protein (IL-18BP), a natural regulator molecule of the pro-inflammatory cytokine interleukin-18 (IL-18), plays an important role in regulating the expression of the cellular immunity factor interferon-γ (IFN-γ).
Zhao H-z +5 more
europepmc +2 more sources
[Mechanisms by which interleukin-18 binding protein regulates the NLRP3 inflammasome in Kawasaki disease-related coronary artery lesions]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiKawasaki disease (KD) is an acute febrile illness characterized by systemic vasculitis, with coronary artery lesion (CAL) representing its most serious complication.
Xu W, Wang S, Li TH.
europepmc +2 more sources
IL18BP in cancer: a double-edged sword and emerging therapeutic opportunity. [PDF]
Front ImmunolInterleukin-18-binding protein (IL18BP) is a pivotal extracellular gatekeeper of IL-18 activity and an emerging therapeutic target in cancer.
Huang C, Jiang Y, Wang N, Du B, Huang Q.
europepmc +2 more sources
Mimic antibodies: leveraging ligand mimicry for epitope-targeted antibody discovery. [PDF]
MAbsAntibodies are renowned for their ability to bind diverse targets with high affinity and specificity, yet identifying binders with predefined epitope specificity remains a major challenge.
Abanades B +14 more
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Computational and Structural Biotechnology Journal, 2023 Interleukin 18 (IL18) is a pro-inflammatory cytokine that modulates innate and adaptive immune responses. IL18 activity is tightly controlled by the constitutively secreted IL18 binding protein (IL18BP).
Yılmaz Yücehan Yazıcı +2 more
doaj +1 more source
IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.
PLoS ONE, 2021 Idiopathic pulmonary fibrosis is a chronic, fibrosing interstitial pneumonia that presents with various clinical courses and progression ranging from rapid to slow.
Yu Nakanishi +11 more
doaj +1 more source